scRNA‐Seq reveals anti‐lymphoma immune responses in mogamulizumab‐associated skin eruptions
CCR4 was expressed in malignant clones and regulatory T cells in untreated CTCL, that were decreased in MAR. Malignant clones in MAR showed a silenced phenotype with decreases in central memory markers SELL and CCR7, and GTP‐binding member GIMAP7 and upregulation of MMP2 inhibitor TIMP2 and tumour suppressor gene RUNX3.
Shannon Meledathu +13 more
wiley +1 more source
Efficacy and safety of brodalumab in palmoplantar pustulosis: A 68‐week randomized Phase 3 trial
This open‐label study is a continuation of the 16‐week double‐blind, Phase 3 trial assessing the efficacy and safety of brodalumab 210 mg subcutaneously, till a 68‐week extension period. Continued improvement was seen in the PPPASI 50/75/90 responses, PPPSI scores, PGA 0/1 responses and DLQI. Abstract Background The efficacy and safety of brodalumab in
Masamoto Murakami +6 more
wiley +1 more source
The Australasian Registry for Severe Cutaneous Adverse Reactions (AUS-SCAR) - Providing a roadmap for closing the diagnostic, patient, and healthcare gaps for a group of rare drug eruptions. [PDF]
James F +54 more
europepmc +1 more source
Dermatology 2.0: Precision medicine for inflammatory skin diseases
Digital immune mapping of transcriptomics profiles from inflammatory skin disease biopsies enables precise molecular diagnosis, quantification of immune modules and personalized therapy selection by matching dominant immune signatures to targeted treatments.
Jeremy Di Domizio +4 more
wiley +1 more source
Inflammatory dermatoses, infections, and drug eruptions are the most common skin conditions in hospitalized cancer patients. [PDF]
Phillips GS +11 more
europepmc +1 more source
Cell Therapy for Periodontal, Soft‐Tissue, and Craniofacial Regeneration
The clinical translation of mesenchymal stem/stromal cells (MSCs) represents a major advancement in dentistry, especially for periodontal, soft‐tissue, and craniofacial regeneration. However, several challenges remain to be addressed, including the absence of standardised protocols, limited scalability, regulatory hurdles, a lack of well‐controlled ...
Kamal Mustafa +5 more
wiley +1 more source
Symmetrical drug-related intertriginous and flexural exanthema (SDRIFE) [PDF]
Arnold, A., Bircher, A., Haeusermann, P.
core +1 more source
Fixed Drug Eruptions Due To/Caused by Levocetirizine and Cetirizine: An Uncommon Adverse Cutaneous Drug Reaction to Commonly Used Piperazine Derivatives. [PDF]
Tyagi M +5 more
europepmc +1 more source

