Results 31 to 40 of about 601,377 (310)

Preclinical and Coclinical Studies in Prostate Cancer. [PDF]

, 2020
Men who develop metastatic castration-resistant prostate cancer (mCRPC) will invariably succumb to their disease. Thus there remains a pressing need for preclinical testing of new drugs and drug combinations for late-stage prostate cancer (PCa). Insights
Chen, Ming, Pandolfi, Pier Paolo
core   +1 more source

Species of included preclinical efficacy studies (PCESs). [PDF]

, 2018
Species of included preclinical efficacy studies (PCESs).
William Wei Lim Chin (3212388), Daniel Strech (445126), Carole Federico (5066153), Sören Sievers (5066156), Susanne Wieschowski (3212385), Jonathan Kimmelman (38166)   +5 more
core   +1 more source

Methodological Rigor in Preclinical Cardiovascular Studies [PDF]

, 2017
Rationale: Methodological sources of bias and suboptimal reporting contribute to irreproducibility in preclinical science and may negatively affect research translation. Randomization, blinding, sample
Benjamin Hibbert, Pouya Motazedian, George A. Wells, Zachary D. MacDonald, Pietro Di Santo, Richard G. Jung, Juan J. Russo, F. Daniel Ramirez, Robert Moreland, Aisling A. Clancy, Trevor Simard, Vivian A. Welch   +11 more
core   +1 more source

Dual role of complement in neuronal repair

Frontiers in Immunology
The complement system, long regarded as an arm of innate immunity, is now recognized as an important modulator of nervous system pathophysiology. Following acute injury or in chronic neurodegenerative diseases, promoting neuronal survival and axon ...
Agnieszka Lukomska, Peter Ciesielski, Mariusz Z. Ratajczak, Mariusz Z. Ratajczak, Magdalena Kucia   +4 more
doaj   +1 more source

Characterization, in-silico, and in-vitro study of a new steroid derivative from Ophiocoma dentata as a potential treatment for COVID-19

Scientific Reports, 2022
The medicinal potential of marine invertebrates' bioactive components that may act as anti-COVID-19 demonstrated promising results. Ophiocoma dentata, which is common in the Red Sea, is one such source.
Mohamed S. M. Abd El Hafez, Miral G. AbdEl-Wahab, Mohamed G. Seadawy, Mostafa F. El-Hosseny, Osama Beskales, Ali Saber Ali Abdel-Hamid, Maha A. El Demellawy, Doaa A. Ghareeb   +7 more
doaj   +1 more source

Flowchart for retrieval of preclinical efficacy studies. [PDF]

, 2018
Abbreviations: IB, investigator brochure (for phase I/II clinical trials); IRB, institutional review board; PCES, preclinical efficacy studies (in vivo).
William Wei Lim Chin (3212388), Daniel Strech (445126), Carole Federico (5066153), Sören Sievers (5066156), Susanne Wieschowski (3212385), Jonathan Kimmelman (38166)   +5 more
core   +1 more source

Using Zebrafish in Preclinical Drug Studies: Challenges and Opportunities [PDF]

, 2023
Scientific relevance. Since fiscal and regulatory constraints substantially limit bioscreening in rodent models, a wider implementation of additional alternative models in preclinical studies of medicines is gaining momentum.
A. N. Ikrin, A. V. Kalueff, M. M. Kotova, T. O. Kolesnikova   +3 more
core   +2 more sources

Comparative Analysis of Nutritional Value of Oreochromis niloticus (Linnaeus), Nile Tilapia, Meat from Three Different Ecosystems

Journal of Food Quality, 2017
Determination of protein, lipid, and mineral content of fish meat is necessary to ensure that it meets requirements for food regulations and commercial specifications.
Fanuel Jim, Penina Garamumhango, Colin Musara   +2 more
doaj   +1 more source

TaqMan real-time PCR for detection of pathogenic Leptospira spp. in canine clinical samples

Journal of Veterinary Research, 2023
Canine leptospirosis has always been a differential diagnosis in dogs presenting with clinical signs and blood profiles associated with kidney and/or liver disease.
Rahman Mohammad Sabri Abdul, Khor Kuan Hua, Khairani-Bejo Siti, Lau Seng Fong, Mazlan Mazlina, Roslan Mohd Azri, Ajat Mohd Mokrish Md, Noor Mohd Akmal Mohd   +7 more
doaj   +1 more source

Targeting Sphingolipids for Cancer Therapy

Frontiers in Oncology, 2021
Sphingolipids are an extensive class of lipids with different functions in the cell, ranging from proliferation to cell death. Sphingolipids are modified in multiple cancers and are responsible for tumor proliferation, progression, and metastasis ...
Osmel Companioni, Cristina Mir, Yoelsis Garcia-Mayea, Matilde E. LLeonart, Matilde E. LLeonart   +4 more
doaj   +1 more source