Results 11 to 20 of about 66,456,090 (253)

Clinical relevance assessment of animal preclinical research (RAA) tool: development and explanation. [PDF]

, 2021
Only a small proportion of preclinical research (research performed in animal models prior to clinical trials in humans) translates into clinical benefit in humans.
Gurusamy, KS, Barron, Carly C, McHugh, TD, Moher, D., Avey, MT, Osborne, N., Gluud, C, Barron, Carly C., Jell, G, van Laarhoven, Kees, Ahmed, Irfan, Moher, D, Loizidou, Marilena, Katakam, K, Loizidou, M., Ritskes-Hoitinga, Merel, Dwek, M, Lalu, Manoj, Laarhoven, K. van, Avey, M., Ritskes-Hoitinga, M., Katakam, Kiran, Montroy, Joshua, Moher, David, Ahmed, I, Gurusamy, K.S., Avey, Marc T., Barron, CC, Gurusamy, K., Davidson, B, Vollert, J, Loizidou, M, Jell, G., van Laarhoven, K, Dwek, M., Vollert, Jan, Ritskes-Hoitinga, M, Davidson, Brian, Osborne, NJ, Gluud, C., Montroy, J, Lalu, M, McHugh, T.   +42 more
core   +2 more sources

The Sex Inclusive Research Framework to address sex bias in preclinical research proposals. [PDF]

Nat Commun
An interactive Sex Inclusive Research Framework (SIRF) supports the evaluation of in vivo and ex vivo research proposals to address the risk of sex bias in preclinical research.
Karp NA, Berdoy M, Gray K, Hunt L, Jennings M, Kerton A, Leach M, Tremoleda JL, Gledhill J, Pearl EJ, Percie du Sert N, Phillips B, Reynolds PS, Ryder K, Stanford SC, Wells S, Whitfield L.   +16 more
europepmc   +5 more sources

Modulation of tumor immune microenvironment by TAS-115, a multi-receptor tyrosine kinase inhibitor, promotes antitumor immunity and contributes anti-PD-1 antibody therapy

Scientific Reports, 2023
TAS-115 is an oral multi-receptor tyrosine kinase inhibitor that strongly inhibits kinases implicated in antitumor immunity, such as colony stimulating factor 1 receptor and vascular endothelial growth factor receptor.
Toshihiro Shibutani, Risa Goto, Isao Miyazaki, Akihiro Hashimoto, Takamasa Suzuki, Keiji Ishida, Tomonori Haruma, Toshihiro Osada, Takafumi Harada, Hidenori Fujita, Shuichi Ohkubo   +10 more
doaj   +1 more source

TAS1553, a small molecule subunit interaction inhibitor of ribonucleotide reductase, exhibits antitumor activity by causing DNA replication stress

Communications Biology, 2022
A small-molecule protein-protein interaction inhibitor of ribonucleotide reductase subunit, TAS1553, is shown to inhibit growth of both hematological and solid cancer xenograft tumors following oral administration in mice.
Hiroyuki Ueno, Takuya Hoshino, Wakako Yano, Sayaka Tsukioka, Takamasa Suzuki, Shoki Hara, Yoshio Ogino, Khoon Tee Chong, Tatsuya Suzuki, Shingo Tsuji, Hikaru Itadani, Ikuo Yamamiya, Yoshihiro Otsu, Satoshi Ito, Toshiya Yonekura, Miki Terasaka, Nozomu Tanaka, Seiji Miyahara   +17 more
doaj   +1 more source

Irreproducibility –The deadly sin of preclinical research in drug development [PDF]

, 2020
Introduction. In recent years the irreproducibility of preclinical studies has become a serious concern in drug developmental research. The findings of preclinical studies that cannot be reproduced are a drain on public resources and slow down the drug ...
Arumugam, M., Kobayashi, K., Pillai, S.K., Michael, M., Sadasivan Pillai, Sadasivan Kalathil Pillai, Katsumi Kobayashi, Meena Arumugam, Mathews Michael, Meena A   +9 more
core   +1 more source

Magnetic resonance imaging and ultrasound elastography in the context of preclinical pharmacological research: significance for the 3R principles

Frontiers in Pharmacology, 2023
The 3Rs principles—reduction, refinement, replacement—are at the core of preclinical research within drug discovery, which still relies to a great extent on the availability of models of disease in animals.
Michael Obrecht, Stefan Zurbruegg, Nathalie Accart, Christian Lambert, Arno Doelemeyer, Birgit Ledermann, Nicolau Beckmann   +6 more
doaj   +1 more source

StressMatic: A Novel Automated System to Induce Depressive- and Anxiety-like Phenotype in Rats

Cells, 2023
Major depressive disorder (MDD) is a multidimensional psychiatric disorder that is estimated to affect around 350 million people worldwide. Generating valid and effective animal models of depression is critical and has been challenging for neuroscience ...
Joana Martins-Macedo, António Mateus-Pinheiro, Cátia Alves, Fernando Veloso, Eduardo D. Gomes, Inês Ribeiro, Joana S. Correia, Tiago Silveira-Rosa, Nuno D. Alves, Ana J. Rodrigues, João M. Bessa, Nuno Sousa, João F. Oliveira, Patrícia Patrício, Luísa Pinto   +14 more
doaj   +1 more source

Standard operating procedures (SOP) in experimental stroke research: SOP for middle cerebral artery occlusion in the mouse [PDF]

, 2009
Recently, systematic reviews have found quantitative evidence that low study quality may have introduced a bias into preclinical stroke research. Monitoring, auditing, and standard operating procedures (SOPs) are already key elements of quality control ...
Ulrich Dirnagl, Members of the MCAO-SOP Group   +1 more
core   +1 more source

Losing Control in Controlled Settings: Preclinical Human Research on Impulsivity Within the Context of Addiction

, 2023
Purpose of Review: Impulsivity has long been recognized as a risk factor for addiction. The mechanisms through which impulsivity increases risk remain unclear, hindering development of effective impulsivity-targeted addiction treatments.
Natalie J. Loxton, Renata Almeida Mendes, Gullo, Matthew J, Matthew J. Gullo, Lindsay, Hannah J, Hannah J. Lindsay, Mendes, Renata Almeida, Loxton, Natalie J   +7 more
core   +1 more source

Therapeutic Strategies for Spinocerebellar Ataxia Type 1

Biomolecules, 2023
Spinocerebellar ataxia type 1 (SCA1) is an autosomal dominant neurodegenerative disorder that affects one or two individuals per 100,000. The disease is caused by an extended CAG repeat in exon 8 of the ATXN1 gene and is characterized mostly by a ...
Laurie M. C. Kerkhof, Bart P. C. van de Warrenburg, Willeke M. C. van Roon-Mom, Ronald A. M. Buijsen   +3 more
doaj   +1 more source