Results 71 to 80 of about 6,006,073 (362)

Discovery and binding mode of small molecule inhibitors of the apo form of human TDO2

Scientific Reports
Tryptophan-2,3-dioxygenase (TDO2) and indoleamine-2,3-dioxygenase (IDO1) are structurally distinct heme enzymes that catalyze the conversion of L-tryptophan to N-formyl-kynurenine, and play important roles in metabolism, inflammation, and tumor immune ...
Carina Lotz-Jenne, Roland Lange, Sylvaine Cren, Geoffroy Bourquin, Laksmei Goglia, Thierry Kimmerlin, Micha Wicki, Manon Müller, Nadia Artico, Sabine Ackerknecht, Philippe Pfaff, Christoph Joesch, Aengus Mac Sweeney   +12 more
doaj   +1 more source

Biological characterization of chemically diverse compounds targeting the Plasmodium falciparum coenzyme A synthesis pathway

Parasites & Vectors, 2016
Background In the fight against malaria, the discovery of chemical compounds with a novel mode of action and/or chemistry distinct from currently used drugs is vital to counteract the parasite’s known ability to develop drug resistance. Another desirable
Sabine Fletcher, Leonardo Lucantoni, Melissa L. Sykes, Amy J. Jones, John P. Holleran, Kevin J. Saliba, Vicky M. Avery   +6 more
doaj   +1 more source

Inhibition of triple negative breast cancer-associated inflammation, tumor growth and brain colonization by targeting monoacylglycerol lipase

Scientific Reports, 2022
While the prevalence of breast cancer metastasis in the brain is significantly higher in triple negative breast cancers (TNBCs), there is a lack of novel and/or improved therapies for these patients. Monoacylglycerol lipase (MAGL) is a hydrolase involved
Othman Benchama, Sergiy Tyukhtenko, Michael S. Malamas, Mark K. Williams, Alexandros Makriyannis, Hava Karsenty Avraham   +5 more
doaj   +1 more source

A novel anti-NGF PEGylated Fab’ provides analgesia with lower risk of adverse effects

mAbs, 2023
Nerve growth factor (NGF) has emerged as a key driver of pain perception in several chronic pain conditions, including osteoarthritis (OA), and plays an important role in the generation and survival of neurons.
Yukari Koya, Hirotsugu Tanaka, Eiji Yoshimi, Nobuaki Takeshita, Shuji Morita, Hiroki Morio, Kanako Mori, Hiroshi Fushiki, Masazumi Kamohara   +8 more
doaj   +1 more source

Artificial Intelligence (AI) Applications in Drug Discovery and Drug Delivery: Revolutionizing Personalized Medicine

Pharmaceutics
Artificial intelligence (AI) encompasses a broad spectrum of techniques that have been utilized by pharmaceutical companies for decades, including machine learning, deep learning, and other advanced computational methods.
D. Serrano, F. C. Luciano, Brayan J. Anaya, Baris Ongoren, A. Kara, Gracia Molina, Bianca I Ramirez, Sergio A Sánchez-Guirales, Jesus A Simon, Greta Tomietto, Chrysi Rapti, Helga K. Ruiz, Satyavati Rawat, Dinesh Kumar, A. Lalatsa   +14 more
semanticscholar   +1 more source

Therapeutic target database update 2022: facilitating drug discovery with enriched comparative data of targeted agents

Nucleic Acids Res., 2021
Drug discovery relies on the knowledge of not only drugs and targets, but also the comparative agents and targets. These include poor binders and non-binders for developing discovery tools, prodrugs for improved therapeutics, co-targets of therapeutic ...
Ying Zhou, Yintao Zhang, Xichen Lian, Fengcheng Li, Chaoxin Wang, Feng Zhu, Yunqing Qiu, Yuzong Chen   +7 more
semanticscholar   +1 more source

Personalized Zebrafish Models for Fusion‐Positive Pediatric Sarcomas

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Clinical sequencing efforts have revolutionized our approaches to categorizing pediatric cancers in real time. This has dramatically improved our ability to profile pediatric tumors, identify actionable vulnerabilities, and influence clinical care.
Lisa H. Hall, Emma N. Harrison, Genevieve C. Kendall   +2 more
wiley   +1 more source

Integrating Artificial Intelligence for Drug Discovery in the Context of Revolutionizing Drug Delivery

Life
Drug development is expensive, time-consuming, and has a high failure rate. In recent years, artificial intelligence (AI) has emerged as a transformative tool in drug discovery, offering innovative solutions to complex challenges in the pharmaceutical ...
A. Vișan, I. Neguț
semanticscholar   +1 more source

AlphaFold, allosteric, and orthosteric drug discovery: Ways forward

Drug Discovery Today, 2023
Drug discovery is arguably a highly challenging and significant interdisciplinary aim. The stunning success of the artificial intelligence-powered AlphaFold, whose latest version is buttressed by an innovative machine-learning approach that integrates ...
R. Nussinov, Mingzhen Zhang, Yonglan Liu, Hyunbum Jang   +3 more
semanticscholar   +1 more source

Ironic Medications: A Narrative‐Based Psycho‐Educational Intervention to Explore Patient–Provider Communication in Adolescents With Haematological Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Adolescents with haematological malignancies face significant emotional and relational challenges, often accompanied by difficulties in communicating their needs within the healthcare context. To address these issues, a narrative‐based psycho‐educational intervention based on the creation and prescription of Ironic Medications was ...
Marta Stoppa, Elena Pagani Bagliacca, Selena Russo, Giulia Rampoldi, Maria Grazia Strepparava, Adriana Cristina Balduzzi, Andrea Biondi, Marco Spinelli   +7 more
wiley   +1 more source