Results 281 to 290 of about 658,841 (317)
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Drug Discovery Today, 2003
In the past two decades, the identification of commonly mutated oncogenes and tumour suppressor genes has driven an unprecedented growth in our understanding of the genetic basis of human cancer. Although oncogenes can clearly serve as classically defined drug targets whose inactivation by small molecules could place a brake on cancer cell ...
David P, Lane, Ted R, Hupp
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In the past two decades, the identification of commonly mutated oncogenes and tumour suppressor genes has driven an unprecedented growth in our understanding of the genetic basis of human cancer. Although oncogenes can clearly serve as classically defined drug targets whose inactivation by small molecules could place a brake on cancer cell ...
David P, Lane, Ted R, Hupp
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Drug Discovery Today, 1999
The promise of genomics has dramatically altered the way drug discovery is now viewed. Overshadowed by the exuberance for genomics are the observations that most disease processes and treatments are manifest at the protein level and that there may not be a good correlation between gene expression and protein expression. An alternative and complementary
, Wang, , Hewick
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The promise of genomics has dramatically altered the way drug discovery is now viewed. Overshadowed by the exuberance for genomics are the observations that most disease processes and treatments are manifest at the protein level and that there may not be a good correlation between gene expression and protein expression. An alternative and complementary
, Wang, , Hewick
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Expert Opinion on Drug Discovery, 2007
Ayurveda is a major traditional system of Indian medicine that is still being successfully used in many countries. Recapitulation and adaptation of the older science to modern drug discovery processes can bring renewed interest to the pharmaceutical world and offer unique therapeutic solutions for a wide range of human disorders. Eventhough time-tested
Premalatha, Balachandran +1 more
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Ayurveda is a major traditional system of Indian medicine that is still being successfully used in many countries. Recapitulation and adaptation of the older science to modern drug discovery processes can bring renewed interest to the pharmaceutical world and offer unique therapeutic solutions for a wide range of human disorders. Eventhough time-tested
Premalatha, Balachandran +1 more
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Nature Reviews Drug Discovery, 2012 The Dynamics of Drug Discovery
Current Topics in Medicinal Chemistry, 2015Proteins are not static objects. To carry out their functions in the cells and participate in biochemical interaction networks, proteins have to explore different conformational substates, which favor the adaptation to different partners and ultimately allow them to respond to changes in the environment.
Moroni Elisabetta +2 more
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2014
Abstract The opportunity to see the fruit of scientific work in one’s own lifetime proved a compelling motivation to leave a productive academic career in biochemistry and join the pharmaceutical industry, the Merck Research Laboratories specifically.
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Abstract The opportunity to see the fruit of scientific work in one’s own lifetime proved a compelling motivation to leave a productive academic career in biochemistry and join the pharmaceutical industry, the Merck Research Laboratories specifically.
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2003
Publisher Summary This chapter describes proteomics technology and discusses the technical problems associated with proteome analysis along with ways to overcome the respective problems. It includes a representative selection of examples of the application of proteomics studies to the identification of markers and new drug targets.
Rodney M, Hewick +2 more
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Publisher Summary This chapter describes proteomics technology and discusses the technical problems associated with proteome analysis along with ways to overcome the respective problems. It includes a representative selection of examples of the application of proteomics studies to the identification of markers and new drug targets.
Rodney M, Hewick +2 more
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New England Journal of Medicine, 1964
THE history of early drug discovery is essentially that of a random search for therapeutic agents from plants, animals and naturally occurring minerals.
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THE history of early drug discovery is essentially that of a random search for therapeutic agents from plants, animals and naturally occurring minerals.
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Anti-trypanosomatid drug discovery: progress and challenges
Nature Reviews Microbiology, 2022Manu De Rycker +2 more
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