Results 31 to 40 of about 6,006,073 (362)
Protein-protein interaction modulator drug discovery [PDF]
, 2022 S.1393-1404Introduction: Historically, small-molecule drug discovery projects have largely focused on the G-protein-coupled receptor, ion-channel and enzyme target classes.
Hadian, K., Gul, S.
core +1 more source
Scientific Reports, 2021 Activation of the tyrosine kinase with Ig and epidermal growth factor homology domain 2 (Tie2) receptor by angiopoietin-1 (Ang1) is critical for vascular stabilization: it promotes survival signal transduction via auto-phosphorylation and reduces ...
Yukari Koya +4 more
doaj +1 more source
Antimalarial drug discovery: progress and approaches
Nature reviews. Drug discovery, 2023 Recent antimalarial drug discovery has been a race to produce new medicines that overcome emerging drug resistance, whilst considering safety and improving dosing convenience.
Jair L. Siqueira-Neto +5 more
semanticscholar +1 more source
Functional pharmacology: the drug discovery bottleneck? [PDF]
, 2004 It is our contention that functional pharmacology, particularly in vivo, must play a greater role in drug discovery if the promises of reductionist techniques are to be brought to full fruition.
core +1 more source
Drug discovery and development: introduction to the general public and patient groups
Frontiers in Drug Discovery, 2023 Finding new drugs usually consists of five main stages: 1) a pre-discovery stage in which basic research is performed to try to understand the mechanisms leading to diseases and propose possible targets (e.g., proteins); 2) the drug discovery stage ...
Natesh Singh +5 more
semanticscholar +1 more source
Discovery of Antiepileptic Drugs [PDF]
Neurotherapeutics, 2007 Since 1993, the Anticonvulsant Drug Development Program has contributed to the successful development of nine clinically effective drugs for the symptomatic treatment of epilepsy. These include felbamate (1993), gabapentin (1994), lamotrigine (1994), fosphenytoin (1996), topiramate (1996), tiagabine (1997), levetiracetam (1999), zonisamide (2000), and ...
Misty, Smith +2 more
openaire +2 more sources
Cancer drug discovery: recent innovative approaches to tumor modeling [PDF]
, 2016 Introduction: Cell culture models have been at the heart of anti-cancer drug discovery programs for over half a century. Advancements in cell culture techniques have seen the rapid evolution of more complex in vitro cell culture models investigated for ...
Avery, Vicky +5 more
core +1 more source
Photochemistry in Flow for Drug Discovery [PDF]
, 2021 S.71-119The discovery of new drug candidates and the development of new lead structures for future active pharmaceutical ingredients are continuous processes, which combine the expertise of many scientific disciplines.
Rehm, Thomas H., Thomas H. Rehm
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Journal of Translational Medicine, 2016 Background Angiopoietin-2 (Ang-2), a ligand of the Tie-2 receptor, plays an important role in maintaining endothelial cells and in destabilizing blood vessels. Collateral artery growth (arteriogenesis) is a key adaptive response to arterial occlusion. It
Xiaoyong Tan +11 more
doaj +1 more source
Fibronectin extra domain A as a drug delivery targeting epitope for rheumatoid arthritis
Advances in Rheumatology, 2022 Objectives To assess the ability of monoclonal antibodies (mAbs) specific for fibronectin extra-domain A (FnEDA) to target diseased tissues of mouse collagen induced arthritis (mCIA) models.
Victor Z. Sun +13 more
doaj +1 more source