Results 71 to 80 of about 3,678,790 (312)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

In Silico drug repurposing pipeline using deep learning and structure based approaches in epilepsy

Scientific Reports
Due to considerable global prevalence and high recurrence rate, the pursuit of effective new medication for epilepsy treatment remains an urgent and significant challenge. Drug repurposing emerges as a cost-effective and efficient strategy to combat this
Xiaoying Lv, Jia Wang, Ying Yuan, Lurong Pan, Qi Liu, Jinjiang Guo   +5 more
doaj   +1 more source

Future challenges with DNA-encoded chemical libraries in the drug discovery domain

, 2019
Introduction: DNA-encoded chemical libraries (DELs) have come of age and emerged to become a powerful technology platform for ligand discovery in biomedical research and drug discovery.
Zhao, G, HUANG, Y, Li, Y, Li, X, Zhou, Y
core   +1 more source

Biophysics in drug discovery: impact, challenges and opportunities [PDF]

, 2016
Over the past 25 years, biophysical technologies such as X-ray crystallography, nuclear magnetic resonance spectroscopy, surface plasmon resonance spectroscopy and isothermal titration calorimetry have become key components of drug discovery platforms in
Danielson, U. Helena,, Danielson, U Helena, Chung, Chun-wa,, Nar, Herbert,, Egner, Ursula, U. Helena Danielson, Ursula Egner, Hennig, Michael,, Roderick E. Hubbard, Chung, Chun-Wa, Herbert Nar, Hennig, Michael, Nar, Herbert, Chun-wa Chung, Hubbard, Roderick E.,, Hubbard, Roderick E, Egner, Ursula,, Renaud, Jean-Paul,, Jean-Paul Renaud, Michael Hennig, Renaud, Jean-Paul, Hubbard, Roderick E. (author), Danielson, U. Helena (author), Hubbard, Roderick E., Chung, Chun-wa (author), Danielson, U. Helena, Renaud, Jean-Paul (author), Egner, Ursula (author), Nar, Herbert (author), Hennig, Michael (author)   +29 more
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Leishmaniasis drug discovery: recent progress and challenges in assay development

, 2017
Leishmaniasis, caused by the trypanosomatid protozoan Leishmania, is endemic in 98 countries worldwide, with morbidity and mortality increasing daily. Despite available drugs, leishmaniasis faces the challenge of emerging resistance and toxicity concerns
Todd B. Shelper, Bilal Zulfiqar, Zulfigar, Bilal, Vicky M. Avery, Avery, Vicky M, Shelper, Todd B   +5 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Doxorubicin resistance in breast cancer cells is mediated by extracellular matrix proteins

BMC Cancer, 2018
Background Cancer cell resistance to therapeutics can result from acquired or de novo-mediated factors. Here, we have utilised advanced breast cancer cell culture models to elucidate de novo doxorubicin resistance mechanisms.
Carrie J. Lovitt, Todd B. Shelper, Vicky M. Avery   +2 more
doaj   +1 more source

Revolutionizing Drug Discovery: A Comprehensive Review of AI Applications

The drug discovery and development process is very lengthy, highly expensive, and extremely complex in nature. Considering the time and cost constraints associated with conventional drug discovery, new methods must be found to enhance the declining ...
Ankit Ganeshpurkar, Atmaram Pawar, Rushikesh Dhudum   +2 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source