Results 1 to 10 of about 270,343 (177)

Preclinical models for obesity research [PDF]

Disease Models & Mechanisms, 2016
Acknowledgements The authors are funded by the Scottish Government, Rural and Environment Science and Analytical Services Division, Strategic Research Programme, ‘Food, Health and Wellbeing’ Theme. P.B.
Barrett, Perry, Mercer, Julian G, Morgan, Peter J   +2 more
core   +7 more sources

Rabbits in preclinical research [PDF]

Laboratornye Zhivotnye dlya nauchnych issledovanii (Laboratory Animals for Science), 2023
Rabbits are one of the most commonly used laboratory animal species in biomedical research. A large number of models of various human diseases have been developed on rabbits. Rabbits are widely used to assess the safety of substances and pharmaceuticals.
М. Н. Макарова, В. Г. Макаров   +1 more
openalex   +2 more sources

Dirofilariasis mouse models for heartworm preclinical research [PDF]

Frontiers in Microbiology, 2023
ABSTRACTUse of experimental cats and dogs in veterinary heartworm preclinical drug research is increasing. As a potential alternative primaryin vivoheartworm preventative drug screen, we assessed lymphopenic mice with ablation of the interleukin-2/7 common gamma chain (γc) as susceptible to the larval development phase ofD. immitis. Non-obese diabetic (
Amy E. Marriott, Jessica L Dagley, Shrilakshmi Hegde, Andrew Steven, Crystal Fricks, Utami DiCosty, Abdelmoneim Mansour, Edward J. Campbell, Craig M. Wilson, Fabian Gusovsky, Stephen A. Ward, W.D. Hong, Paul M. O’Neill, Autumn Moorhead, S. McCall, John W. McCall, Mark J. Taylor, Joseph D. Turner   +17 more
openalex   +4 more sources

Designing an In Vivo Preclinical Research Study

Surgeries, 2023
During the preclinical research process, multiple factors can be difficult to implement without the careful consideration and planning of each step. As research has become more advanced with the use of increasingly complex technology, animal models have ...
Angel Moctezuma-Ramirez, David Dworaczyk, Julia Whitehorn, Ke Li, Cristiano de Oliveira Cardoso, Abdelmotagaly Elgalad   +5 more
doaj   +3 more sources

Preclinical Models for Bladder Cancer Research

Hematology/Oncology Clinics of North America, 2021
At diagnosis, more than 70% of bladder cancers (BCs) are at the non-muscle-invasive bladder cancer (NMIBC) stages, which are usually treated with transurethral resection followed by intravesical instillation. For the remaining advanced cancers, systemic therapy is the standard of care, with addition of radical cystectomy in cases of locally advanced ...
Shaoming Zhu, Zheng Zhu, Ai‐Hong Ma, Guru Sonpavde, Cheng Fan, Chong‐Xian Pan   +5 more
openalex   +6 more sources

In vivo imaging enables high resolution preclinical trials on patients' leukemia cells growing in mice. [PDF]

, 2012
Xenograft mouse models represent helpful tools for preclinical studies on human tumors. For modeling the complexity of the human disease, primary tumor cells are by far superior to established cell lines.
Brentjens, Renier J., Castro Alves, Catarina, Ehrhardt, Harald, Farkasova, Katarina, Groiss, Volker, Horstmann, Martin, Jeremias, Irmela, Ogris, Manfred, Quintanilla-Martinez, Leticia, Schneider, Katja, Terziyska, Nadia, Wagner, Ernst, zur Stadt, Udo   +12 more
core   +15 more sources

Modulation of tumor immune microenvironment by TAS-115, a multi-receptor tyrosine kinase inhibitor, promotes antitumor immunity and contributes anti-PD-1 antibody therapy

Scientific Reports, 2023
TAS-115 is an oral multi-receptor tyrosine kinase inhibitor that strongly inhibits kinases implicated in antitumor immunity, such as colony stimulating factor 1 receptor and vascular endothelial growth factor receptor.
Toshihiro Shibutani, Risa Goto, Isao Miyazaki, Akihiro Hashimoto, Takamasa Suzuki, Keiji Ishida, Tomonori Haruma, Toshihiro Osada, Takafumi Harada, Hidenori Fujita, Shuichi Ohkubo   +10 more
doaj   +1 more source

TAS1553, a small molecule subunit interaction inhibitor of ribonucleotide reductase, exhibits antitumor activity by causing DNA replication stress

Communications Biology, 2022
A small-molecule protein-protein interaction inhibitor of ribonucleotide reductase subunit, TAS1553, is shown to inhibit growth of both hematological and solid cancer xenograft tumors following oral administration in mice.
Hiroyuki Ueno, Takuya Hoshino, Wakako Yano, Sayaka Tsukioka, Takamasa Suzuki, Shoki Hara, Yoshio Ogino, Khoon Tee Chong, Tatsuya Suzuki, Shingo Tsuji, Hikaru Itadani, Ikuo Yamamiya, Yoshihiro Otsu, Satoshi Ito, Toshiya Yonekura, Miki Terasaka, Nozomu Tanaka, Seiji Miyahara   +17 more
doaj   +1 more source

Preclinical Models: Boosting Synergies for Improved Translation [PDF]

, 2020
The field of preclinical models is a very vast arena, in which finding connections among groups acting in apparently very distant research areas can sometimes prove challenging [...
Attanasio C., Sangiovanni M.
core   +1 more source

Purified and specific cytoplasmic pollen extract: a non-hormonal alternative for the treatment of menopausal symptoms. [PDF]

, 2020
Research into non-hormonal, alternative therapies is necessary for women for whom menopausal hormone therapy is contraindicated or for women who do not wish to take hormones.
Biglia, Nicoletta, Birkhaeuser, Martin, Brincat, Mark, Celis-Gonzales, Cuauhtémoc, Depypere, Herman, Egarter, Christian, Fait, Tomas, Genazzani, Andrea, Goldstein, Steven, Mueck, Alfred, Palacios, Santiago, Panay, Nick, Ruan, Xiangyan, Simoncini, Tommaso, Skouby, Sven O   +14 more
core   +4 more sources