Results 221 to 230 of about 5,785,146 (400)

Evaluation and modification of tumor cell isolation techniques from malignant effusions for rapid drug sensitivity testing

Molecular Oncology, EarlyView.
Non‐small cell lung cancer targeted treatment is limited to a few known genetic alterations, with few alternatives in advanced treatment lines. To direct treatment decisions by drug sensitivity testing (DST), this study compared several methods for tumor cell isolation from malignant effusions, pointing to repeated CD45+ cell depletion for effective ...
Navit Mooshayef, Hana Barhom, Sumit Chatterji, Netta Hecht, Oran Warhaftig, Iris Kamer, Oranit Zadok, Jair Bar, Limor Broday, Amir Onn, Michael Peled   +10 more
wiley   +1 more source

A Perspective on the Strategic Application of Deconstruction-Reconstruction in Drug Discovery. [PDF]

J Med Chem
Blackwell JH, Michaelides IN, Gibault F.
europepmc   +1 more source

STAT proteins: novel molecular targets for cancer drug discovery

, 2000
James Turkson, Richard Jove
openalex   +1 more source

Impact of Genomics in Drug Discovery [PDF]

, 2001
Susan J. Ward
openalex   +1 more source

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

Molecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon, Moa Stenudd, Margherita Zamboni, Kanar Alkass, Carl‐Johan Eriksson, Lars Pedersen, Alrik Schörling, Anna Thoss, Anders Bergh, Pernilla Wikström, Hans‐Olov Adami, Henrik Toft Sørensen, Henrik Druid, Jonas Frisén   +13 more
wiley   +1 more source

Brain Organoids and Assembloids-From Disease Modeling to Drug Discovery. [PDF]

Cells
Ajongbolo AO, Langhans SA.
europepmc   +1 more source

Natural Product-Based Anti-HIV Drug Discovery and Development Facilitated by the NCI Developmental Therapeutics Program. [PDF]

, 2001
Stringner S. Yang, Gordon M. Cragg, David Newman, John P. Bader   +3 more
openalex   +1 more source

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source

Harnessing Noncanonical Proteins for Next-Generation Drug Discovery and Diagnosis. [PDF]

WIREs Mech Dis
Rajinikanth N, Chauhan R, Prabakaran S.
europepmc   +1 more source

Significance of the human genome sequence to drug discovery [PDF]

, 2001
Olivier Grenet
openalex   +1 more source