Results 111 to 120 of about 192,321 (311)
Research Progress on Quality Evaluation of Drug-Loaded Contact Lenses
Zhongguo yiliao qixie zazhiAs a novel ocular drug delivery system, drug-loaded contact lenses have overcome the limitations of traditional ophthalmic drug formulations and possess characteristics such as high bioavailability, low toxicity and side effects, and prolonged effective ...
Zhuoyu SONG +5 more
doaj +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Biological and pharmacological investigations of novel diamidines in animal models of human African trypanosomiasis [PDF]
, 2013 "African sleeping sickness, also called human African trypanosomiasis (HAT), results from the infection of humans with either of two protozoan parasites, Trypanosoma brucei gambiense and T. b. rhodesiense. HAT is transmitted by tsetse flies (Glossina spp)
Kibuthu, John Thuita
core +1 more source
Multitask CapsNet: An Imbalanced Data Deep Learning Method for Predicting Toxicants
ACS Omega, 2021 Yiwei Wang +6 more
doaj +1 more source
Advanced ScienceThe efficacy evaluation of anticancer drugs derived from natural products has traditionally relied on animal models, highlighting the need for more efficient preclinical assessment platforms.
Youngwon Kim +7 more
doaj +1 more source
Molecular Oncology, EarlyView.The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant +7 more
wiley +1 more source
Frontiers in Cardiovascular MedicineBackgroundOlanzapine is an atypical antipsychotic used to treat schizophrenia and manic episodes. Its potential thromboembolic risk has been reported, but the evidence remains controversial.
XueSong Zhang +13 more
doaj +1 more source
FEBS Open Bio, EarlyView.Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani +6 more
wiley +1 more source
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
Frontiers in ImmunologyCancer remains a major global health challenge, and although immunotherapy has achieved remarkable breakthroughs, its efficacy is often limited by tumor-induced immunosuppression within the tumor microenvironment (TME).
Xiaoyu Fan +12 more
doaj +1 more source