Results 191 to 200 of about 658,841 (317)

Drug Discovery Targeting Nicotinic Acetylcholine Receptors for Hearing Loss. [PDF]

Int J Mol Sci
Oman J, Sapkota P, Mateen S, Schulte M, Pashikanti S.   +4 more
europepmc   +1 more source

Improving Compound Selection in Drug Discovery: A Quantitative Approach for Biased Data Modelling

Shema Shirley Mamachen
openalex   +2 more sources

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

A Unified, High-Dimensional Drug Dataset Integrating Major Pharmacological Databases to Support AI-Driven Drug Discovery and Development

Safvara Mansuri, Raed Khashan
openalex   +1 more source

Application of Protein Modeling to Drug Discovery

, 2004
Atsushi Inoue, Yoshiyuki Kawakami
openalex   +2 more sources

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Antiviral drug discovery and development: challenges and future directions. [PDF]

Signal Transduct Target Ther
Du S, Hu X, Li P, Xu S, Kim M, Liu X, Zhan P.   +6 more
europepmc   +1 more source

Assessing LLMs for Serendipity Discovery in Knowledge Graphs: A Case for Drug Repurposing

Association for Artificial Intelligence 2026, Evren Gürkan-Çavusoglu, Shrinidhi Hegde, Ao Jiao, Tuo Liang, Pengjun Lu, Chenhui Ma, Mengying Wang, Yinghui Wu, Yu Yin   +9 more
openalex   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

From Virtual Molecules to Clinical Trials: How AI Is Reshaping Preclinical Drug Discovery. [PDF]

J Med Internet Res
Cuffari B.
europepmc   +1 more source