Results 221 to 230 of about 1,411,950 (341)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Special Issue "Role of Molecular Dynamics Simulations and Related Methods in Drug Discovery". [PDF]

Int J Mol Sci
Liu H.
europepmc   +1 more source

Structure of Class B GPCRs: new horizons for drug discovery [PDF]

, 2014
Andrea Bortolato, A.S. Dore, Kaspar Hollenstein, Benjamin G. Tehan, Jonathan S. Mason, Fiona H. Marshall   +5 more
openalex   +1 more source

Interplay between RNA‐protein interactions and RNA structures in gene regulation

FEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö   +2 more
wiley   +1 more source

The ABCs of psychedelics: a preclinical roadmap for drug discovery. [PDF]

Trends Pharmacol Sci
Kwan AC, Mantsch JR, McCorvy JD.
europepmc   +1 more source

Artificial Intelligence and Machine Learning Approaches for Target-Based Drug Discovery: A Focus on GPCR-Ligand Interactions

Martins Otun
openalex   +2 more sources

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source

REINFORCE-ING Chemical Language Models for Drug Discovery. [PDF]

J Chem Inf Model
Thomas M, Bou A, Gómez-Tamayo JC, Tresadern G, Ahmad M, De Fabritiis G.   +5 more
europepmc   +1 more source

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

Special Issue "Natural Products in Drug Discovery and Development". [PDF]

Int J Mol Sci
Gao TL.
europepmc   +1 more source