Results 81 to 90 of about 6,006,073 (362)

Capturing mixture composition: an open machine-readable format for representing mixed substances

Journal of Cheminformatics, 2019
We describe a file format that is designed to represent mixtures of compounds in a way that is fully machine readable. This Mixfile format is intended to fill the same role for substances that are composed of multiple components as the venerable Molfile ...
Alex M. Clark, Leah R. McEwen, Peter Gedeck, Barry A. Bunin   +3 more
doaj   +1 more source

Incidence and Severity of Carboplatin‐Associated Hearing Loss in Children With Cancer Assessed by the SIOP Boston 2012 Ototoxicity Criteria

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Platinum‐based chemotherapy is known to cause severe and debilitating hearing loss, but unlike cisplatin, the true incidence of carboplatin‐induced hearing loss remains unclear. We evaluated functional hearing outcomes in children receiving carboplatin to determine the incidence and severity of ototoxicity. Procedure We identified a
Aniket Chawla, Sean Carter, Andrew Wood, Sandra Staffieri, Andrew Dodgshun, David D. Eisenstat, Michael Sullivan   +6 more
wiley   +1 more source

Synthetic and Mechanistic Studies with Lipopeptide Antibiotics [PDF]

, 2018
The cyclic lipopeptides comprise a number of clinically relevant classes of antibiotics that date back from the discovery of the polymyxins in 1947 to the recent introduction of the lipoglycopeptides.
Afd Chemical Biology and Drug Discovery, Kleijn, L.H.J., Chemical Biology and Drug Discovery   +2 more
core  

Drug discovery in advanced prostate cancer: translating biology into therapy [PDF]

, 2016
Castration-resistant prostate cancer (CRPC) is associated with a poor prognosis and poses considerable therapeutic challenges. Recent genetic and technological advances have provided insights into prostate cancer biology and have enabled the ...
Paul Workman, Johann S. de Bono, Smith, AD, Bissan Al-Lazikani, Yap, TA, Al-Lazikani, B, Timothy A. Yap, Roberta Ferraldeschi, Alan D. Smith, Ferraldeschi, R, de Bono, JS, Workman, P   +11 more
core   +2 more sources

Herbomineral Medicine Peedanil Gold Exerts Analgesia in Neuropathy by Moderating Inflammatory Response and TRP Channel Expression in Sprague Dawley Rat Surgical Chronic Constriction Injury Model

Pain Research and Management
Conclusions: Altogether, the outcomes from the current study prove that PN-G is an effective antineuropathic agent with potential to manage pain as well as eliminate the underlying cause of neuroinflammation behind the chronicity of neuropathic pain.
Acharya Balkrishna, Shadrak Karumuri, Sandeep Sinha, Rani Singh, Rishabh Dev, Swati Haldar, Anurag Varshney   +6 more
doaj   +1 more source

Re‐Irradiation in Pediatric Diffuse Midline Glioma: A Multi‐Institutional Retrospective Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Children with recurrent diffuse midline gliomas (DMGs) have limited therapeutic options at recurrence. Re‐irradiation (RT2) may be used at progression, but with uncertainty about the benefit. Methods We conducted a multi‐institutional retrospective study of children aged < 18 with DMG treated at three centers (Toronto, Canada ...
Ajay Thomas Alex, Sean P. Hassan, Helen Benghiat, Liam Herbert, Jennifer Adamski, Shivani Bailey, Claire Esler, Louise Brookes, Molly Bamber, Grace Koudou, Karen Waite, Julie Bennett, Anirban Das, Derek S. Tsang   +13 more
wiley   +1 more source

Leishmaniasis drug discovery: Recent progress and challenges in assay development [PDF]

, 2017
Leishmaniasis, caused by the trypanosomatid protozoan Leishmania, is endemic in 98 countries worldwide, with morbidity and mortality increasing daily. Despite available drugs, leishmaniasis faces the challenge of emerging resistance and toxicity concerns
Todd B. Shelper, Zulfiqar, Bilal, Avery, Vicky, Bilal Zulfiqar, Zulfigar, Bilal, Vicky M. Avery, Shelper, Todd, Avery, Vicky M, Shelper, Todd B   +8 more
core   +1 more source

Nonclinical Safety Evaluation of Renogrit: In Vitro Nonmutagenicity (OECD 471) and 28-Day Repeated Oral Dose Toxicity (OECD 407) in Sprague Dawley Rats

Journal of Toxicology
Renogrit is a prescription medicine developed by employing the traditional knowledge of Ayurveda for the management of kidney disorders. To support its extensive clinical investigations, Renogrit requires robust nonclinical safety assessments ...
Acharya Balkrishna, Aakanksha Tiwari, Himanshu Jangid, Kamaraj Mani, Savita Lochab, Sandeep Sinha, Anurag Varshney   +6 more
doaj   +1 more source

Edible Pueraria lobata-Derived Exosomes Promote M2 Macrophage Polarization

Molecules, 2022
Pueraria lobata (known as Gegen) is an edible and medicinal herb that is a nutritious medicine food homology plant in China. Previous studies indicated that P. lobata plays an essential role in controlling cytokines.
Jiaqi Wu, Xiaoyu Ma, Yu Lu, Tao Zhang, Zuoqin Du, Jin Xu, Jingcan You, Ni Chen, Xin Deng, Jianbo Wu   +9 more
doaj   +1 more source

Phenotypic Drug Discovery: Recent successes, lessons learned and new directions

Nature reviews. Drug discovery, 2022
Many drugs, or their antecedents, were discovered through observation of their effects on normal or disease physiology. For the past generation, this phenotypic drug discovery approach has been largely supplanted by the powerful but reductionist approach
F. Vincent, Arsenio Nueda, Jonathan Lee, M. Schenone, M. Prunotto, M. Mercola   +5 more
semanticscholar   +1 more source