Results 101 to 110 of about 55,594 (335)

A phase I dose-escalation study of TAK-733, an investigational oral MEK inhibitor, in patients with advanced solid tumors. [PDF]

open access: yes, 2016
Purpose TAK-733, an investigational, selective, allosteric MEK1/2 inhibitor, has demonstrated antitumor effects against multiple cancer cell lines and xenograft models. This first-in-human study investigated TAK-733 in patients with solid tumors. Methods
Adjei, Alex A   +11 more
core   +1 more source

Drug Reaction with eosinophilia and systemic symptoms with alopecia universalis and vitiligo

open access: yesMedicina, 2021
Drug reactions with eosinophilia and systemic symptoms (DRESS) are rare and potentially fatal adverse hypersensitivity reaction to some drugs, especially anticonvulsants. The syndrome affects not only the skin but also other organs, especially the liver.
Ives Alexandre Yutani Koseki   +5 more
doaj  

Treatment Satisfaction, Efficacy, and Safety of Delgocitinib Ointment Following Switch From Topical Corticosteroids for Trunk and Extremity Rash in Atopic Dermatitis

open access: yesThe Journal of Dermatology, EarlyView.
ABSTRACT Atopic dermatitis (AD) is a chronic inflammatory disease characterized by recurrent remissions and relapses. Topical anti‐inflammatory steroids are commonly used for treatment, but their long‐term use poses concerns because of potential side effects. Delgocitinib ointment, a Janus kinase inhibitor, has demonstrated efficacy in several clinical
Masatoshi Abe   +5 more
wiley   +1 more source

Drug-induced hypersensitivity syndrome by liposomal amphotericin-B: a case report [PDF]

open access: yes, 2015
BACKGROUND: Liposomal amphotericin-B (Ambisome(®)) is widely used antifungal drug for treatments of invasive fungal infections. The use of liposomal amphotericin-B is increasing in medical setting because of its tolerability and potent antifungal ...
Hideo Kato   +7 more
core   +1 more source

The thymus and activation-regulated chemokine (TARC) level in serum at an early stage of a drug eruption is a prognostic biomarker of severity of systemic inflammation

open access: yesAllergology International, 2018
Background: In severe drug eruptions, precise evaluation of disease severity at an early stage is needed to start appropriate treatment. It is not always easy to diagnose these conditions at their early stage.
Takayoshi Komatsu-Fujii   +7 more
doaj   +1 more source

Barriers to Accurate Diagnosis of Infantile Atopic Dermatitis: Insights From a Survey of Pediatricians

open access: yesThe Journal of Dermatology, EarlyView.
ABSTRACT Accurate diagnosis is essential for timely intervention in atopic dermatitis (AD), yet delays in diagnosis remain common. To better understand current clinical practices regarding infantile AD, a questionnaire survey was conducted among Japanese pediatricians working at medical institutions with 19 or fewer beds.
Kiwako Yamamoto‐Hanada   +6 more
wiley   +1 more source

Testosterone Pellet–Induced Generalized Drug Eruption [PDF]

open access: bronze, 2020
Ryan C. Kelm   +3 more
openalex   +1 more source

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