Results 111 to 120 of about 6,006,073 (362)

Drug Discovery in the Clouds

Chemistry & Biology, 2012
Data security and privacy are central to the success of these cloud-based tools. “One can easily make your microscope or telescope as small or as large as you want to in terms of permissions to maintain security and maximally mine the data,” says CDD's Bunin.
openaire   +2 more sources

Tracking Health Related Quality of Life From Diagnosis to Follow‐Up Among Australian Children With Acute Lymphoblastic Leukaemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Acute lymphoblastic leukaemia (ALL) is one of the most treatable forms of paediatric cancer; however, there is a substantial burden of treatment‐related toxicities (TRTs). In addition, the long‐term changes in children's health‐related quality of life (HRQoL) due to toxic treatments are not well understood.
Clare Ghows, Clarissa E. Schilstra, Karen McCleary, Nancy E. Briggs, Rishi S. Kotecha, Richard De Abreu Lourenco, Shanti Ramachandran, Ruelleyn Cockcroft, Rachel Conyers, Siobhan Cross, Luciano Dalla‐Pozza, Peter Downie, Tamas Revesz, Michael Osborn, Frank Alvaro, Claire E. Wakefield, Glenn M. Marshall, Toby Trahair, Marion K. Mateos, Joanna E. Fardell   +19 more
wiley   +1 more source

Solid Pseudopapillary Neoplasm of the Pancreas in Children and Adolescents: Expert Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Solid pseudopapillary neoplasm of the pancreas (SPN) is a rare low‐grade malignant exocrine pancreatic tumor, mostly discovered during the second decade of life in females, with a very good prognosis, provided microscopically complete surgical excision is achieved.
Sabine Irtan, Michael Abele, Calogero Virgone, Michaela Kuhlen, Ricardo Lopez‐Almarez, Tal Ben‐Ami, Ewa Bien, Maja Cesen, Malgorzata A. Krawczyk, Andrea Ferrari, Gianni Bisogno, Yves Reguerre, Dominik T. Schneider, Louise Galmiche, Jorg Fuchs, Sarah Braungart, Bilgehan Yalcin, Ines B. Brecht, Daniel Orbach   +18 more
wiley   +1 more source

Blocking the Hemagglutinin of Influenza A Virus by Multivalent Inhibitors [PDF]

, 2019
The aim of this thesis is to develop multivalent carbohydrate-based ligands as inhibitors of the adhesion of the Influenza A virus (IAV). The adhesion protein hemagglutinin (HA) plays a central role in the infection process, and has potential as a drug ...
Afd Chemical Biology and Drug Discovery, Chemical Biology and Drug Discovery, Lu, Wenjing   +2 more
core  

A renaissance of neural networks in drug discovery [PDF]

, 2020
© 2016 Informa UK Limited, trading as Taylor & Francis Group.Introduction: Neural networks are becoming a very popular method for solving machine learning and artificial intelligence problems.
Winkler D., Baskin I., Tetko I.
core  

QSPRpred: a Flexible Open-Source Quantitative Structure-Property Relationship Modelling Tool

Journal of Cheminformatics
Building reliable and robust quantitative structure–property relationship (QSPR) models is a challenging task. First, the experimental data needs to be obtained, analyzed and curated.
Helle W. van den Maagdenberg, Martin Šícho, David Alencar Araripe, Sohvi Luukkonen, Linde Schoenmaker, Michiel Jespers, Olivier J. M. Béquignon, Marina Gorostiola González, Remco L. van den Broek, Andrius Bernatavicius, J. G. Coen van Hasselt, Piet. H. van der Graaf, Gerard J. P. van Westen   +12 more
doaj   +1 more source

EB1010, a putative Christensenellaceae-derived microbial peptide, exhibits anti-inflammatory activity and therapeutic potential in ulcerative colitis

Gut Microbes
The gut microbiota plays a pivotal role in modulating the immune system, fostering immune tolerance, and defending against pathogens. Among its bioactive products, microbiota-derived peptides hold therapeutic promise for inflammatory diseases.
Maria L. Orsini Delgado, Camille Baudesson de Chanville, Hélène Pfister, Laureen Bardouillet, William Farin, Philippe Rinaudo, Jessica Quessel, Francesco Strozzi, Hélène Pereira, Marc Maresca, Cendrine Nicoletti, Eric Di Pasquale, Camille Mailhac, Valentine Thomas, Stephanie Blum, Gregoire Chevalier, Hélène Toussaint, Souphalone Luangsay, Christophe Bonny, Laurent Chene, Antonietta Cultrone   +20 more
doaj   +1 more source

Structure and dynamics in drug discovery

npj Drug Discovery
The roles of computing in structure-based drug discovery are considered, from early studies based on some of the first experimental structures of enzyme-inhibitor complexes, through the use of advanced molecular dynamics simulations and machine learning ...
Haixin Wei, J. A. McCammon
semanticscholar   +1 more source

Ovarian Sex Cord Stromal Tumors in Children and Adolescents—The European Standard Clinical Practice Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT As part of the European Cooperative Study Group for Paediatric Rare Tumours initiative, we developed standard clinical practice guidelines for ovarian sex cord stromal tumors, based on comprehensive national and international cohort analyses, literature review, and a final expert consensus conference.
Dominik T. Schneider, Kris‐Ann Schultz, Nora Schnitzler, Michael Abele, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Ines B. Brecht, Maja Cesen, Andrea Ferrari, Michaela Kuhlen, Malgorzata A. Krawczyk, Ricardo Lopez‐Almaraz, Yves Reguerre, Calogero Virgone, Daniel Orbach   +15 more
wiley   +1 more source

Trends in GPCR drug discovery: new agents, targets and indications [PDF]

, 2017
G protein-coupled receptors (GPCRs) are the most intensively studied drug targets, mostly due to their substantial involvement in human pathophysiology and their pharmacological tractability.
Gloriam, David E, Helgi B. Schiöth, Hauser, Alexander Sebastian, Misty M. Attwood, Hauser, Alexander S, Rask-Andersen, Mathias,, David E. Gloriam, Alexander S. Hauser, Schiöth, Helgi B., Rask-Andersen, Mathias, Schiöth, Helgi B.,, Gloriam, David E., Mathias Rask-Andersen, Attwood, Misty M.,, Attwood, Misty M.   +14 more
core   +1 more source