Results 11 to 20 of about 658,841 (317)
Atlas for drug discovery [PDF]
Proceedings of the National Academy of Sciences, 2014 Reports of increasing antibiotic resistance and sagging drug discovery rates are appearing with increasing frequency, and many warn that we are living on the wrong side of an antibiotic peak—a period in which ever-fewer new antibiotics are being discovered at ever-increasing costs (1).
Pierre, Stallforth, Jon, Clardy
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Current Opinion in Structural Biology, 2023 The cryo-electron microscopy (cryo-EM) method microcrystal electron diffraction (MicroED) was initially described in 2013 and has recently gained attention as an emerging technique for research in drug discovery. As compared to other methods in structural biology, MicroED provides many advantages deriving from the use of nanocrystalline material for ...
Emma Danelius +3 more
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Computational drug discovery [PDF]
Acta Pharmacologica Sinica, 2012 Computational drug discovery is an effective strategy for accelerating and economizing drug discovery and development process. Because of the dramatic increase in the availability of biological macromolecule and small molecule information, the applicability of computational drug discovery has been extended and broadly applied to nearly every stage in ...
Si-Sheng, Ou-Yang +5 more
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RSC Medicinal Chemistry, 2020 Innovations in mycobacterial drug discovery to accelerate the identification of new drug candidates with confirmed targets and whole cell activity.
Katherine A. Abrahams, Gurdyal S. Besra
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Discovery of Antiepileptic Drugs [PDF]
Neurotherapeutics, 2007 Since 1993, the Anticonvulsant Drug Development Program has contributed to the successful development of nine clinically effective drugs for the symptomatic treatment of epilepsy. These include felbamate (1993), gabapentin (1994), lamotrigine (1994), fosphenytoin (1996), topiramate (1996), tiagabine (1997), levetiracetam (1999), zonisamide (2000), and ...
Misty, Smith +2 more
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Screening a protein kinase inhibitor library against Plasmodium falciparum
Malaria Journal, 2017 Background Protein kinases have been shown to be key drug targets, especially in the area of oncology. It is of interest to explore the possibilities of protein kinases as a potential target class in Plasmodium spp., the causative agents of malaria ...
Irene Hallyburton +12 more
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Toxins and drug discovery [PDF]
Toxicon, 2014 Components from venoms have stimulated many drug discovery projects, with some notable successes. These are briefly reviewed, from captopril to ziconotide. However, there have been many more disappointments on the road from toxin discovery to approval of a new medicine. Drug discovery and development is an inherently risky business, and the main causes
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Profitability and drug discovery
Industrial and Corporate Change, 2022 Abstract Pharmaceutical firms are highly profitable due to high markups enabled by high drug prices. This is justified by the argument that high profits provide incentives for innovation and help fund high research and development (R&D) costs.
Isik, Enes +2 more
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Journal of Biomedical Science, 2017 Background GPR88 is an orphan G protein-coupled receptor highly expressed in the striatum and is implicated in basal ganglia-associated disorders. However, the receptor functions of GPR88 are still largely unknown due to the lack of potent and selective ...
Ann M. Decker +6 more
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Molecular Brain, 2021 Aim We have previously reported that cambinol (DDL-112), a known inhibitor of neutral sphingomyelinase-2 (nSMase2), suppressed extracellular vesicle (EV)/exosome production in vitro in a cell model and reduced tau seed propagation.
Chunni Zhu +12 more
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