Results 241 to 250 of about 1,359,668 (353)

Editorial: Tuberculosis: recent updates in basic research, drug discovery and treatment. [PDF]

Front Med (Lausanne)
Bendre AD, Singh P, Jaiswal S.
europepmc   +1 more source

High-Density Miniaturized Thermal Shift Assays as a General Strategy for Drug Discovery

, 2001
Michael W. Pantoliano, Eugene C. Petrella, Joseph D. Kwasnoski, Victor S. Lobanov, James C. Myslik, E. R. Graf, Ted Carver, Eric D. Asel, Barry A. Springer, Pamela Lane, F.R. Salemme   +10 more
openalex   +1 more source

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

FEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian, Khodakaram Jahanbin, Shekoofeh Nikooei, Marzieh Rostaminejad, Arezoo Rahimi, Pedram Abdizadeh, Behnam Alipoor   +6 more
wiley   +1 more source

Target Engagement Assays in Early Drug Discovery. [PDF]

J Med Chem
St John-Campbell S, Bhalay G.
europepmc   +1 more source

An efficient strategy for producing RNA‐free Nucleocapsid protein of SARS‐CoV‐2 for biochemical and structural investigations

FEBS Open Bio, EarlyView.
Cleavable N‐terminal Thioredoxin fusion enabled soluble expression and purification of otherwise insoluble SARS‐CoV‐2 Nucleocapsid (N) protein. A four‐step purification strategy yielded highly homogeneous, RNA‐free N protein. Binding assays showed high RNA affinity (Kd ~ 28 nm). The study will facilitate high‐resolution structural studies of N protein,
Shweta Singh, Gagan D. Gupta
wiley   +1 more source

Machine Learning for Multi-Target Drug Discovery: Challenges and Opportunities in Systems Pharmacology. [PDF]

Pharmaceutics
Bi X, Wang Y, Wang J, Liu C.
europepmc   +1 more source

Preparation and characterization of renal cell peptides from fetal rats for their antitumor activity

FEBS Open Bio, EarlyView.
This study aimed to prepare renal cells (RCs) from fetal rats which were digested by enzymes. Candidate peptides RCPs were characterized by capillary HPLC and MS and their bioactivity was predicted using peptideranker. The predicted top 10 bioactive peptides were synthesized.
Zhe Zhang, Yuan Cao, Jing Du, Ying Zhang, Junxia Wang, Ying Yuan, Lianqing Sun   +6 more
wiley   +1 more source

Molecular Paleontology Meets Drug Discovery: The Case for De-extinct Antimicrobials. [PDF]

ACS Omega
Tenchov R, Zhou QA.
europepmc   +1 more source

Use of Genomics in Drug Discovery: Application to Target Identification, High-Throughput Screening and Diagnosis

, 2001
Hisafumi Yamada‐Okabe
openalex   +2 more sources

Phenotypic plasticity in a novel set of EGFR tyrosine kinase inhibitor‐adapted non‐small cell lung cancer cell lines

FEBS Open Bio, EarlyView.
Phenotypic plasticity in a newly established set of EGFR inhibitor‐adapted NSCLC cell lines during adaptation and in established cell lines. Here, we introduce novel sublines of the EGFR‐mutant non‐small cell lung cancer (NSCLC) cell lines HCC827 and HCC4006 adapted to the EGFR kinase inhibitors gefitinib (HCC827rGEFI2μm, HCC4006rGEFI1μm), erlotinib ...
Tharsagini V. Nanthaprakash, Campbell W. Gourlay, Ina Oehme, Michelle D. Garrett, Jindrich Cinatl Jr, Mark N. Wass, Martin Michaelis   +6 more
wiley   +1 more source