Results 351 to 360 of about 5,785,146 (400)
Some of the next articles are maybe not open access.
Natural products: A lead for drug discovery and development
Phytotherapy Research, 2021Natural products are used since ancient times in folklore for the treatment of various ailments. Plant‐derived products have been recognized for many years as a source of therapeutic agents and structural diversity.
B. Chopra, A. Dhingra
semanticscholar +1 more source
1988
The role of the pharmaceutical industry has been defined as the application of “basic knowledge in biology and chemistry to the discovery of new medicines” [1]. While it is generally acknowledged that the industry has made significant contributions to the health and financial well-being of society in this role [2], there is, by and large, no single ...
Gary L. Neil, Michael Williams
openaire +3 more sources
The role of the pharmaceutical industry has been defined as the application of “basic knowledge in biology and chemistry to the discovery of new medicines” [1]. While it is generally acknowledged that the industry has made significant contributions to the health and financial well-being of society in this role [2], there is, by and large, no single ...
Gary L. Neil, Michael Williams
openaire +3 more sources
Expert Opinion on Drug Discovery, 2007
Ayurveda is a major traditional system of Indian medicine that is still being successfully used in many countries. Recapitulation and adaptation of the older science to modern drug discovery processes can bring renewed interest to the pharmaceutical world and offer unique therapeutic solutions for a wide range of human disorders. Eventhough time-tested
Rajgopal Govindarajan +1 more
openaire +3 more sources
Ayurveda is a major traditional system of Indian medicine that is still being successfully used in many countries. Recapitulation and adaptation of the older science to modern drug discovery processes can bring renewed interest to the pharmaceutical world and offer unique therapeutic solutions for a wide range of human disorders. Eventhough time-tested
Rajgopal Govindarajan +1 more
openaire +3 more sources
Nature Reviews Drug Discovery, 2002
NMR spectroscopy has evolved into an important technique in support of structure-based drug design. Here, we survey the principles that enable NMR to provide information on the nature of molecular interactions and, on this basis, we discuss current NMR-based strategies that can identify weak-binding compounds and aid their development into potent, drug-
Maurizio Pellecchia +3 more
openaire +3 more sources
NMR spectroscopy has evolved into an important technique in support of structure-based drug design. Here, we survey the principles that enable NMR to provide information on the nature of molecular interactions and, on this basis, we discuss current NMR-based strategies that can identify weak-binding compounds and aid their development into potent, drug-
Maurizio Pellecchia +3 more
openaire +3 more sources
Microdialysis in Drug Discovery
Current Drug Discovery Technologies, 2004Microdialysis has been developed during the last 25 years by several authors primarily to study brain function and changes in levels of endogenous compounds such as neurotransmitters or metabolites. The development of microdialysis for the purpose of measuring drugs was initiated during the late eighties.
Javier A.W. Opezzo +2 more
openaire +3 more sources
Drug Discovery Today, 1999
The promise of genomics has dramatically altered the way drug discovery is now viewed. Overshadowed by the exuberance for genomics are the observations that most disease processes and treatments are manifest at the protein level and that there may not be a good correlation between gene expression and protein expression. An alternative and complementary
Jack H. Wang, Rodney M. Hewick
openaire +3 more sources
The promise of genomics has dramatically altered the way drug discovery is now viewed. Overshadowed by the exuberance for genomics are the observations that most disease processes and treatments are manifest at the protein level and that there may not be a good correlation between gene expression and protein expression. An alternative and complementary
Jack H. Wang, Rodney M. Hewick
openaire +3 more sources
Drug Discovery Today, 2003
In the past two decades, the identification of commonly mutated oncogenes and tumour suppressor genes has driven an unprecedented growth in our understanding of the genetic basis of human cancer. Although oncogenes can clearly serve as classically defined drug targets whose inactivation by small molecules could place a brake on cancer cell ...
Ted R. Hupp, David P. Lane
openaire +2 more sources
In the past two decades, the identification of commonly mutated oncogenes and tumour suppressor genes has driven an unprecedented growth in our understanding of the genetic basis of human cancer. Although oncogenes can clearly serve as classically defined drug targets whose inactivation by small molecules could place a brake on cancer cell ...
Ted R. Hupp, David P. Lane
openaire +2 more sources
Artificial intelligence for natural product drug discovery
Nature reviews. Drug discovery, 2023Michael W. Mullowney +57 more
semanticscholar +1 more source
Drug Discovery and Development
2016International ...
Lézé, Samuel, Sidi-Boumedine, Farid
openaire +1 more source
Chemogenomics in Drug Discovery
2006Chemogenomics is a new strategy in drug discovery which, in principle, searches for all molecules that are capable of interacting with any biological target. Because of the almost infinite number of drug-like organic molecules, this is an impossible task.
openaire +3 more sources