Results 91 to 100 of about 6,006,073 (362)

Association Between Dinutuximab Beta Exposure and Post‐End‐of‐Treatment Survival in Neuroblastoma: A Weighted Patient‐Level Analysis of Three Clinical Studies

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objectives The association between exposure to dinutuximab beta (DB) and event‐free survival (EFS) or overall survival (OS) of neuroblastoma patients was assessed using data collected during three clinical trials (five cohorts). Methods A systematic review (March 2026) was conducted to identify relevant studies (prospective; registered DB ...
Przemysław Holko, Holger N. Lode, Alberto Garaventa, Carla Manzitti, Roberto Luksch, Dominique Valteau‐Couanet, Marion Gambart, John Anderson, Juliet Gray, Adela Canete, Lucas Moreno, Aleksandra Wieczorek, Cormac Owens, Shifra Ash, Isaac Yaniv, Genevieve Laureys, Hans Loibner, Katarzyna Śladowska, Ruth Ladenstein, Paweł Kawalec   +19 more
wiley   +1 more source

Discovery of a new drug-like series of OGT inhibitors by virtual screening [PDF]

, 2022
O-GlcNAcylation is an essential post-translational modification installed by the enzyme O-β-N-acetyl-d-glucosaminyl transferase (OGT). Modulating this enzyme would be extremely valuable to better understand its role in the development of serious human ...
Anderluh, Marko, Afd Chemical Biology and Drug Discovery, Elena M. Loi, Matjaž Weiss, David J. Vocadlo, Balsollier, Cyril, Matthew G. Alteen, Chemical Biology and Drug Discovery, Loi, Elena Maria, van Eekelen, Kevin, Kevin van Eekelen, Tihomir Tomašič, Loi, Elena M, Gobec, Martina, Martina Gobec, Tomašič, Tihomir, Roland J. Pieters, Alteen, Matthew G, Weiss, Matjaž, Loi, Elena M., Cyril Balsollier, Marko Anderluh, Vocadlo, David J, Pieters, Roland J., Vocadlo, David J., Alteen, Matthew G., Pieters, Roland J   +26 more
core   +1 more source

Herbo-Mineral Medicine, Cardiogrit Gold, Exhibits Protective Effects in Caenorhabditis elegans Model of Doxorubicin-Induced Cardiotoxicity

Journal of Toxicology
Doxorubicin, an effective antineoplastic agent, is often prescribed for the treatment of various carcinomas. However, the use of doxorubicin becomes limited due to its adverse effects like cardiotoxicity, dysmenorrhea, and leucopenia. Cardiogrit Gold (CG)
Acharya Balkrishna, Saurabh Bhatti, Meenu Tomer, Sudeep Verma, Rishabh Dev, Anurag Varshney   +5 more
doaj   +1 more source

Deep generative molecular design reshapes drug discovery

Cell Reports Medicine, 2022
Summary Recent advances and accomplishments of artificial intelligence (AI) and deep generative models have established their usefulness in medicinal applications, especially in drug discovery and development.
Xiangxiang Zeng, Fei Wang, Yuan-Zhi Luo, Seung-gu Kang, Jian Tang, F. Lightstone, E. Fang, W. Cornell, R. Nussinov, F. Cheng   +9 more
semanticscholar   +1 more source

BMT4me En Español: Multisite Feasibility and Usability Testing of a Spanish‐Language mHealth Adherence Support App for Spanish‐Speaking Caregivers of Children After Hematopoietic Stem Cell Transplantation and Cancer Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Medication nonadherence during the first 100 days after pediatric hematopoietic stem cell transplantation (HSCT) and during oncology treatment increases risk for complications. BMT4me is a caregiver‐facing mobile health (mHealth) application providing medication reminders, symptom tracking, and note‐taking features to support ...
Micah A. Skeens, Madeline R. Peek, Bianca Franklin, Emre Sezgin, Melissa Beauchemin   +4 more
wiley   +1 more source

Artificial intelligence for small molecule anticancer drug discovery [PDF]

Introduction: The transition from conventional cytotoxic chemotherapy to targeted cancer therapy with small-molecule anticancer drugs has enhanced treatment outcomes. This approach, which now dominates cancer treatment, has several advantages.
Liu, Yu, Duo, Lihui, Tang, Bencan, Ren, Jianfeng, Hirst, Jonathan D.   +4 more
core   +2 more sources

Fragment-Based Drug Discovery: a Practical Approach [PDF]

, 2009
This book presents a company-based view of the recent progresses in fragment-based drug discovery (FBDD). The book is highly focussed on methodologies.
Giulio Rastelli, RASTELLI, Giulio
core   +1 more source

Nonclinical Safety Evaluation of Nonmutagenic Immunogrit Following Subacute 28-Day Repeated Dose Oral Toxicity in Sprague–Dawley Rats With GLP Compliance

Journal of Toxicology
Immunogrit is a traditional Ayurvedic medicine prescribed to patients for their general well-being. In this study, Immunogrit was evaluated for its subacute (28 days) repeated oral dose toxicity in male and female Sprague-Dawley (SD) rats of similar age ...
Acharya Balkrishna, Kunal Bhattacharya, Sudeep Verma, Himanshu Jangid, Savita Lochab, Anurag Varshney   +5 more
doaj   +1 more source

Unlocking the potential of generative AI in drug discovery.

Drug Discovery Today
Artificial intelligence (AI) is revolutionizing drug discovery by enhancing precision, reducing timelines and costs, and enabling AI-driven computer-aided drug design.
Amit Gangwal, Antonio Lavecchia
semanticscholar   +1 more source

DrugBank: a comprehensive resource for in silico drug discovery and exploration

Nucleic Acids Res., 2005
DrugBank is a unique bioinformatics/cheminformatics resource that combines detailed drug (i.e. chemical) data with comprehensive drug target (i.e. protein) information.
D. Wishart, Craig Knox, Anchi Guo, S. Shrivastava, Murtaza Hassanali, P. Stothard, Zhan Chang, Jennifer Woolsey   +7 more
semanticscholar   +1 more source