Results 61 to 70 of about 3,678,790 (312)

Dual-targeted bacterial outer membrane vesicles enhance glioblastoma immunotherapy by regulating tumor microenvironment and inducing IFN-γ-mediated ferroptosis

Journal of Nanobiotechnology
Glioblastoma (GBM) immunotherapy is limited by the blood-brain barrier (BBB) and the tumor immune resistance. Here, we develop an engineered bacterial outer membrane vesicle (OMV) through safe and straightforward genetic modification of Escherichia coli,
Chen Chen, Xiaojing Zhu, Zefeng Song, Yutong Xing, Wenrui Jin, Fan Li, Pir Tariq Shah, Siqi Song, Haoran Geng, Kai Xu, Hong Wang, Zhenyong Wu   +11 more
doaj   +1 more source

Podophyllotoxin derivatives: drug discovery and development

, 1996
The exploration and exploitation of podophyllin formulations provide an example of how a plant extract with established ethnomedical use, but also causing toxicity, can provide a basis for new drug discovery and development.
Bohlin, Lars,, Rosén, Börje, Lars Bohlin, Börje Rosen   +3 more
core   +1 more source

Assay development in leishmaniasis drug discovery: a comprehensive review

, 2021
Introduction: Cutaneous, muco-cutaneous and visceral leishmaniasis occur due to an infection with the protozoan parasite Leishmania. The current therapeutic options are limited mainly due to extensive toxicity, emerging resistance and variation in ...
Zulfiqar, Bilal, Avery, Vicky M, Bilal Zulfiqar, Vicky. M. Avery   +3 more
core   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Drug Discovery in the Clouds

Chemistry & Biology, 2012
Data security and privacy are central to the success of these cloud-based tools. “One can easily make your microscope or telescope as small or as large as you want to in terms of permissions to maintain security and maximally mine the data,” says CDD's Bunin.
openaire   +2 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

QSPRpred: a Flexible Open-Source Quantitative Structure-Property Relationship Modelling Tool

Journal of Cheminformatics
Building reliable and robust quantitative structure–property relationship (QSPR) models is a challenging task. First, the experimental data needs to be obtained, analyzed and curated.
Helle W. van den Maagdenberg, Martin Šícho, David Alencar Araripe, Sohvi Luukkonen, Linde Schoenmaker, Michiel Jespers, Olivier J. M. Béquignon, Marina Gorostiola González, Remco L. van den Broek, Andrius Bernatavicius, J. G. Coen van Hasselt, Piet. H. van der Graaf, Gerard J. P. van Westen   +12 more
doaj   +1 more source

EB1010, a putative Christensenellaceae-derived microbial peptide, exhibits anti-inflammatory activity and therapeutic potential in ulcerative colitis

Gut Microbes
The gut microbiota plays a pivotal role in modulating the immune system, fostering immune tolerance, and defending against pathogens. Among its bioactive products, microbiota-derived peptides hold therapeutic promise for inflammatory diseases.
Maria L. Orsini Delgado, Camille Baudesson de Chanville, Hélène Pfister, Laureen Bardouillet, William Farin, Philippe Rinaudo, Jessica Quessel, Francesco Strozzi, Hélène Pereira, Marc Maresca, Cendrine Nicoletti, Eric Di Pasquale, Camille Mailhac, Valentine Thomas, Stephanie Blum, Gregoire Chevalier, Hélène Toussaint, Souphalone Luangsay, Christophe Bonny, Laurent Chene, Antonietta Cultrone   +20 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Gaps between medical biology and AI drug discovery

Drug discovery is a complex, iterative process spanning biology, chemistry, pharmacology, and computational sciences. Artificial intelligence (AI) can accelerate this process but often misaligns with biological realities. Here, we highlight three crucial
Wang, Lipo, Yin, Yueming, Fu, Afu F.
core   +1 more source