Results 41 to 50 of about 3,490,892 (315)

Herbomineral Medicine Peedanil Gold Exerts Analgesia in Neuropathy by Moderating Inflammatory Response and TRP Channel Expression in Sprague Dawley Rat Surgical Chronic Constriction Injury Model

Pain Research and Management
Conclusions: Altogether, the outcomes from the current study prove that PN-G is an effective antineuropathic agent with potential to manage pain as well as eliminate the underlying cause of neuroinflammation behind the chronicity of neuropathic pain.
Acharya Balkrishna, Shadrak Karumuri, Sandeep Sinha, Rani Singh, Rishabh Dev, Swati Haldar, Anurag Varshney   +6 more
doaj   +1 more source

Edible Pueraria lobata-Derived Exosomes Promote M2 Macrophage Polarization

Molecules, 2022
Pueraria lobata (known as Gegen) is an edible and medicinal herb that is a nutritious medicine food homology plant in China. Previous studies indicated that P. lobata plays an essential role in controlling cytokines.
Jiaqi Wu, Xiaoyu Ma, Yu Lu, Tao Zhang, Zuoqin Du, Jin Xu, Jingcan You, Ni Chen, Xin Deng, Jianbo Wu   +9 more
doaj   +1 more source

Functional pharmacology: the drug discovery bottleneck?

, 2004
It is our contention that functional pharmacology, particularly in vivo, must play a greater role in drug discovery if the promises of reductionist techniques are to be brought to full fruition.

core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Nonclinical Safety Evaluation of Renogrit: In Vitro Nonmutagenicity (OECD 471) and 28-Day Repeated Oral Dose Toxicity (OECD 407) in Sprague Dawley Rats

Journal of Toxicology
Renogrit is a prescription medicine developed by employing the traditional knowledge of Ayurveda for the management of kidney disorders. To support its extensive clinical investigations, Renogrit requires robust nonclinical safety assessments ...
Acharya Balkrishna, Aakanksha Tiwari, Himanshu Jangid, Kamaraj Mani, Savita Lochab, Sandeep Sinha, Anurag Varshney   +6 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Herbo-Mineral Medicine, Cardiogrit Gold, Exhibits Protective Effects in Caenorhabditis elegans Model of Doxorubicin-Induced Cardiotoxicity

Journal of Toxicology
Doxorubicin, an effective antineoplastic agent, is often prescribed for the treatment of various carcinomas. However, the use of doxorubicin becomes limited due to its adverse effects like cardiotoxicity, dysmenorrhea, and leucopenia. Cardiogrit Gold (CG)
Acharya Balkrishna, Saurabh Bhatti, Meenu Tomer, Sudeep Verma, Rishabh Dev, Anurag Varshney   +5 more
doaj   +1 more source

Drug discovery in advanced prostate cancer: translating biology into therapy [PDF]

, 2016
Castration-resistant prostate cancer (CRPC) is associated with a poor prognosis and poses considerable therapeutic challenges. Recent genetic and technological advances have provided insights into prostate cancer biology and have enabled the ...
Paul Workman, Johann S. de Bono, Smith, AD, Bissan Al-Lazikani, Yap, TA, Al-Lazikani, B, Timothy A. Yap, Roberta Ferraldeschi, Alan D. Smith, Ferraldeschi, R, de Bono, JS, Workman, P   +11 more
core   +1 more source

Photochemistry in Flow for Drug Discovery

, 2021
S.71-119The discovery of new drug candidates and the development of new lead structures for future active pharmaceutical ingredients are continuous processes, which combine the expertise of many scientific disciplines.
Rehm, Thomas H., Thomas H. Rehm
core   +1 more source

Discovery of a new drug-like series of OGT inhibitors by virtual screening [PDF]

, 2022
O-GlcNAcylation is an essential post-translational modification installed by the enzyme O-β-N-acetyl-d-glucosaminyl transferase (OGT). Modulating this enzyme would be extremely valuable to better understand its role in the development of serious human ...
Anderluh, Marko, Afd Chemical Biology and Drug Discovery, Elena M. Loi, Matjaž Weiss, David J. Vocadlo, Balsollier, Cyril, Matthew G. Alteen, Chemical Biology and Drug Discovery, Loi, Elena Maria, van Eekelen, Kevin, Kevin van Eekelen, Tihomir Tomašič, Loi, Elena M, Gobec, Martina, Martina Gobec, Tomašič, Tihomir, Roland J. Pieters, Alteen, Matthew G, Weiss, Matjaž, Loi, Elena M., Cyril Balsollier, Marko Anderluh, Vocadlo, David J, Pieters, Roland J., Vocadlo, David J., Alteen, Matthew G., Pieters, Roland J   +26 more
core   +2 more sources