Results 61 to 70 of about 1,396,646 (189)

Breaking the paradigm: Dr Insight empowers signature-free, enhanced drug repurposing [PDF]

, 2019
Motivation: Transcriptome-based computational drug repurposing has attracted considerable interest by bringing about faster and more cost-effective drug discovery.
Baldwin, Nicole E., Chan, Jinyan, Gu, Jinghua, Turner, Jacob A., Wang, Xuan   +4 more
core   +1 more source

In Silico drug repurposing pipeline using deep learning and structure based approaches in epilepsy

Scientific Reports
Due to considerable global prevalence and high recurrence rate, the pursuit of effective new medication for epilepsy treatment remains an urgent and significant challenge. Drug repurposing emerges as a cost-effective and efficient strategy to combat this
Xiaoying Lv, Jia Wang, Ying Yuan, Lurong Pan, Qi Liu, Jinjiang Guo   +5 more
doaj   +1 more source

Doxorubicin resistance in breast cancer cells is mediated by extracellular matrix proteins

BMC Cancer, 2018
Background Cancer cell resistance to therapeutics can result from acquired or de novo-mediated factors. Here, we have utilised advanced breast cancer cell culture models to elucidate de novo doxorubicin resistance mechanisms.
Carrie J. Lovitt, Todd B. Shelper, Vicky M. Avery   +2 more
doaj   +1 more source

Muropeptides and muropeptide transporters impact on host immune response

Gut Microbes
In bacteria, the cell envelope is the key element surrounding and protecting the bacterial content from mechanical or osmotic damages. It allows the selective interchanges of solutes, ions, cellular debris, and drugs between the cellular compartments and
Maria Lucia Orsini Delgado, Joao Gamelas Magalhaes, Rachel Morra, Antonietta Cultrone   +3 more
doaj   +1 more source

Why are olfactory ensheathing cell tumors so rare?

Cancer Cell International, 2019
The glial cells of the primary olfactory nervous system, olfactory ensheathing cells (OECs), are unusual in that they rarely form tumors. Only 11 cases, all of which were benign, have been reported to date.
Mariyam Murtaza, Anu Chacko, Ali Delbaz, Ronak Reshamwala, Andrew Rayfield, Brent McMonagle, James A. St John, Jenny A. K. Ekberg   +7 more
doaj   +1 more source

Significant impacts of metal ions from ancient oceans on nucleoside phosphorylation

BMC Chemistry
Nucleotides, such as 5’-AMP and ATP, are essential biomolecules in modern organisms. The phosphorylation of nucleosides to generate nucleotides occurs in complex prebiotic environments, where metal ions played a pivotal role, particularly in the metal ...
Qian Wu, Shuyi Lu, Chao Zhang, Wenda Zhong, Hua Zhao, Yufen Zhao, Biling Huang   +6 more
doaj   +1 more source

BCL6 enables Ph+ acute lymphoblastic leukaemia cells to survive BCR-ABL1 kinase inhibition. [PDF]

, 2011
Tyrosine kinase inhibitors (TKIs) are widely used to treat patients with leukaemia driven by BCR-ABL1 (ref. 1) and other oncogenic tyrosine kinases. Recent efforts have focused on developing more potent TKIs that also inhibit mutant tyrosine kinases ...
Braig, Melanie, Cerchietti, Leandro, Duy, Cihangir, Geng, Huimin, Graeber, Thomas G, Heisterkamp, Nora, Herzog, Sebastian, Hofmann, Wolf-Karsten, Hurtz, Christian, Jumaa, Hassan, Kim, Yong-mi, Klemm, Lars, Koeffler, H Phillip, Kweon, Soo-mi, Melnick, Ari, Müschen, Markus, Nahar, Rahul, Park, Eugene, Shojaee, Seyedmehdi, Swaminathan, Srividya, Wu, Hong, Ye, B Hilda, Yu, J Jessica   +22 more
core  

An LQT2-related mutation in the voltage-sensing domain is involved in switching the gating polarity of hERG

BMC Biology
Background Cyclic Nucleotide-Binding Domain (CNBD)-family channels display distinct voltage-sensing properties despite sharing sequence and structural similarity.
Zhipei Liu, Feng Wang, Hui Yuan, Fuyun Tian, Chuanyan Yang, Fei Hu, Yiyao Liu, Meiqin Tang, Meixuan Ping, Chunlan Kang, Ting Luo, Guimei Yang, Mei Hu, Zhaobing Gao, Ping Li   +14 more
doaj   +1 more source

Development of a Zebrafish Sepsis Model for High-Throughput Drug Discovery

Molecular Medicine, 2017
Sepsis is a leading cause of death worldwide. Current treatment modalities remain largely supportive. Intervention strategies focused on inhibiting specific mediators of the inflammatory host response have been largely unsuccessful, a consequence of an ...
Anju M. Philip, Youdong Wang, Antonio Mauro, Suzan El-Rass, John C. Marshall, Warren L. Lee, Arthur S. Slutsky, Claudia C. dos Santos, Xiao-Yan Wen   +8 more
doaj   +1 more source

Optimization of Protein-Protein Interaction Measurements for Drug Discovery Using AFM Force Spectroscopy [PDF]

, 2019
Increasingly targeted in drug discovery, protein-protein interactions challenge current high throughput screening technologies in the pharmaceutical industry.
Basson, Marc D., Chen, Liangliang, Dong, Lixin, Hou, Jing, Jiao, Nian-Dong, Liu, Lianqing, Monemianesfahani, Amir, Sun, Zhiyong, Xi, Ning, Yang, Ruiguo, Yang, Yongliang, Zeng, Bixi   +11 more
core   +1 more source