Results 321 to 330 of about 5,239,733 (368)

Pharmacokinetics in Drug Discovery

Journal of Pharmaceutical Sciences, 2008
The aim of this current review is to summarize the present status of pharmacokinetics in Drug Discovery. The review is structured into four sections. The first section is a general overview of what we understand by pharmacokinetics and the different LADMET aspects: Liberation, Absorption, Distribution, Metabolism, Excretion, and Toxicity.
Ana, Ruiz-Garcia, Marival, Bermejo, Aaron, Moss, Vicente G, Casabo   +3 more
openaire   +2 more sources

Bioinformatics and drug discovery

Current Opinion in Biotechnology, 1994
Bioinformatics involves both the automatic processing of large amounts of existing data and the creation of new types of information resource. Both will be required if the data are to be transformed into information and used to help in the discovery of drugs.
openaire   +2 more sources

Yeast and drug discovery

Functional & Integrative Genomics, 2002
Advanced genetic techniques, along with the high degree of conservation of basic cellular processes, have made the yeast Saccharomyces cerevisiae a valuable system for identification of new drug targets, target-based and non-target-based drug screening, and detailed analysis of the cellular effects of drugs.
openaire   +2 more sources

Artificial intelligence for natural product drug discovery

Nature reviews. Drug discovery, 2023
Michael W. Mullowney, Katherine R. Duncan, S. Elsayed, Neha Garg, J. V. D. van der Hooft, N. Martin, David Meijer, Barbara R. Terlouw, Friederike Biermann, K. Blin, J. Durairaj, M. Gorostiola González, Eric J. N. Helfrich, Florian Huber, S. Leopold-Messer, Kohulan Rajan, Tristan de Rond, Jeffrey A. van Santen, Maria Sorokina, Marcy J. Balunas, M. Beniddir, Doris A. van Bergeijk, L. Carroll, Chase M. Clark, Djork-Arné Clevert, C. Dejong, Chao Du, Scarlet Ferrinho, Francesca Grisoni, Albert Hofstetter, W. Jespers, Olga V. Kalinina, S. Kautsar, Hyunwoo Kim, Tiago F. Leão, J. Masschelein, Evan R Rees, R. Reher, Daniel Reker, Philippe Schwaller, Marwin H. S. Segler, M. Skinnider, Allison S. Walker, E. Willighagen, B. Zdrazil, N. Ziemert, R. Goss, Pierre Guyomard, Andrea Volkamer, W. Gerwick, Hyun Uk Kim, Rolf Müller, G. V. van Wezel, G. V. van Westen, A. Hirsch, Roger G. Linington, Serina L. Robinson, M. Medema   +57 more
semanticscholar   +1 more source

Integrating QSAR modelling and deep learning in drug discovery: the emergence of deep QSAR

Nature reviews. Drug discovery, 2023
A. Tropsha, O. Isayev, Alexandre Varnek, Gisbert Schneider, Artem Cherkasov   +4 more
semanticscholar   +1 more source

Drug discovery in academia

American Journal of Physiology-Cell Physiology, 2004
Drug discovery and development is generally done in the commercial rather than the academic realm. Drug discovery involves target discovery and validation, lead identification by high-throughput screening, and lead optimization by medicinal chemistry.
openaire   +2 more sources

Lipidomics in drug discovery

Drug Discovery Today, 2014
Lipidomics is a rapidly growing technology that can be used in biomedical research to study disease mechanisms, identify novel disease biomarkers and drug efficacy biomarkers, and reveal off-target effects. Lipidomics can also be used to elucidate the mechanism of action of different drug compounds or as readouts in Mendelian randomization approaches ...
Terhi, Vihervaara, Matti, Suoniemi, Reijo, Laaksonen   +2 more
openaire   +2 more sources

Lipophilicity in drug discovery

Expert Opinion on Drug Discovery, 2010
The role of lipophilicity in determining the overall quality of candidate drug molecules is of paramount importance. Recent developments suggest that, as well as determining pre-clinical ADMET (absorption, distribution, metabolism, elimination and toxicology) properties, compounds of optimal lipophilicity might have increased chances of success in ...
openaire   +3 more sources

XAI in Drug Discovery

[No abstract available]
openaire   +2 more sources

Trends in peptide drug discovery

Nature reviews. Drug discovery, 2021
Markus Muttenthaler, G. King, D. Adams, P. Alewood   +3 more
semanticscholar   +1 more source