Results 61 to 70 of about 3,490,892 (315)

Challenges with matrix metalloproteinase inhibition and future drug discovery avenues

, 2020
Matrix metalloproteinases have been in the scope of pharmaceutical drug discovery for decades as promising targets for drug development. Until present, no modulator of the enzyme class survived clinical trials, all failing for various reasons ...
Riedl, Rainer, Fischer, Thomas
core   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

QSPRpred: a Flexible Open-Source Quantitative Structure-Property Relationship Modelling Tool

Journal of Cheminformatics
Building reliable and robust quantitative structure–property relationship (QSPR) models is a challenging task. First, the experimental data needs to be obtained, analyzed and curated.
Helle W. van den Maagdenberg, Martin Šícho, David Alencar Araripe, Sohvi Luukkonen, Linde Schoenmaker, Michiel Jespers, Olivier J. M. Béquignon, Marina Gorostiola González, Remco L. van den Broek, Andrius Bernatavicius, J. G. Coen van Hasselt, Piet. H. van der Graaf, Gerard J. P. van Westen   +12 more
doaj   +1 more source

EB1010, a putative Christensenellaceae-derived microbial peptide, exhibits anti-inflammatory activity and therapeutic potential in ulcerative colitis

Gut Microbes
The gut microbiota plays a pivotal role in modulating the immune system, fostering immune tolerance, and defending against pathogens. Among its bioactive products, microbiota-derived peptides hold therapeutic promise for inflammatory diseases.
Maria L. Orsini Delgado, Camille Baudesson de Chanville, Hélène Pfister, Laureen Bardouillet, William Farin, Philippe Rinaudo, Jessica Quessel, Francesco Strozzi, Hélène Pereira, Marc Maresca, Cendrine Nicoletti, Eric Di Pasquale, Camille Mailhac, Valentine Thomas, Stephanie Blum, Gregoire Chevalier, Hélène Toussaint, Souphalone Luangsay, Christophe Bonny, Laurent Chene, Antonietta Cultrone   +20 more
doaj   +1 more source

Blocking the Hemagglutinin of Influenza A Virus by Multivalent Inhibitors [PDF]

, 2019
The aim of this thesis is to develop multivalent carbohydrate-based ligands as inhibitors of the adhesion of the Influenza A virus (IAV). The adhesion protein hemagglutinin (HA) plays a central role in the infection process, and has potential as a drug ...
Afd Chemical Biology and Drug Discovery, Chemical Biology and Drug Discovery, Lu, Wenjing   +2 more
core  

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

In Silico drug repurposing pipeline using deep learning and structure based approaches in epilepsy

Scientific Reports
Due to considerable global prevalence and high recurrence rate, the pursuit of effective new medication for epilepsy treatment remains an urgent and significant challenge. Drug repurposing emerges as a cost-effective and efficient strategy to combat this
Xiaoying Lv, Jia Wang, Ying Yuan, Lurong Pan, Qi Liu, Jinjiang Guo   +5 more
doaj   +1 more source

Doxorubicin resistance in breast cancer cells is mediated by extracellular matrix proteins

BMC Cancer, 2018
Background Cancer cell resistance to therapeutics can result from acquired or de novo-mediated factors. Here, we have utilised advanced breast cancer cell culture models to elucidate de novo doxorubicin resistance mechanisms.
Carrie J. Lovitt, Todd B. Shelper, Vicky M. Avery   +2 more
doaj   +1 more source

Podophyllotoxin derivatives: drug discovery and development

, 1996
The exploration and exploitation of podophyllin formulations provide an example of how a plant extract with established ethnomedical use, but also causing toxicity, can provide a basis for new drug discovery and development.
Bohlin, Lars,, Rosén, Börje, Lars Bohlin, Börje Rosen   +3 more
core   +1 more source