Results 221 to 230 of about 568,926 (318)

Liver‐specific lncRNAs associated with liver cancers

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) are regulatory molecules with various functions. They are more tissue‐specific than proteins and can be used as potential biomarkers, particularly in cancer diagnostics and prognosis. In this review, we have systematically compiled all lncRNAs with exclusive expression in the human liver, verified their liver specificity ...
Olga Y. Burenina, Roman K. Makarchenko, Maria P. Rubtsova, Olga A. Dontsova   +3 more
wiley   +1 more source

In Silico Exploration of Natural Antioxidants for Sepsis Drug Discovery. [PDF]

Molecules
Andrés CMC, Munguira EB, Juan CA, Lobo F, Pérez-Lebeña E, Pérez de la Lastra JM.   +5 more
europepmc   +1 more source

Erratum: Genomics and proteomics: The new millenium of drug discovery and development

, 2001
Mary Jane Cunningham
openalex   +1 more source

NMR screening of low molecular weight inhibitors targeting the papain‐like protease (PLPro) of SARS‐CoV‐2

FEBS Open Bio, EarlyView.
Papain‐like protease from SARS‐CoV‐2 plays an important role in the cleavage of the viral polyproteins and in the suppression of the host's immune response. Here, we present the results of an NMR screening study. We identified 86 binding compounds, of which five candidates were chosen for in‐depth analysis.
Dennis J. Pyper, Sridhar Sreeramulu, Benjamin T. Lanham, Elizabeth M. Engle, David Fushman, Harald Schwalbe   +5 more
wiley   +1 more source

Drug Metabolism Studies in Discovery Stage using human materials

, 2001
Yoshinobu Yoshimura
openalex   +2 more sources

Ro 31‐8220 suppresses bladder cancer progression via enhancing autophagy in vitro and in vivo

FEBS Open Bio, EarlyView.
The pan‐protein kinase C inhibitor Ro‐31‐8220 demonstrates potent anti‐bladder cancer effects both in vitro and in vivo by suppressing migration/invasion, inducing apoptosis and crucially activating autophagy, where blocking autophagy with chloroquine reduces its cell‐killing efficacy, suggesting its promise as a novel therapeutic candidate requiring ...
Shengjun Fu, Yan Tao, Shan Wu, Yuwen Gong, Youli Zhao, Shaomin Niu, Hui Cheng, You Mu, Na Xu, Ying Wang, Jianzhong Lu, Shanhui Liu, Lanlan Li   +12 more
wiley   +1 more source

Artificial intelligence approaches for anti-addiction drug discovery.

Digit Discov
Chen D, Jiang J, Hayes N, Su Z, Wei GW.
europepmc   +1 more source

Enhancing schistosomiasis drug discovery approaches with optimized proteasome substrates. [PDF]

Protein Sci
Silva EB, Jiang Z, Liu C, Fajtová P, Teixeira TR, de Castro Fiorini Maia G, Liu LJ, El-Sakkary N, Skinner DE, Syed A, Wang SC, Caffrey CR, O'Donoghue AJ.   +12 more
europepmc   +1 more source

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

FEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr, Michael Fauler, Thomas Zimmer, Bettina Jungwirth, Hubert Schrezenmeier, David Alexander Christian Messerer   +5 more
wiley   +1 more source

Potential molecular targets for anti-obesity drugs. After the discovery of leptin.

, 2001
Shuji Hidaka, Yoshihiro Ogawa, Kazuwa Nakao   +2 more
openalex   +2 more sources