Results 81 to 90 of about 1,396,646 (189)

In mouse model of mixed granulocytic asthma with corticosteroid refractoriness, Bronchom mitigates airway hyperresponsiveness, inflammation and airway remodeling

Molecular Medicine
Background Asthma is a heterogeneous, inflammatory disease with several phenotypes and endotypes. Severe asthmatics often exhibit mixed granulocytosis with reduced corticosteroid sensitivity. Bronchom is a newly developed Ayurvedic prescription medicine,
Acharya Balkrishna, Sandeep Sinha, Anupam Pandey, Surjeet Singh, Monali Joshi, Rani Singh, Anurag Varshney   +6 more
doaj   +1 more source

Drug Discovery [PDF]

Science, 2004
openaire   +2 more sources

Functional Characterization and Mutagenesis Studies of a Microbial-like Diterpene Synthase from Huperzia serrata

Molecules
Over the past decade, an increasing number of functional microbial-like terpene synthases (MTPSLs) have been reported in non-seed plants. However, whether the traditional Chinese medicinal plant H.
Ting He, Yao Zhao, Xin Li, Bao Chen, Fangyan Chen, Baofu Xu   +5 more
doaj   +1 more source

An allosteric inhibitor of the Zika virus NS2B-NS3 protease with oral efficacy in mouse models

Nature Communications
The mosquito-transmitted Zika virus (ZIKV) poses a global health threat, with no approved antiviral drugs or vaccines currently available. Here, we report the discovery of a series of ZIKV NS3 protease inhibitors identified through phenotypic high ...
Jesus M. Ontoria, Esther Torrente, Antonino Missineo, Cristina Alli, Rita Graziani, Silvia Conti, Monica Bisbocci, Antonio Quotadamo, Federica Ferrigno, Alessandra Corio, Giovanni Ievoli, Leda Bencheva, Jérôme Amaudrut, Silvana Vasile, Elisa Beghetto, Chantal Paolini, Nadine Alaimo, Maria Veneziano, Martina Nibbio, Maria V. Orsale, Giulia Proto, Fabrizio Colaceci, Laura Orsatti, Vincenzo Pucci, Romano Di Fabio, Licia Tomei, Christian Montalbetti, Alberto Bresciani, Carlo Toniatti, Giacomo Paonessa   +29 more
doaj   +1 more source

Enhancing anti-tumor immunity through co-blocking PD-L1 and TIGIT by facilitating tumor-directed responses and additional VEGF inhibition

Frontiers in Immunology
Combination therapy targeting the PD-1/PD-L1 and TIGIT pathways has been explored to enhance the efficacy of current immunotherapies. In this study, we investigated strategies to further potentiate the co-blockade of PD-L1 and TIGIT for cancer ...
Xi Zhu, Xiaopei Cui, Haijia Yu, Jingen Xu, Xiaofang Chen, Xiaochen Ren, Xiaochen Ren, Xiaoyue Wei, Shi Chen, Yangtin Wang, Liyang Fei, Liyang Fei, Bin Xie, Mingwei Li, Xue Li, Huifeng Jia, Yujie Feng, Simin Xia, Li Chen, Yong Cheng, Lei Zhang, Haidong Li, Xiangyang Zhu, Yifan Zhan   +23 more
doaj   +1 more source

Thyrogrit, supplemented with a sub-optimal dose of levothyroxine, restores thyroid function in rat model of propylthiouracil-induced hypothyroidism

Clinical Phytoscience
Background Hypothyroidism is a common endocrine ailment, whose current standard of care is hormonal replacement therapy with levothyroxine (LT4). There is a medical need for alternative and safer therapies as LT4 is associated with special treatment ...
Acharya Balkrishna, Ritu Paliwal, Madhulina Maity, Yash Varshney, Sandeep Sinha, Anurag Varshney   +5 more
doaj   +1 more source

Experience from an HTS campaign: Investigation of susceptibility and rescue of SARS-CoV-2 nsp3 protease assay from metal contamination

SLAS Technology
Different biochemical assays yield different rates of false positives than others either due to the nature of the enzyme, the technology associated with the bioassay, or properties of the compounds being screened.
Irene Georgiou, Sandra O’Neill, Colin Robinson, Fraser Cunningham, Sean N. O’Byrne, David Gray, Ian H. Gilbert, Duncan E. Scott   +7 more
doaj   +1 more source

Accelerating Drug Discovery [PDF]

Nature Biotechnology, 1994
openaire   +2 more sources

TamGen: drug design with target-aware molecule generation through a chemical language model

Nature Communications
Generative drug design facilitates the creation of compounds effective against pathogenic target proteins. This opens up the potential to discover novel compounds within the vast chemical space and fosters the development of innovative therapeutic ...
Kehan Wu, Yingce Xia, Pan Deng, Renhe Liu, Yuan Zhang, Han Guo, Yumeng Cui, Qizhi Pei, Lijun Wu, Shufang Xie, Si Chen, Xi Lu, Song Hu, Jinzhi Wu, Chi-Kin Chan, Shawn Chen, Liangliang Zhou, Nenghai Yu, Enhong Chen, Haiguang Liu, Jinjiang Guo, Tao Qin, Tie-Yan Liu   +22 more
doaj   +1 more source

Lipid‐Based Nanoplatforms in Hepatology: From Rational Design to Clinical Translation Challenges

MedComm – Biomaterials and Applications
Liver diseases—encompassing hepatitis, liver fibrosis, fatty liver, and hepatocellular carcinoma—constitute a formidable global health challenge. Existing treatments are often limited by several key issues, such as low drug accumulation, poor selectivity
Jie Wang, Qian Zhang, Lin Yang, Zijian Cheng, Chunhong Wang, Runlin Song, Honglan Dai, Xinxin Zhang   +7 more
doaj   +1 more source