Results 11 to 20 of about 3,490,892 (315)
Machine learning approaches for computer aided drug discovery [PDF]
, 2023 Pharmaceutical drug discovery is expensive, time consuming and scientifically challenging. In order to increase efficiency of the pre-clinical drug discovery pathway, computational drug discovery methods and most recently, machine learning-based methods ...
Moesser, Marc
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Enhancing preclinical drug discovery with artificial intelligence
, 2022 Artificial intelligence (AI) is becoming an integral part of drug discovery. It has the potential to deliver across the drug discovery and development value chain, starting from target identification and reaching through clinical development.
Poongavanam, Vasanthanathan +7 more
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Rapid Discovery of Potent and Selective Glycosidase-Inhibiting De Novo Peptides [PDF]
, 2017 Human pancreatic α-amylase (HPA) is responsible for degrading starch to malto-oligosaccharides, thence to glucose, and is therefore an attractive therapeutic target for the treatment of diabetes and obesity.
Tysoe, Christina +7 more
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Natural products in drug discovery
, 2008 Natural products have been the single most productive source of leads for the development of drugs. Over a 100 new products are in clinical development, particularly as anti-cancer agents and anti-infectives.
Harvey, Alan L
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Fibronectin extra domain A as a drug delivery targeting epitope for rheumatoid arthritis
Advances in Rheumatology, 2022 Objectives To assess the ability of monoclonal antibodies (mAbs) specific for fibronectin extra-domain A (FnEDA) to target diseased tissues of mouse collagen induced arthritis (mCIA) models.
Victor Z. Sun +13 more
doaj +1 more source
Toxins and drug discovery [PDF]
Toxicon, 2014 Components from venoms have stimulated many drug discovery projects, with some notable successes. These are briefly reviewed, from captopril to ziconotide. However, there have been many more disappointments on the road from toxin discovery to approval of a new medicine. Drug discovery and development is an inherently risky business, and the main causes
openaire +4 more sources
Conversion of Aquaculture Waste into Biomedical Wealth: Chitin and Chitosan Journey
Advances in Materials Science and Engineering, 2022 Biowaste originating from aquaculture sector represents a potential feedstock to produce value-added substances and materials like chitin and chitosan. They are the long chain polymers of N-acetylglucosamine polymers with huge industrial and biomedical ...
Jerrine Joseph +8 more
doaj +1 more source
Screening a protein kinase inhibitor library against Plasmodium falciparum
Malaria Journal, 2017 Background Protein kinases have been shown to be key drug targets, especially in the area of oncology. It is of interest to explore the possibilities of protein kinases as a potential target class in Plasmodium spp., the causative agents of malaria ...
Irene Hallyburton +12 more
doaj +1 more source
Natural products in drug discovery: advances and opportunities
, 2021 Natural products and their structural analogues have historically made a major contribution to pharmacotherapy, especially for cancer and infectious diseases.
Atanasov, AG +5 more
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Bioinformatics and Drug Discovery [PDF]
Current Topics in Medicinal Chemistry, 2017 Bioinformatic analysis can not only accelerate drug target identification and drug candidate screening and refinement, but also facilitate characterization of side effects and predict drug resistance. High-throughput data such as genomic, epigenetic, genome architecture, cistromic, transcriptomic, proteomic, and ribosome profiling data have all made ...
openaire +2 more sources