Results 31 to 40 of about 3,678,790 (312)

Anticancer Drug Discovery [PDF]

JNCI Journal of the National Cancer Institute, 1991
The National Cancer Institute's (NCI's) human tumor cell line panel for screening potential new anticancer drugs is now operational (/). Its implementation and the demonstration of its feasibility represent a technical and organizational tour de force.
openaire   +2 more sources

Positron emission tomographic imaging in drug discovery

, 2022
Positron emission tomography (PET) is an extensively used nuclear functional imaging technique, especially for central nervous system (CNS) and oncological disorders. Currently, drug development is a lengthy and costly pursuit.
Palanivel, Mathangi, Ghosh, Krishna Kanta, Mishra, Sachin, Ghosh, KK, Padmanabhan, P, Yang, Chang-Tong, Halldin, Christer, Gulyas, B, Padmanabhan, Parasuraman, Halldin, C,, Gulyás, Balázs, Mishra, S, Palanivel, M, Yang, C-T, Ng, DCE, Krishna Kanta Ghosh, Parasuraman Padmanabhan, David Chee Eng Ng, Sachin Mishra, Mathangi Palanivel, Balázs Gulyás, Chang-Tong Yang, Christer Halldin   +22 more
core   +1 more source

Retrospective Analysis of Donor Lymphocyte Infusions in Pediatric Patients With Mixed Chimerism After Hematopoietic Stem Cell Transplantation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Allogeneic hematopoietic stem cell transplantation (alloHSCT) is an essential therapy for several malignant and nonmalignant diseases, but relapse and graft loss remain the principal threats to its success. Routine monitoring of chimerism and minimal residual disease (MRD) enables early detection of imminent recurrence and guides ...
Carmen Junk, Sebastian Michaelis, Michaela Döring, Thomas Eichholz, Ursula Holzer, Martin Ebinger, Tim Flaadt, Rupert Handgretinger, Peter Lang, Jan Frederic Weller, Markus Mezger   +10 more
wiley   +1 more source

Discovery and binding mode of small molecule inhibitors of the apo form of human TDO2

Scientific Reports
Tryptophan-2,3-dioxygenase (TDO2) and indoleamine-2,3-dioxygenase (IDO1) are structurally distinct heme enzymes that catalyze the conversion of L-tryptophan to N-formyl-kynurenine, and play important roles in metabolism, inflammation, and tumor immune ...
Carina Lotz-Jenne, Roland Lange, Sylvaine Cren, Geoffroy Bourquin, Laksmei Goglia, Thierry Kimmerlin, Micha Wicki, Manon Müller, Nadia Artico, Sabine Ackerknecht, Philippe Pfaff, Christoph Joesch, Aengus Mac Sweeney   +12 more
doaj   +1 more source

Inhibition of triple negative breast cancer-associated inflammation, tumor growth and brain colonization by targeting monoacylglycerol lipase

Scientific Reports, 2022
While the prevalence of breast cancer metastasis in the brain is significantly higher in triple negative breast cancers (TNBCs), there is a lack of novel and/or improved therapies for these patients. Monoacylglycerol lipase (MAGL) is a hydrolase involved
Othman Benchama, Sergiy Tyukhtenko, Michael S. Malamas, Mark K. Williams, Alexandros Makriyannis, Hava Karsenty Avraham   +5 more
doaj   +1 more source

Drug discovery in advanced prostate cancer: translating biology into therapy [PDF]

, 2016
Castration-resistant prostate cancer (CRPC) is associated with a poor prognosis and poses considerable therapeutic challenges. Recent genetic and technological advances have provided insights into prostate cancer biology and have enabled the ...
Paul Workman, Johann S. de Bono, Smith, AD, Bissan Al-Lazikani, Yap, TA, Al-Lazikani, B, Timothy A. Yap, Roberta Ferraldeschi, Alan D. Smith, Ferraldeschi, R, de Bono, JS, Workman, P   +11 more
core   +1 more source

Protein-protein interaction modulator drug discovery

, 2022
S.1393-1404Introduction: Historically, small-molecule drug discovery projects have largely focused on the G-protein-coupled receptor, ion-channel and enzyme target classes.
Hadian, K., Gul, S.
core   +1 more source

Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin‐6 (IL‐6) inhibitor, is the only FDA‐approved treatment for adult patients with iMCD.
Bridget Austin, Sheila K. Pierson, Kelley C. Dacus, Mateo Sarmiento Bustamante, Saishravan Shyamsundar, Larissa Borys, Kayla McHugh, Abiola Irvine, Yoojin Jo, Adam Bagg, Mary Jo Lechowicz, Daisy Alapat, Amy Chadburn, Megan S. Lim, Gordan Srkalovic, Frits van Rhee, David C. Fajgenbaum, Joshua D. Brandstadter   +17 more
wiley   +1 more source

A novel anti-NGF PEGylated Fab’ provides analgesia with lower risk of adverse effects

mAbs, 2023
Nerve growth factor (NGF) has emerged as a key driver of pain perception in several chronic pain conditions, including osteoarthritis (OA), and plays an important role in the generation and survival of neurons.
Yukari Koya, Hirotsugu Tanaka, Eiji Yoshimi, Nobuaki Takeshita, Shuji Morita, Hiroki Morio, Kanako Mori, Hiroshi Fushiki, Masazumi Kamohara   +8 more
doaj   +1 more source

Glycans in drug discovery

MedChemComm, 2019
Exploiting glycan recognition in drug discovery.
Pablo Valverde, Ana Ardá, Niels-Christian Reichardt, Jesús Jiménez-Barbero, Ana Gimeno   +4 more
openaire   +4 more sources