Results 311 to 320 of about 5,239,733 (368)
Some of the next articles are maybe not open access.
Microdialysis in Drug Discovery
Current Drug Discovery Technologies, 2004Microdialysis has been developed during the last 25 years by several authors primarily to study brain function and changes in levels of endogenous compounds such as neurotransmitters or metabolites. The development of microdialysis for the purpose of measuring drugs was initiated during the late eighties.
Christian, Höcht +2 more
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Drug Discovery Today, 2003
In the past two decades, the identification of commonly mutated oncogenes and tumour suppressor genes has driven an unprecedented growth in our understanding of the genetic basis of human cancer. Although oncogenes can clearly serve as classically defined drug targets whose inactivation by small molecules could place a brake on cancer cell ...
David P, Lane, Ted R, Hupp
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In the past two decades, the identification of commonly mutated oncogenes and tumour suppressor genes has driven an unprecedented growth in our understanding of the genetic basis of human cancer. Although oncogenes can clearly serve as classically defined drug targets whose inactivation by small molecules could place a brake on cancer cell ...
David P, Lane, Ted R, Hupp
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Drug Discovery Today, 1999
The promise of genomics has dramatically altered the way drug discovery is now viewed. Overshadowed by the exuberance for genomics are the observations that most disease processes and treatments are manifest at the protein level and that there may not be a good correlation between gene expression and protein expression. An alternative and complementary
, Wang, , Hewick
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The promise of genomics has dramatically altered the way drug discovery is now viewed. Overshadowed by the exuberance for genomics are the observations that most disease processes and treatments are manifest at the protein level and that there may not be a good correlation between gene expression and protein expression. An alternative and complementary
, Wang, , Hewick
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Molecular hybridization: a powerful tool for multitarget drug discovery
Expert Opinion on Drug DiscoveryIntroduction The current drug discovery paradigm of ‘one drug, multiple targets’ has gained attention from both the academic medicinal chemistry community and the pharmaceutical industry.
Pedro de Sena Murteira Pinheiro +3 more
semanticscholar +1 more source
Molecular Docking: Principles, Advances, and its Applications in Drug Discovery
Letters in Drug Design & Discovery, 2022Molecular docking is a structure-based computational method that generates the binding pose and affinity between ligands and targets. There are many powerful docking programs. However, there is no single program that is suitable for every system. Hence,
M. T. Muhammed, Esin Aki-Yalcin
semanticscholar +1 more source
Nature Reviews Drug Discovery, 2002
NMR spectroscopy has evolved into an important technique in support of structure-based drug design. Here, we survey the principles that enable NMR to provide information on the nature of molecular interactions and, on this basis, we discuss current NMR-based strategies that can identify weak-binding compounds and aid their development into potent, drug-
Maurizio, Pellecchia +2 more
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NMR spectroscopy has evolved into an important technique in support of structure-based drug design. Here, we survey the principles that enable NMR to provide information on the nature of molecular interactions and, on this basis, we discuss current NMR-based strategies that can identify weak-binding compounds and aid their development into potent, drug-
Maurizio, Pellecchia +2 more
openaire +2 more sources
Journal of Medicinal Chemistry, 2020
Hunting for chemicals with favourable pharmacological, toxicological and pharmacokinetic properties remains a formidable challenge for drug discovery. Deep learning provides us with powerful tools to build predictive models that are appropriate for the ...
Zhaoping Xiong +10 more
semanticscholar +1 more source
Hunting for chemicals with favourable pharmacological, toxicological and pharmacokinetic properties remains a formidable challenge for drug discovery. Deep learning provides us with powerful tools to build predictive models that are appropriate for the ...
Zhaoping Xiong +10 more
semanticscholar +1 more source
Natural products: A lead for drug discovery and development
Phytotherapy Research, 2021Natural products are used since ancient times in folklore for the treatment of various ailments. Plant‐derived products have been recognized for many years as a source of therapeutic agents and structural diversity.
B. Chopra, A. Dhingra
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The New Era of Drug Discovery: The Power of Computer-aided Drug Design (CADD)
Letters in Drug Design & Discovery, 2022Drug design and discovery is a process that requires high financial cost, as time-consuming. For many years, this process was focused on empirical pharmacology.
I. Nascimento +2 more
semanticscholar +1 more source
2003
The pharmaceutical industry is no longer the “analysts’ darling” — quite the reverse is true. The industry is currently facing increasing pressure due to the lack of innovateon and productivity in drug research and development (Fig. 1, global R&D productivity trend 1991–2001).
J, Reinhard-Rupp, G, Wess
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The pharmaceutical industry is no longer the “analysts’ darling” — quite the reverse is true. The industry is currently facing increasing pressure due to the lack of innovateon and productivity in drug research and development (Fig. 1, global R&D productivity trend 1991–2001).
J, Reinhard-Rupp, G, Wess
openaire +2 more sources