Results 41 to 50 of about 6,006,073 (362)
Generative artificial intelligence empowers digital twins in drug discovery and clinical trials
Expert Opinion on Drug Discovery, 2023 Introduction The concept of Digital Twins (DTs) translated to drug development and clinical trials describes virtual representations of systems of various complexities, ranging from individual cells to entire humans, and enables in silico simulations and
Maria Bordukova +4 more
semanticscholar +1 more source
Conversion of Aquaculture Waste into Biomedical Wealth: Chitin and Chitosan Journey
Advances in Materials Science and Engineering, 2022 Biowaste originating from aquaculture sector represents a potential feedstock to produce value-added substances and materials like chitin and chitosan. They are the long chain polymers of N-acetylglucosamine polymers with huge industrial and biomedical ...
Jerrine Joseph +8 more
doaj +1 more source
ChEMBL: a large-scale bioactivity database for drug discovery
Nucleic Acids Res., 2011 ChEMBL is an Open Data database containing binding, functional and ADMET information for a large number of drug-like bioactive compounds. These data are manually abstracted from the primary published literature on a regular basis, then further curated ...
A. Gaulton +10 more
semanticscholar +1 more source
Toxins and drug discovery [PDF]
Toxicon, 2014 Components from venoms have stimulated many drug discovery projects, with some notable successes. These are briefly reviewed, from captopril to ziconotide. However, there have been many more disappointments on the road from toxin discovery to approval of a new medicine. Drug discovery and development is an inherently risky business, and the main causes
openaire +4 more sources
Profitability and drug discovery
Industrial and Corporate Change, 2022 Abstract Pharmaceutical firms are highly profitable due to high markups enabled by high drug prices. This is justified by the argument that high profits provide incentives for innovation and help fund high research and development (R&D) costs.
Isik, Enes +2 more
openaire +1 more source
Challenges with matrix metalloproteinase inhibition and future drug discovery avenues [PDF]
, 2020 Matrix metalloproteinases have been in the scope of pharmaceutical drug discovery for decades as promising targets for drug development. Until present, no modulator of the enzyme class survived clinical trials, all failing for various reasons ...
Riedl, Rainer, Fischer, Thomas
core +1 more source
Screening a protein kinase inhibitor library against Plasmodium falciparum
Malaria Journal, 2017 Background Protein kinases have been shown to be key drug targets, especially in the area of oncology. It is of interest to explore the possibilities of protein kinases as a potential target class in Plasmodium spp., the causative agents of malaria ...
Irene Hallyburton +12 more
doaj +1 more source
Drug Repurposing: An Effective Tool in Modern Drug Discovery
Russian journal of bioorganic chemistry, 2023 Drug repurposing is using an existing drug for a new treatment that was not indicated before. It has received immense attention during the COVID-19 pandemic emergency.
V. Kulkarni +4 more
semanticscholar +1 more source
Accelerating antiviral drug discovery: lessons from COVID-19
Nature reviews. Drug discovery, 2023 During the coronavirus disease 2019 (COVID-19) pandemic, a wave of rapid and collaborative drug discovery efforts took place in academia and industry, culminating in several therapeutics being discovered, approved and deployed in a 2-year time frame ...
Annette von Delft +7 more
semanticscholar +1 more source