Results 271 to 280 of about 6,006,073 (362)

Rethinking Nature's Pharmacy: AI Era and Natural Product Drug Discovery. [PDF]

Pharmaceuticals (Basel)
Paerhati Y, Aikebaier A, Dilimulati D, Baishan A, Yusufujiang N, Qiu X, Wusiman Y, Zhou W.   +7 more
europepmc   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Computational approaches for flavivirus drug discovery: targeting structural and non-structural proteins. [PDF]

RSC Med Chem
Al-Nema M, Rendeiro MM, Liao D, Maki MAA.   +3 more
europepmc   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Early-stage drug discovery in a new-generation ultrahigh-throughput mass spectrometry platform. [PDF]

Proc Natl Acad Sci U S A
Morato NM, Feng Y, Chen K, Huang KH, Owen A, Caruso JV, Yang B, Kulathunga SC, Mesecar AD, Klumpp-Thomas C, Radujevic A, Godfrey AG, Gardner S, Rudnicki DD, Galbraith M, Gloeckner A, Hajdu C, Pringle SD, Morris M, Balog J, Cooks RG.   +20 more
europepmc   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Recent advances towards BACE1 drug discovery and therapeutics design. [PDF]

RSC Med Chem
Imran S, Patel M, Noroozifar M, Kerman K.   +3 more
europepmc   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

AI-Driven Drug Discovery: Focus on Targets for Solid Tumors. [PDF]

Pharmaceutics
Wu J, He J, Ni Q, Li Z, Lin X, Zhao Z, Qiu L, Wang H, Li S, Shi C, Zhang Y, Gao H, Lu J.   +12 more
europepmc   +1 more source