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Statistical considerations for preclinical studies [PDF]
Experimental Neurology, 2015 Research studies must always have proper planning, conduct, analysis and reporting in order to preserve scientific integrity. Preclinical studies, the first stage of the drug development process, are no exception to this rule. The decision to advance to clinical trials in humans relies on the results of these studies.
Inmaculada B, Aban, Brandon, George
exaly +3 more sources
Preclinical Studies of Low Back Pain
Molecular Pain, 2013 Chronic low back pain is a major cause of disability and health care costs. Current treatments are inadequate for many patients. A number of preclinical models have been developed that attempt to mimic aspects of clinical conditions that contribute to ...
Judith A Strong +3 more
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Pharmaceutical Toxicology is the Most Important Component of Preclinical Studies
Регуляторные исследования и экспертиза лекарственных средств, 2023 The first principle for ensuring patient safety is to do no harm (primum non nocere). It clearly justifies why the legislative requirements for the safety of medicinal products should be strict and meticulous. The aim of preclinical safety evaluation
A. D. Durnev
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Saudi Dental Journal, 2021 The objective of this study is to determine the therapeutic efficacy of allicin against Candida albicans (C. albicans) and Staphylococcus aureus (S. aureus), the common etiological agents for denture stomatitis (DS). The minimum inhibitory concentration (
Mukarramah Zainal +3 more
doaj +1 more source
Scientific Reports, 2021 The widely accepted strategy to justify the use of medicinal plant extracts in diseases with inflammatory background is their examination on in vitro models using immune cells.
Aleksandra Kruk +4 more
doaj +1 more source
Natural Antioxidant Application on Fat Accumulation: Preclinical Evidence
Antioxidants, 2021 Obesity represents one of the most important challenges in the contemporary world that must be overcome. Different pathological consequences of these physical conditions have been studied for more than 30 years.
Proshanta Roy +7 more
doaj +1 more source
Cells, 2020 The purpose of this study was to verify the efficacy of a single intra-articular (i.a.) injection of a hyaluronic acid-chitlac (HY-CTL) enriched with two low dosages of triamcinolone acetonide (TA, 2.0 mg/mL and 4.5 mg/mL), in comparison with HY-CTL ...
Matilde Tschon +6 more
doaj +1 more source
Improving preclinical studies through replications
eLife, 2021 The purpose of preclinical research is to inform the development of novel diagnostics or therapeutics, and the results of experiments on animal models of disease often inform the decision to conduct studies in humans.
Natascha Ingrid Drude +4 more
doaj +1 more source
Frontiers in Veterinary Science, 2020 The development and utilization of nano-antibiotics is currently gaining attention as a possible solution to antibiotic resistance. The aim of this study was therefore to determine the pharmacokinetics of free oxytetracycline (OTC) and oxytetracycline ...
Sherifat Banke Idris +7 more
doaj +1 more source
Journal of Experimental & Clinical Cancer Research, 2018 Background Bone tissue is one of the main sites for breast metastasis; patients diagnosed with advanced breast cancer mostly develop bone metastasis characterized by severe osteolytic lesions, which heavily influence their life quality.
Valeria Carina +8 more
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