Results 21 to 30 of about 3,678,790 (312)

Profitability and drug discovery

Industrial and Corporate Change, 2022
Abstract Pharmaceutical firms are highly profitable due to high markups enabled by high drug prices. This is justified by the argument that high profits provide incentives for innovation and help fund high research and development (R&D) costs.
Isik, Enes, Orhangazi, Özgür, Orhangazi, Ozgur   +2 more
openaire   +1 more source

Development and validation of a high-throughput calcium mobilization assay for the orphan receptor GPR88

Journal of Biomedical Science, 2017
Background GPR88 is an orphan G protein-coupled receptor highly expressed in the striatum and is implicated in basal ganglia-associated disorders. However, the receptor functions of GPR88 are still largely unknown due to the lack of potent and selective ...
Ann M. Decker, Elaine A. Gay, Kelly M. Mathews, Taylor C. Rosa, Tiffany L. Langston, Rangan Maitra, Chunyang Jin   +6 more
doaj   +1 more source

Drug Discovery in Africa. [PDF]

ACS Med Chem Lett
Dziwornu GA, Cheuka PM, Mayoka G.
europepmc   +3 more sources

Cancer drug discovery: recent innovative approaches to tumor modeling

, 2016
Introduction: Cell culture models have been at the heart of anti-cancer drug discovery programs for over half a century. Advancements in cell culture techniques have seen the rapid evolution of more complex in vitro cell culture models investigated for ...
Lovitt, Carrie J, Avery, Vicky M, Shelper, Todd B   +2 more
core   +1 more source

Natural products in drug discovery: advances and opportunities

, 2021
Natural products and their structural analogues have historically made a major contribution to pharmacotherapy, especially for cancer and infectious diseases.
Atanasov, AG, Zotchev, SB, Dirsch, VM, Yeung, AWK, Supuran, CT, The International Natural Product Sciences Taskforce   +5 more
core   +1 more source

Pharmacological inhibition of nSMase2 reduces brain exosome release and α-synuclein pathology in a Parkinson’s disease model

Molecular Brain, 2021
Aim We have previously reported that cambinol (DDL-112), a known inhibitor of neutral sphingomyelinase-2 (nSMase2), suppressed extracellular vesicle (EV)/exosome production in vitro in a cell model and reduced tau seed propagation.
Chunni Zhu, Tina Bilousova, Samantha Focht, Michael Jun, Chris Jean Elias, Mikhail Melnik, Sujyoti Chandra, Jesus Campagna, Whitaker Cohn, Asa Hatami, Patricia Spilman, Karen Hoppens Gylys, Varghese John   +12 more
doaj   +1 more source

The role of pharmacology in drug discovery.

, 2002
The International Union of Pharmacology (IUPHAR) enthusiastically welcomes the decision by the Nature Publishing Group to launch its new journal, Nature Reviews Drug Discovery. The title of the new journal poses interesting questions for pharmacologists.
Bertil B. Fredholm, Fredholm, Bertil B, Fleming, William W, William W. Fleming, Paul M. Vanhoutte, Théophile Godfraind, Godfraind, T, Godfraind, Theophile, Vanhoutte, PM, Fredholm, BB, Vanhoutte, Paul M, Fleming, WW   +11 more
core   +1 more source

Genetic programming in data mining for drug discovery [PDF]

, 2004
Genetic programming (GP) is used to extract from rat oral bioavailability (OB) measurements simple, interpretable and predictive QSAR models which both generalise to rats and to marketed drugs in humans. Receiver Operating Characteristics (ROC) curves
Barrett, S.J., Langdon, W.B.
core  

Social Functioning Within the First Years After Pediatric Brain Tumor Diagnosis and the Relationship With Family Psychosocial Risk

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Survivors of pediatric brain tumors (PBTs) can experience long‐term social difficulties, impacting quality of life. Beyond medical and environmental factors, family psychosocial risk may play a role in social outcomes by shaping the caregiving environment and may provide intervention options.
Renske H. Houben, Marisa H. Huisman, Martha A. Grootenhuis, Femke K. Aarsen, Marita Partanen   +4 more
wiley   +1 more source

Biological characterization of chemically diverse compounds targeting the Plasmodium falciparum coenzyme A synthesis pathway

Parasites & Vectors, 2016
Background In the fight against malaria, the discovery of chemical compounds with a novel mode of action and/or chemistry distinct from currently used drugs is vital to counteract the parasite’s known ability to develop drug resistance. Another desirable
Sabine Fletcher, Leonardo Lucantoni, Melissa L. Sykes, Amy J. Jones, John P. Holleran, Kevin J. Saliba, Vicky M. Avery   +6 more
doaj   +1 more source