Results 81 to 90 of about 3,490,892 (315)
BMC BiologyBackground Cyclic Nucleotide-Binding Domain (CNBD)-family channels display distinct voltage-sensing properties despite sharing sequence and structural similarity.
Zhipei Liu +14 more
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Gaps between medical biology and AI drug discovery
Drug discovery is a complex, iterative process spanning biology, chemistry, pharmacology, and computational sciences. Artificial intelligence (AI) can accelerate this process but often misaligns with biological realities. Here, we highlight three crucial
Wang, Lipo, Yin, Yueming, Fu, Afu F.
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Drug discovery from uncultivable microorganisms
, 2010 Environmental microbes are a major source of drug discovery, and several microbial products (antibiotics, anti-tumour products, immunosuppressants and others) are used routinely for human therapies. Most of these products were obtained from cultivable (
Macdonald, Catriona A. (R16704) +5 more
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Practical considerations for active machine learning in drug discovery
, 2020 Active machine learning enables the automated selection of the most valuable next experiments to improve predictive modelling and hasten active retrieval in drug discovery.
Reker, Daniel
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Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
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Significant impacts of metal ions from ancient oceans on nucleoside phosphorylation
BMC ChemistryNucleotides, such as 5’-AMP and ATP, are essential biomolecules in modern organisms. The phosphorylation of nucleosides to generate nucleotides occurs in complex prebiotic environments, where metal ions played a pivotal role, particularly in the metal ...
Qian Wu +6 more
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Development of a Zebrafish Sepsis Model for High-Throughput Drug Discovery
Molecular Medicine, 2017 Sepsis is a leading cause of death worldwide. Current treatment modalities remain largely supportive. Intervention strategies focused on inhibiting specific mediators of the inflammatory host response have been largely unsuccessful, a consequence of an ...
Anju M. Philip +8 more
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The processes of reform in Victoria’s alcohol and other drug sector, 2011-2014 [PDF]
, 2014 This paper explores issues and concerns related to the 2014 alcohol and other drug sector recommissioning process in Victoria. Overview In mid-2014, the Victorian Alcohol and Drug Association approached the Drug Policy Modelling Program, at the ...
Drug Policy Modelling Program
core
Leishmaniasis drug discovery: Recent progress and challenges in assay development
, 2017 Leishmaniasis, caused by the trypanosomatid protozoan Leishmania, is endemic in 98 countries worldwide, with morbidity and mortality increasing daily. Despite available drugs, leishmaniasis faces the challenge of emerging resistance and toxicity concerns
Todd B. Shelper +8 more
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Thiol-Containing Metallo-β-Lactamase Inhibitors Resensitize Resistant Gram-Negative Bacteria to Meropenem [PDF]
, 2017 The prevalence of infections caused by metallo-β-lactamase (MBL) expressing Gram-negative bacteria has grown at an alarming rate in recent years. Despite the fact that MBLs can deactivate virtually all β-lactam antibiotics, there are as of yet no ...
Afd Chemical Biology and Drug Discovery +3 more
core +2 more sources