Results 161 to 170 of about 658,841 (317)

Improving productivity of modern-day drug discovery [PDF]

, 2013
Matthew D. Breyer
openalex   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Generative AI in structure-based drug discovery. [PDF]

BMC Biol
Zhong Z, Durrant JD.
europepmc   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Leveraging conformational ensembles in allosteric drug discovery. [PDF]

Trends Pharmacol Sci
Nussinov R, Regev C, Jang H.
europepmc   +1 more source

NRM spectroscopy in drug discovery : application and development of NMR based methodologies for P450BM3 drug metabolism, metabolite identification and mixture analysis

, 2013
A.J. Kolkman
openalex   +1 more source

I-31 Prenyltransferases as targets for antibiotic drug discovery

, 2008
A.H.J. Wang
openalex   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Multi-omics and artificial intelligence for precision drug discovery and potential clinical applications. [PDF]

Signal Transduct Target Ther
Liu Y, Zhu K, Peng W, Liu Z, Mao X.
europepmc   +1 more source

Accelerating the discovery of drugs for Neglected Tropical Diseases using biophysical methods

, 2020
Giulia Opassi
openalex   +1 more source