Results 271 to 280 of about 658,841 (317)
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Drug News & Perspectives, 2005
New brief reports this month include: Strategies for Duchenne Muscular Dystrophy: Various approaches are being explored to abate the dystrophic process including cellular therapies (transplanting stem cells or myogenic precursors into muscles), molecular approaches (delivering a functional or correcting the mutant dystrophin gene), such as MyoDys ...
V K, Khurdayan, J, Bozzo, J R, Prous
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New brief reports this month include: Strategies for Duchenne Muscular Dystrophy: Various approaches are being explored to abate the dystrophic process including cellular therapies (transplanting stem cells or myogenic precursors into muscles), molecular approaches (delivering a functional or correcting the mutant dystrophin gene), such as MyoDys ...
V K, Khurdayan, J, Bozzo, J R, Prous
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Current Opinion in Chemical Biology, 2002
Drug discovery is a prolonged process that uses a variety of tools from diverse fields. To accelerate the process, a number of biotechnologies, including genomics, proteomics and a number of cellular and organismic methodologies, have been developed. Proteomics development faces interdisciplinary challenges, including both the traditional (biology and ...
Jonathan, Burbaum, Gabriela M, Tobal
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Drug discovery is a prolonged process that uses a variety of tools from diverse fields. To accelerate the process, a number of biotechnologies, including genomics, proteomics and a number of cellular and organismic methodologies, have been developed. Proteomics development faces interdisciplinary challenges, including both the traditional (biology and ...
Jonathan, Burbaum, Gabriela M, Tobal
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Causality Discovery with Domain Knowledge for Drug-Drug Interactions Discovery
2019Bayesian Network Probabilistic Graphs have recently been applied to the problem of discovery drug-drug interactions, i.e., the identification of drugs that, when consumed together, produce an unwanted side effect. These methods have the advantage of being explainable: the cause of the interaction is made explicit.
Sitthichoke Subpaiboonkit +4 more
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1988
The role of the pharmaceutical industry has been defined as the application of “basic knowledge in biology and chemistry to the discovery of new medicines” [1]. While it is generally acknowledged that the industry has made significant contributions to the health and financial well-being of society in this role [2], there is, by and large, no single ...
M, Williams, G L, Neil
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The role of the pharmaceutical industry has been defined as the application of “basic knowledge in biology and chemistry to the discovery of new medicines” [1]. While it is generally acknowledged that the industry has made significant contributions to the health and financial well-being of society in this role [2], there is, by and large, no single ...
M, Williams, G L, Neil
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Current Topics in Medicinal Chemistry, 2003
In recent years, tools for the development of new drugs have been dramatically improved. These include genomic and proteomic research, numerous biophysical methods, combinatorial chemistry and screening technologies. In addition, early ADMET studies are employed in order to significantly reduce the failure rate in the development of drug candidates. As
Schwardt O, Kolb H, Ernst B
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In recent years, tools for the development of new drugs have been dramatically improved. These include genomic and proteomic research, numerous biophysical methods, combinatorial chemistry and screening technologies. In addition, early ADMET studies are employed in order to significantly reduce the failure rate in the development of drug candidates. As
Schwardt O, Kolb H, Ernst B
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Trends in Genetics, 2021
Drug discovery is a complex process with high attrition rate: only about half of the compounds in advanced preclinical stages actually enter human trials. Key to these failures is our lack of understanding of human biology and the difficulties in translating our preclinical knowledge into cures.
Alexis Hubaud, Ajeet Pratap Singh
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Drug discovery is a complex process with high attrition rate: only about half of the compounds in advanced preclinical stages actually enter human trials. Key to these failures is our lack of understanding of human biology and the difficulties in translating our preclinical knowledge into cures.
Alexis Hubaud, Ajeet Pratap Singh
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Proceedings of the Royal College of Physicians of Edinburgh, 1995
A review of the discovery of ...
Bowman, W C, Harvey, A L
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A review of the discovery of ...
Bowman, W C, Harvey, A L
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Phosphoproteomics in drug discovery
Drug Discovery Today, 2014Several important aspects of the drug discovery process, including target identification, mechanism of action determination and biomarker identification as well as drug repositioning, require complete understanding of the effects of drugs on protein phosphorylation in relevant biological systems.
Melody K. Morris +3 more
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Bioinformatics and drug discovery
Current Opinion in Biotechnology, 1994Bioinformatics involves both the automatic processing of large amounts of existing data and the creation of new types of information resource. Both will be required if the data are to be transformed into information and used to help in the discovery of drugs.
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Microdialysis in Drug Discovery
Current Drug Discovery Technologies, 2004Microdialysis has been developed during the last 25 years by several authors primarily to study brain function and changes in levels of endogenous compounds such as neurotransmitters or metabolites. The development of microdialysis for the purpose of measuring drugs was initiated during the late eighties.
Christian, Höcht +2 more
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