Results 151 to 160 of about 658,841 (317)

Impact of structural biologists and the Protein Data Bank on small-molecule drug discovery and development

, 2021
S.K. Burley
openalex   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Zebrafish Models of Parkinson's Disease: From Pathogenesis to Drug Discovery. [PDF]

Int J Mol Sci
Park HC, Seo Y, Han YJ, Cho SH, Kim MJ.
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Stabilizing Plasmodium falciparum proteins for small molecule drug discovery. [PDF]

Protein Sci
Amann M, Sträßer T, Einsle O, Günther S.   +3 more
europepmc   +1 more source

SAR Matrix Analysis: From Ligand-Target Predictions to Accelerated Drug Discovery

chemical genomics
openalex   +1 more source

Iridium-Catalyzed CH-Functionalization : Development and Applications of Innovative Strategies for Hydrogen Isotope Exchange on Small Molecules and Biotherapeutic Drugs for Drug Discovery

, 2020
Mégane Valero
openalex   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Recent Advances in Computer-Aided Drug Design and Drug Discovery. [PDF]

Molecules
Zhang JZH.
europepmc   +1 more source

Quantum Subspace Expansion: Revolutionizing Molecular Energy Calculations for Drug Discovery

quantum chemical science
openalex   +1 more source