Results 271 to 280 of about 3,678,790 (312)
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Phosphoproteomics in drug discovery
Drug Discovery Today, 2014Several important aspects of the drug discovery process, including target identification, mechanism of action determination and biomarker identification as well as drug repositioning, require complete understanding of the effects of drugs on protein phosphorylation in relevant biological systems.
Melody K. Morris +3 more
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Microdialysis in Drug Discovery
Current Drug Discovery Technologies, 2004Microdialysis has been developed during the last 25 years by several authors primarily to study brain function and changes in levels of endogenous compounds such as neurotransmitters or metabolites. The development of microdialysis for the purpose of measuring drugs was initiated during the late eighties.
Christian, Höcht +2 more
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Drug Discovery Today, 2003
In the past two decades, the identification of commonly mutated oncogenes and tumour suppressor genes has driven an unprecedented growth in our understanding of the genetic basis of human cancer. Although oncogenes can clearly serve as classically defined drug targets whose inactivation by small molecules could place a brake on cancer cell ...
David P, Lane, Ted R, Hupp
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In the past two decades, the identification of commonly mutated oncogenes and tumour suppressor genes has driven an unprecedented growth in our understanding of the genetic basis of human cancer. Although oncogenes can clearly serve as classically defined drug targets whose inactivation by small molecules could place a brake on cancer cell ...
David P, Lane, Ted R, Hupp
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Drug Discovery Today, 1999
The promise of genomics has dramatically altered the way drug discovery is now viewed. Overshadowed by the exuberance for genomics are the observations that most disease processes and treatments are manifest at the protein level and that there may not be a good correlation between gene expression and protein expression. An alternative and complementary
, Wang, , Hewick
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The promise of genomics has dramatically altered the way drug discovery is now viewed. Overshadowed by the exuberance for genomics are the observations that most disease processes and treatments are manifest at the protein level and that there may not be a good correlation between gene expression and protein expression. An alternative and complementary
, Wang, , Hewick
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Expert Opinion on Drug Discovery, 2007
Ayurveda is a major traditional system of Indian medicine that is still being successfully used in many countries. Recapitulation and adaptation of the older science to modern drug discovery processes can bring renewed interest to the pharmaceutical world and offer unique therapeutic solutions for a wide range of human disorders. Eventhough time-tested
Premalatha, Balachandran +1 more
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Ayurveda is a major traditional system of Indian medicine that is still being successfully used in many countries. Recapitulation and adaptation of the older science to modern drug discovery processes can bring renewed interest to the pharmaceutical world and offer unique therapeutic solutions for a wide range of human disorders. Eventhough time-tested
Premalatha, Balachandran +1 more
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The Dynamics of Drug Discovery
Current Topics in Medicinal Chemistry, 2015Proteins are not static objects. To carry out their functions in the cells and participate in biochemical interaction networks, proteins have to explore different conformational substates, which favor the adaptation to different partners and ultimately allow them to respond to changes in the environment.
Moroni Elisabetta +2 more
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Nature Reviews Drug Discovery, 2002
NMR spectroscopy has evolved into an important technique in support of structure-based drug design. Here, we survey the principles that enable NMR to provide information on the nature of molecular interactions and, on this basis, we discuss current NMR-based strategies that can identify weak-binding compounds and aid their development into potent, drug-
Maurizio, Pellecchia +2 more
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NMR spectroscopy has evolved into an important technique in support of structure-based drug design. Here, we survey the principles that enable NMR to provide information on the nature of molecular interactions and, on this basis, we discuss current NMR-based strategies that can identify weak-binding compounds and aid their development into potent, drug-
Maurizio, Pellecchia +2 more
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Pharmacokinetics in Drug Discovery
Journal of Pharmaceutical Sciences, 2008The aim of this current review is to summarize the present status of pharmacokinetics in Drug Discovery. The review is structured into four sections. The first section is a general overview of what we understand by pharmacokinetics and the different LADMET aspects: Liberation, Absorption, Distribution, Metabolism, Excretion, and Toxicity.
Ana, Ruiz-Garcia +3 more
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2014
Abstract The opportunity to see the fruit of scientific work in one’s own lifetime proved a compelling motivation to leave a productive academic career in biochemistry and join the pharmaceutical industry, the Merck Research Laboratories specifically.
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Abstract The opportunity to see the fruit of scientific work in one’s own lifetime proved a compelling motivation to leave a productive academic career in biochemistry and join the pharmaceutical industry, the Merck Research Laboratories specifically.
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2003
The pharmaceutical industry is no longer the “analysts’ darling” — quite the reverse is true. The industry is currently facing increasing pressure due to the lack of innovateon and productivity in drug research and development (Fig. 1, global R&D productivity trend 1991–2001).
J, Reinhard-Rupp, G, Wess
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The pharmaceutical industry is no longer the “analysts’ darling” — quite the reverse is true. The industry is currently facing increasing pressure due to the lack of innovateon and productivity in drug research and development (Fig. 1, global R&D productivity trend 1991–2001).
J, Reinhard-Rupp, G, Wess
openaire +2 more sources