Results 141 to 150 of about 2,398,742 (264)

Rate-dependent drug effects: History and contemporary implications. [PDF]

J Pharmacol Exp Ther
Katz JL.
europepmc   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Computational modelling for improved translation of cardiac inotropic and lusitropic drug effects from rats to humans. [PDF]

J Pharmacol Toxicol Methods
Jung A, Augustin CM, Voglhuber-Höller J, Kiessling M, Ljubojevic-Holzer S, Mirams GR, Niederer SA, Plank G.   +7 more
europepmc   +1 more source

Climbing behavior by mice as an endpoint for preclinical assessment of drug effects in the absence and presence of pain. [PDF]

Front Pain Res (Lausanne), 2023
Santos EJ, Giddings AN, Kandil FA, Negus SS.   +3 more
europepmc   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Integrating drug effects on individual cardiac ionic currents and cardiac action potentials to understand nonclinical translation to clinical ECG changes. [PDF]

Front Pharmacol
Johannesen L, Abi-Gerges N, Sweat K, Roup A, Page G, Baron CA, Yu H, Wu WW.   +7 more
europepmc   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

A computational workflow for assessing drug effects on temporal signaling dynamics reveals robustness in stimulus-specific NFκB signaling. [PDF]

PLoS Comput Biol
Bozich ER, Guo X, Wilson JL, Hoffmann A.
europepmc   +1 more source

Adverse drug effects as a deterrent against willingness to use in the future among nightclub/festival attendees. [PDF]

Drug Alcohol Rev, 2023
Palamar JJ.
europepmc   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source