Results 51 to 60 of about 6,006,073 (362)
Artificial intelligence to deep learning: machine intelligence approach for drug discovery
Molecular diversity, 2021 Drug designing and development is an important area of research for pharmaceutical companies and chemical scientists. However, low efficacy, off-target delivery, time consumption, and high cost impose a hurdle and challenges that impact drug design and ...
Rohan Gupta +5 more
semanticscholar +1 more source
Podophyllotoxin derivatives: drug discovery and development [PDF]
, 1996 The exploration and exploitation of podophyllin formulations provide an example of how a plant extract with established ethnomedical use, but also causing toxicity, can provide a basis for new drug discovery and development.
Bohlin, Lars, +3 more
core +1 more source
Journal of Biomedical Science, 2017 Background GPR88 is an orphan G protein-coupled receptor highly expressed in the striatum and is implicated in basal ganglia-associated disorders. However, the receptor functions of GPR88 are still largely unknown due to the lack of potent and selective ...
Ann M. Decker +6 more
doaj +1 more source
Drug discovery from uncultivable microorganisms [PDF]
, 2010 Environmental microbes are a major source of drug discovery, and several microbial products (antibiotics, anti-tumour products, immunosuppressants and others) are used routinely for human therapies. Most of these products were obtained from cultivable (
Macdonald, Catriona A. (R16704) +5 more
core +1 more source
Modulating biomolecular condensates: a novel approach to drug discovery
Nature reviews. Drug discovery, 2022 In the past decade, membraneless assemblies known as biomolecular condensates have been reported to play key roles in many cellular functions by compartmentalizing specific proteins and nucleic acids in subcellular environments with distinct properties ...
Diana M. Mitrea +4 more
semanticscholar +1 more source
Future challenges with DNA-encoded chemical libraries in the drug discovery domain [PDF]
, 2019 Introduction: DNA-encoded chemical libraries (DELs) have come of age and emerged to become a powerful technology platform for ligand discovery in biomedical research and drug discovery.
Zhao, G, HUANG, Y, Li, Y, Li, X, Zhou, Y
core +1 more source
Assay development in leishmaniasis drug discovery: a comprehensive review [PDF]
, 2021 Introduction: Cutaneous, muco-cutaneous and visceral leishmaniasis occur due to an infection with the protozoan parasite Leishmania. The current therapeutic options are limited mainly due to extensive toxicity, emerging resistance and variation in ...
Zulfiqar, Bilal, Avery, Vicky M
core +1 more source
Artificial intelligence in cancer target identification and drug discovery
Signal Transduction and Targeted Therapy, 2022 Artificial intelligence is an advanced method to identify novel anticancer targets and discover novel drugs from biology networks because the networks can effectively preserve and quantify the interaction between components of cell systems underlying ...
Yujie You +7 more
semanticscholar +1 more source
Molecular Brain, 2021 Aim We have previously reported that cambinol (DDL-112), a known inhibitor of neutral sphingomyelinase-2 (nSMase2), suppressed extracellular vesicle (EV)/exosome production in vitro in a cell model and reduced tau seed propagation.
Chunni Zhu +12 more
doaj +1 more source
Plant-Derived Natural Products: A Source for Drug Discovery and Development
Drugs and Drug CandidatesFor thousands of years, nature has been a source of medical substances, and an astounding numeral of contemporary remedies have been identified from natural origins.
N. Chaachouay, L. Zidane
semanticscholar +1 more source