Results 21 to 30 of about 66,456,090 (253)

Standard operating procedures (SOP) in experimental stroke research: SOP for middle cerebral artery occlusion in the mouse [PDF]

, 2012
Recently, systematic reviews have found quantitative evidence that low study quality may have introduced a bias into preclinical stroke research. Monitoring, auditing, and standard operating procedures (SOPs) are already key elements of quality control ...
Ulrich Dirnagl, Members of the MCAO-SOP Group   +1 more
core   +1 more source

Lipoprotein fractionation in deuterium oxide gradients: a procedure for evaluation of antioxidant binding and susceptibility to oxidation.

Journal of Lipid Research, 1994
Oxidative modifications of lipoproteins appear to contribute to their atherogenicity. Very low and low density lipoproteins (VLDL and LDL) are protected against these modifications by antioxidants that can be incorporated in vivo or in vitro into the ...
C Hallberg, M Hådén, M Bergström, G Hanson, K Pettersson, C Westerlund, G Bondjers, A M Ostlund-Lindqvist, G Camejo   +8 more
doaj   +1 more source

Sex Contextualism

Philosophy, Theory, and Practice in Biology, 2022
This paper develops the conceptual framework of "sex contextualism" for the study of sex-related variables in biomedical research. Sex contextualism offers an alternative to binary sex essentialist approaches to the study of sex as a biological variable.
Sarah S. Richardson
doaj   +2 more sources

Survey on Sheep Usage in Biomedical Research

Animals, 2020
Currently, there is a lack of detailed information about sheep used for biomedical research. Therefore, a European survey was conducted among sheep users gathering information on the current situation, with emphasis on animal selection criteria and ...
Corina Mihaela Berset, Urban Lanker, Stephan Zeiter   +2 more
doaj   +1 more source

Immunogenicity of adenovirus-vector vaccine targeting hepatitis B virus: non-clinical safety assessment in non-human primates

Virology Journal, 2018
Background A new promising therapeutic approach has emerged for patients chronically infected by the hepatitis B virus (HBV) with the development of a non-replicative adenovirus vector vaccine candidate (Ad-HBV).
Xuefeng Zhang, Jing Wang, Jing Lu, Rongrong Li, Shuli Zhao   +4 more
doaj   +1 more source

Correction to: Immunogenicity of adenovirus-vector vaccine targeting hepatitis B virus: non-clinical safety assessment in non-human primates

Virology Journal, 2018
Ad-HBV is a product (T101) aiming to treat chronic HBV firstly developed by Transgene S.A., France then by Transgene Tasly (Tianjin) Biopharmaceutical Co., Ltd., Tianjin, China in China.
Xuefeng Zhang, Jing Wang, Jing Lu, Rongrong Li, Shuli Zhao   +4 more
doaj   +1 more source

In vivo imaging enables high resolution preclinical trials on patients' leukemia cells growing in mice. [PDF]

, 2012
Xenograft mouse models represent helpful tools for preclinical studies on human tumors. For modeling the complexity of the human disease, primary tumor cells are by far superior to established cell lines.
zur Stadt, Udo, Groiss, Volker, Schneider, Katja, Renier J Brentjens, Nadia Terziyska, Harald Ehrhardt, Jeremias, I., Brentjens, Renier J., Farkasova, K., Katja Schneider, Volker Groiss (106787), Katarina Farkasova (106794), Ehrhardt, Harald, Wagner, E., Renier J. Brentjens (106801), Quintanilla-Martinez, Leticia, Martin Horstmann (45040), Ehrhardt, H., Ernst Wagner (60760), Wagner, Ernst, Leticia Quintanilla-Martinez (33277), Terziyska, N., Katja Schneider (106791), Horstmann, M., Brentjens, R.J., Catarina Castro Alves, Quintanilla-Martinez, L., Zur Stadt, U., Horstmann, Martin, Schneider, K., Ogris, M., Manfred Ogris, Alves, C.C., Nadia Terziyska (106777), Terziyska, Nadia, Jeremias, Irmela, Groiss, V., Irmela Jeremias (106806), Volker Groiss, Udo zur Stadt, Martin Horstmann, Farkasova, Katarina, Ernst Wagner, Irmela Jeremias, Ogris, Manfred, Udo zur Stadt (106803), Catarina Castro Alves (106783), Manfred Ogris (60759), Castro Alves, Catarina, Katarina Farkasova, Leticia Quintanilla-Martinez, Harald Ehrhardt (106798)   +51 more
core   +2 more sources

Why clinical translation cannot succeed without failure

eLife, 2015
The high rates of attrition that occur in drug development are widely regarded as problematic, but the failure of well-designed studies benefits both researchers and healthcare systems by, for example, generating evidence about disease theories and ...
Alex John London, Jonathan Kimmelman
doaj   +1 more source

Assessing the Completeness of Reporting in Preclinical Oncolytic Virus Therapy Studies [PDF]

, 2019
Irreproducibility of preclinical findings could be a significant barrier to the “bench-to-bedside” development of oncolytic viruses (OVs). A contributing factor is the incomplete and non-transparent reporting of study methodology and design.
Conic, Isidora, Leung, Garvin J, Lalu, Manoj M, Ilkow, Carolina, Wesch, Neil L, Presseau, Justin, Kimmelman, Jonathan, Cobey, Kelly D, Auer, Rebecca, Diallo, Jean-Simon, MacNeil, Jenna L, Krishnan, Ramya, Kekre, Natasha, El-Sayes, Nader, Keller, Brian A, Fergusson, Dean A   +15 more
core   +1 more source

Standardisation of preclinical PET/CT protocols across multiple research centres [PDF]

, 2020
Preclinical Positron Emission Tomography/Computed Tomography (PET/CT) is a well-established non-invasive imaging tool for studying disease development/progression, the development of novel radiotracers and pharmaceuticals for clinical applications ...
McDougald, Wendy Anne
core   +1 more source