Results 231 to 240 of about 1,411,950 (341)

Abstract P-4: Cryo-Electron Microscopy of G-Protein Coupled Receptor Complexes for Drug Discovery Approaches

, 2019
Anastasiia Gusach, Aleksandra Luginina, Valentin Borshchevskiy, Alexey Mishin   +3 more
openalex   +1 more source

Long‐term culture of skin biopsies: maintenance of fibroblast production and competency of reprogramming

FEBS Open Bio, EarlyView.
Skin biopsies taken from a patient with an ultra‐rare disorder as well as controls were cultured for up to 473 days. The chunks of skin were serially transferred to a new culture plate when confluent with fibroblasts. Different generations of fibroblasts were analyzed for cell and molecular properties, proliferation, and competence for reprogramming to
Sudiksha Rathan‐Kumar, Michael A. Ripperger, Grant M. Westlake, Kevin C. Ess   +3 more
wiley   +1 more source

Faculty Opinions recommendation of Biased agonism: An emerging paradigm in GPCR drug discovery.

, 2017
Marcin Chwistek
openalex   +2 more sources

Drug Discovery [PDF]

, 1971
openaire   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

LIDDIA: Language-based Intelligent Drug Discovery Agent. [PDF]

Proc Conf Empir Methods Nat Lang Process
Averly R, Baker FN, Watson IA, Ning X.
europepmc   +1 more source

Discovery of Drug-like Inhibitors of the Human Caf1/CNOT7 poly(A)-Selective Nuclease Using Compound Screening [PDF]

Ishwinder Kaur, Lubna Hashmi, Peter M. Fischer, G. Sebastiaan Winkler   +3 more
openalex   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Recent advances in glycosome biogenesis and its implications for drug discovery [PDF]

Lisa Hohnen, Chethan K. Krishna, Lary C. Walker, Ralf Erdmann, Vishal C. Kalel   +4 more
openalex   +1 more source