Results 171 to 180 of about 3,678,790 (312)

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Special Issue "Natural Products in Drug Discovery and Development: 2nd Edition". [PDF]

Int J Mol Sci
Gao TL.
europepmc   +1 more source

Accelerating drug discovery [PDF]

The EMBO Reports, 2004
Sandra, Kraljevic, Peter J, Stambrook, Kresimir, Pavelic   +2 more
openaire   +2 more sources

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

MRI in drug discovery

, 2012
MRI is in widespread use in clinical diagnosis as well as in research areas such as preclinical drug discovery. MRI allows non-invasive acquisition of tomographic images of animal soft tissue with high resolution and contrast.
Allegrini, Peter Roland
core  

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

FEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph, Andrea B. Pham, Kiara E. Bornes, Razan H. Hammad, Chelsea A. Rousseve‐Ross, Thomas M. Huckaba, Terry J. Watt, Tasha B. Toro   +7 more
wiley   +1 more source

Advancing Drug Discovery Through Mechanistic Validation and Translational Evaluation. [PDF]

Biomedicines
Nael MA, Alakonda LM, Elokely KM.
europepmc   +1 more source

Protein discovery technologies / [edited by] Renata Pasqualini and Wadih Arap.

, 2009
Includes bibliographical references and index.Book fair 2013.xv, 246 p. :A True Insider’s Guide to the Field – Then and Now Until now, there has not been a book that effectively addresses the historical basis of protein discovery.
Arap, Wadih., Pasqualini, Renata.
core  

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

A Multi-Scale Computational Framework for Anti-Persister Tuberculosis Drug Discovery. [PDF]

Chem Biol Drug Des
Moshawih S, Moulishankar A, Choo CY, Goh KW, Ardianto C, Idris AC, Ming LC.   +6 more
europepmc   +1 more source