Results 81 to 90 of about 3,678,790 (312)
Muropeptides and muropeptide transporters impact on host immune response
Gut MicrobesIn bacteria, the cell envelope is the key element surrounding and protecting the bacterial content from mechanical or osmotic damages. It allows the selective interchanges of solutes, ions, cellular debris, and drugs between the cellular compartments and
Maria Lucia Orsini Delgado +3 more
doaj +1 more source
Venturing into drug discovery [PDF]
Nature Biotechnology, 1998 Biotechnology now has an established role in drug discovery, but the best opportunities are yet to come.
openaire +2 more sources
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Why are olfactory ensheathing cell tumors so rare?
Cancer Cell International, 2019 The glial cells of the primary olfactory nervous system, olfactory ensheathing cells (OECs), are unusual in that they rarely form tumors. Only 11 cases, all of which were benign, have been reported to date.
Mariyam Murtaza +7 more
doaj +1 more source
Bioinformatics and Drug Discovery [PDF]
Current Topics in Medicinal Chemistry, 2017 Bioinformatic analysis can not only accelerate drug target identification and drug candidate screening and refinement, but also facilitate characterization of side effects and predict drug resistance. High-throughput data such as genomic, epigenetic, genome architecture, cistromic, transcriptomic, proteomic, and ribosome profiling data have all made ...
openaire +2 more sources
A renaissance of neural networks in drug discovery [PDF]
, 2016 © 2016 Informa UK Limited, trading as Taylor & Francis Group.Introduction: Neural networks are becoming a very popular method for solving machine learning and artificial intelligence problems.
Winkler D., Baskin I., Tetko I.
core
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Significant impacts of metal ions from ancient oceans on nucleoside phosphorylation
BMC ChemistryNucleotides, such as 5’-AMP and ATP, are essential biomolecules in modern organisms. The phosphorylation of nucleosides to generate nucleotides occurs in complex prebiotic environments, where metal ions played a pivotal role, particularly in the metal ...
Qian Wu +6 more
doaj +1 more source
Fragment-Based Drug Discovery: a Practical Approach
, 2009 This book presents a company-based view of the recent progresses in fragment-based drug discovery (FBDD). The book is highly focussed on methodologies.
Giulio Rastelli, RASTELLI, Giulio
core +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source