Results 31 to 40 of about 66,456,090 (253)

Development and Optimization of Bifunctional Fusion Proteins to Locally Modulate Complement Activation in Diseased Tissue

Frontiers in Immunology, 2022
Sustained complement activation is an underlying pathologic driver in many inflammatory and autoimmune diseases. Currently approved anti-complement therapies are directed at the systemic blockade of complement.
Kelly C. Fahnoe, Fei Liu, Jennifer G. Morgan, Sarah T. Ryan, Michael Storek, Ellen Garber Stark, Fred R. Taylor, V. Michael Holers, Joshua M. Thurman, Stefan Wawersik, Susan L. Kalled, Shelia M. Violette   +11 more
doaj   +1 more source

5th Internatinal TPCF Preclinical Imaging Symposium

, 2023
Preclinical imaging is the visualization of living animals for research purposes, such as drug development. Imaging modalities have long been crucial to the researcher in observing changes, either at the organ, tissue, cell, or molecular level, in ...
5th Internatinal TPCF Preclinical Imaging
core  

Phase III preclinical trials in translational stroke research

, 2022
S.241-247The multicenter phase III preclinical trial concept is currently discussed to enhance the predictive value of preclinical stroke research. After public announcement, we collected a community feedback on the concept with emphasis on potential ...
Wagner, Daniel-Christoph, Ayata, Cenk, Boltze, Johannes, Plesnila, Nikolaus, Henninger, Nils   +4 more
core   +1 more source

Venetoclax‐Based Therapy as a Bridge to Hematopoietic Stem Cell Transplantation in Relapsed or Refractory Pediatric Acute Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Relapsed and/or refractory (R/R) pediatric acute leukemia carries a dismal prognosis, largely driven by chemoresistance to conventional salvage therapy. The BH3‐mimetic venetoclax, combined with chemotherapy or hypomethylating agents, has demonstrated efficacy in small clinical trials.
Katherine S. Colman, Deborah Meyran, Vajiranee Malalasekera, Heather Weerdenburg, Janine Campbell, Rachel Conyers, Stacie Wang, Hannah Walker, Seong Lin Khaw, Diane Hanna   +9 more
wiley   +1 more source

CRIME-Q—a unifying tool for critical appraisal of methodological (technical) quality, quality of reporting and risk of bias in animal research

BMC Medical Research Methodology
Background Systematic reviews within the field of animal research are becoming more common. However, in animal translational research, issues related to methodological quality and quality of reporting continue to arise, potentially leading to ...
Mikkel Schou Andersen, Mikkel Seremet Kofoed, Asger Sand Paludan-Müller, Christian Bonde Pedersen, Tiit Mathiesen, Christian Mawrin, Birgitte Brinkmann Olsen, Bo Halle, Frantz Rom Poulsen   +8 more
doaj   +1 more source

Regular medical checkup program (in K-MEDI hub) to enhance the welfare of laboratory dogs and pigs

Laboratory Animal Research, 2023
Background The importance of animal welfare is being recognized worldwide. Recently, the increasing demand for enhanced laboratory animal welfare has led to clinically featured transformations of animal research institutes.
Gwang-Hoon Lee, Woori Jo, Joon-Suk Park, Tae-Ku Kang, Soo-Eun Sung, Taeho Oh, KilSoo Kim   +6 more
doaj   +1 more source

Recommendations for robust and reproducible preclinical research in personalised medicine [PDF]

, 2023
Background: Personalised medicine is a medical model that aims to provide tailor-made prevention and treatment strategies for defined groups of individuals.
on behalf of The PERMIT group, ORT Research   +1 more
core  

Classical Complement Pathway Inhibition in a Pediatric Patient With Refractory Immune Thrombocytopenia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric refractory immune thrombocytopenia (rITP) is generally characterized by persistent thrombocytopenia and failure to achieve a sustained response to multiple standard therapies. We report a 4‐year‐old female with congenital tufting enteropathy, post‐intestinal transplant patient on immunosuppressants, who developed severe rITP ...
Sarah Hsieh, Susmita Sarangi, Caileigh Pudela, Catherine M. Broome, Tara K. Suntum   +4 more
wiley   +1 more source

Preclinical Reproducibility and Robustness

, 2016
The Preclinical Reproducibility and Robustness channel on F1000Research has been created to encourage and facilitate open and transparent publication and discussion of confirmatory and non-confirmatory studies in biomedical research.
F1000 Research
core   +2 more sources

A validated preclinical animal model for primary bone tumor research [PDF]

, 2016
Background: Despite the introduction of 21st-century surgical and neoadjuvant treatment modalities, survival of patients with osteosarcoma (OS) has not improved in two decades.
Grifka, Joachim, Loessner, Daniela, Holzapfel, BM, Thibaudeau, Laure, Thibaudeau, L, Joachim Grifka, Ling, Ming-Tat, Daniela Loessner, Holzapfel, Boris M., Boris M. Holzapfel, Ling, M-T, Grifka, J, Dietmar W. Hutmacher, Jean-Pierre Lévesque, Straub, M, Loessner, D, Ferdinand Wagner, Ming-Tat Ling, Levesque, Jean-Pierre, Levesque, J-P, Hutmacher, Dietmar W., Melanie Straub, Wagner, F, Hutmacher, DW, Straub, Melanie, Wagner, Ferdinand, Laure Thibaudeau, Wagner, Ferdinand;Holzapfel, Boris M;Thibaudeau, Laure;Straub, Melanie;Ling, Ming-Tat;Grifka, Joachim;Loessner, Daniela;Lévesque, Jean-Pierre;Hutmacher, Dietmar W   +27 more
core   +1 more source