Results 1 to 10 of about 814,690 (301)
Improving preclinical studies through replications
eLife, 2021 The purpose of preclinical research is to inform the development of novel diagnostics or therapeutics, and the results of experiments on animal models of disease often inform the decision to conduct studies in humans.
Natascha Ingrid Drude +4 more
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Preclinical Studies of Low Back Pain
Molecular Pain, 2013 Chronic low back pain is a major cause of disability and health care costs. Current treatments are inadequate for many patients. A number of preclinical models have been developed that attempt to mimic aspects of clinical conditions that contribute to ...
Judith A Strong +3 more
doaj +3 more sources
Pharmaceutical Toxicology is the Most Important Component of Preclinical Studies
Регуляторные исследования и экспертиза лекарственных средств, 2023 The first principle for ensuring patient safety is to do no harm (primum non nocere). It clearly justifies why the legislative requirements for the safety of medicinal products should be strict and meticulous. The aim of preclinical safety evaluation
A. D. Durnev
doaj +1 more source
Saudi Dental Journal, 2021 The objective of this study is to determine the therapeutic efficacy of allicin against Candida albicans (C. albicans) and Staphylococcus aureus (S. aureus), the common etiological agents for denture stomatitis (DS). The minimum inhibitory concentration (
Mukarramah Zainal +3 more
doaj +1 more source
Scientific Reports, 2021 The widely accepted strategy to justify the use of medicinal plant extracts in diseases with inflammatory background is their examination on in vitro models using immune cells.
Aleksandra Kruk +4 more
doaj +1 more source
In vivo imaging enables high resolution preclinical trials on patients' leukemia cells growing in mice. [PDF]
, 2012 Xenograft mouse models represent helpful tools for preclinical studies on human tumors. For modeling the complexity of the human disease, primary tumor cells are by far superior to established cell lines.
Brentjens, Renier J. +12 more
core +11 more sources
Purified and specific cytoplasmic pollen extract: a non-hormonal alternative for the treatment of menopausal symptoms. [PDF]
, 2020 Research into non-hormonal, alternative therapies is necessary for women for whom menopausal hormone therapy is contraindicated or for women who do not wish to take hormones.
Biglia, Nicoletta +14 more
core +4 more sources
Neuroinflammatory targets and treatments for epilepsy validated in experimental models [PDF]
, 2017 A large body of evidence that has accumulated over the past decade strongly supports the role of inflammation in the pathophysiology of human epilepsy.
Aronica, Eleonora +17 more
core +10 more sources
Natural Antioxidant Application on Fat Accumulation: Preclinical Evidence
Antioxidants, 2021 Obesity represents one of the most important challenges in the contemporary world that must be overcome. Different pathological consequences of these physical conditions have been studied for more than 30 years.
Proshanta Roy +7 more
doaj +1 more source
Cells, 2020 The purpose of this study was to verify the efficacy of a single intra-articular (i.a.) injection of a hyaluronic acid-chitlac (HY-CTL) enriched with two low dosages of triamcinolone acetonide (TA, 2.0 mg/mL and 4.5 mg/mL), in comparison with HY-CTL ...
Matilde Tschon +6 more
doaj +1 more source