Results 41 to 50 of about 601,377 (310)

Bridging the Gap in Neuroblastoma Care: Consensus‐Based Statements With Recommendations for Improved Patient and Caregiver Experiences

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Neuroblastoma's complex, heterogeneous biology poses significant diagnostic and therapeutic challenges, often requiring caregivers to absorb complex information and participate in time‐sensitive decisions. However, caregivers often feel unprepared to evaluate options.
Vickie Buenger, Joseph Bauer, Jennifer Diamond, Maggie Fader, Shae Hansen, Jacqueline M. Kraveka, Johanna Schoen, Amber Shearer, Dena Sherwood   +8 more
wiley   +1 more source

scRNA-seq revealed transcriptional signatures of human umbilical cord primitive stem cells and their germ lineage origin regulated by imprinted genes

Scientific Reports
A population of CD133+lin-CD45- and CD34+lin-CD45- very small embryonic-like stem cells (VSELs) has been identified in postnatal human tissues, including bone marrow (BM), mobilized peripheral blood (mPB) and umbilical cord blood (UCB). Under appropriate
Justyna Jarczak, Kamila Bujko, Mariusz Z. Ratajczak, Magdalena Kucia   +3 more
doaj   +1 more source

18F-FES radiation dosimetry preliminary estimates for preclinical studies based on voxelized phantom

Brazilian Journal of Radiation Sciences, 2022
Small animals, such as mice, are used in radiopharmaceutical biodistribution studies and innumerous others preclinical investigations involving ionizing radiation.
Andréa Vidal Ferreira, Ana Carolina Araujo Bispo, Christiane Silva Leite, Juliana Batista da Silva, Marcelo Mamede, Rodrigo Modesto Gadelha Gontijo, Bruno Melo Mendes   +6 more
doaj   +1 more source

Natural Killer Cells in Paediatric Soft Tissue Sarcomas: A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Paediatric soft tissue sarcomas (pSTS) are a rare and heterogeneous group of malignant tumours arising in tissues of mesenchymal origin. The role of natural killer (NK) cells in pSTS remains poorly understood, with evidence fragmented across small preclinical studies and early‐phase clinical trials.
Raya Dean, Lara V. Graham, Christina Putnam, Rosa Gomes Alves Martins, Daniel T. Harding, Tim J. Underwood, Zoë S. Walters, Matthew D. Blunt   +7 more
wiley   +1 more source

Pyronaridine tetraphosphate is an efficacious antiviral and anti-inflammatory active against multiple highly pathogenic coronaviruses

mBio, 2023
The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), continues to be one of the largest dangers to human health around the world.
Jeremy Ardanuy, Robert Johnson, Carly Dillen, Louis Taylor, Holly Hammond, Stuart Weston, Matthew Frieman   +6 more
doaj   +1 more source

Which biomaterials may promote periodontal regeneration in intrabony periodontal defects? A systematic review of preclinical studies. [PDF]

, 2014
OBJECTIVE To systematically analyze the regenerative effect of the available biomaterials either alone or in various combinations for the treatment of periodontal intrabony defects as evaluated in preclinical histologic studies.
Ivanovic, Aleksandar, Miron, Richard, Sculean, Anton, Nikou, George, Nikolidakis, Dimitris   +4 more
core   +1 more source

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Commensal Microbiota Effects on Craniofacial Skeletal Growth and Morphology

JBMR Plus, 2023
Microbes colonize anatomical sites in health to form commensal microbial communities (e.g., commensal gut microbiota, commensal skin microbiota, commensal oral microbiota).
Joy E. Gerasco, Jessica D. Hathaway‐Schrader, Nicole A. Poulides, Matthew D. Carson, Naoto Okhura, Caroline Westwater, Nan E. Hatch, Chad M. Novince   +7 more
doaj   +1 more source

Combination of a high-carbohydrate diet and streptozotoc in for modeling type 2 diabetes in Wistar rats

Фармакокинетика и Фармакодинамика, 2023
Relevance. To conduct a preclinical evaluation of the effectiveness of antidiabetic drugs, models simulating the pathogenesis and main manifestations of diabetes mellitus (DM) in humans are needed.
S. V. Ivanov, R. U. Ostrovskaya
doaj   +1 more source

Preclinical Intracranial Aneurysm Models: A Systematic Review [PDF]

, 2020
Intracranial aneurysms (IA) are characterized by weakened cerebral vessel walls that may lead to rupture and subarachnoid hemorrhage. The mechanisms behind their formation and progression are yet unclear and warrant preclinical studies.
Serge Marbacher, Strange, Fabio, Javier Fandino, Marbacher, Serge, Fabio Strange, Fandino, Javier, Basil E Grüter, Gruter, Basil E   +7 more
core   +1 more source