Preclinical research models for endometrial cancer: development and selection of animal models [PDF]
Frontiers in OncologyEndometrial cancer (EC) is the most common gynecological malignancy in developed countries, with rising incidence in recent years. Experimental animal models are crucial for studying the pathogenesis, advancing diagnostic methods, and developing new ...
Yang Xue +7 more
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Strengthening translational preclinical research through confirmatory multi-laboratory studies [PDF]
Front Med (Lausanne)Sophia Rotter +15 more
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Sex matters in preclinical research [PDF]
Disease Models & MechanismsABSTRACT International Women's Day 2024 has a theme of inclusion. As publishers of preclinical research, we aim to show how inclusion of females in research advances scientific rigor and improves treatment reliability. Sexual reproduction is key to all life across the plant and animal kingdoms.
Justice MJ.
openaire +4 more sources
The Chicken Embryo: An Old but Promising Model for In Vivo Preclinical Research [PDF]
BiomedicinesThe chicken embryo has emerged as a valuable model for preclinical studies due to its unique combination of accessibility, affordability, and relevance to human biology.
Annachiara Sarnella +6 more
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Biochemical changes associated with non-alcoholic fatty liver disease in response to berberine treatment: a systematic review and meta-analysis of clinical and preclinical research [PDF]
Frontiers in PharmacologyBackgroundNon-alcoholic fatty liver disease (NAFLD) represents a global health challenge. Berberine, an isoquinoline alkaloid traditionally used for metabolic disorders, has garnered attention for its potential therapeutic interventions.ObjectiveTo ...
Wenyu Zhu +6 more
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Emerging advances in intestinal models for in vitro preclinical research [PDF]
Am J Physiol Gastrointest Liver PhysiolPrecious Adedayo Adesina +3 more
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Current basic and preclinical research for treatment of radiation therapy–induced hyposalivation [PDF]
JADA Found SciOlga J. Baker +2 more
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Standard operating procedures (SOP) in experimental stroke research: SOP for middle cerebral artery occlusion in the mouse [PDF]
, 2012 Recently, systematic reviews have found quantitative evidence that low study quality may have introduced a bias into preclinical stroke research. Monitoring, auditing, and standard operating procedures (SOPs) are already key elements of quality control ...
Members of the MCAO-SOP Group +1 more
core +2 more sources
Journal of Lipid Research, 1994 Oxidative modifications of lipoproteins appear to contribute to their atherogenicity. Very low and low density lipoproteins (VLDL and LDL) are protected against these modifications by antioxidants that can be incorporated in vivo or in vitro into the ...
C Hallberg +8 more
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Frontiers in Pharmacology, 2023 The 3Rs principles—reduction, refinement, replacement—are at the core of preclinical research within drug discovery, which still relies to a great extent on the availability of models of disease in animals.
Michael Obrecht +6 more
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