Results 21 to 30 of about 790,668 (339)
StressMatic: A Novel Automated System to Induce Depressive- and Anxiety-like Phenotype in Rats
Cells, 2023 Major depressive disorder (MDD) is a multidimensional psychiatric disorder that is estimated to affect around 350 million people worldwide. Generating valid and effective animal models of depression is critical and has been challenging for neuroscience ...
Joana Martins-Macedo +14 more
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Using the A/T/N framework to examine driving in preclinical Alzheimer’s disease [PDF]
, 2018 The A/T/N classification system is the foundation of the 2018 NIA-AA Research Framework and is intended to guide the Alzheimer disease (AD) research agenda for the next 5–10 years.
Ances, Beau M +9 more
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Preclinical Stroke Research [PDF]
Stroke, 2013 The Stroke Progress Review Group, commissioned by National Institute of Neurological Disorders and Stroke to review the status of stroke research in 2011, addressed a variety of clinical and preclinical areas, including progress and unmet needs in preclinical investigation.1 Identified among the latter were the need to develop better molecular ...
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Therapeutic Strategies for Spinocerebellar Ataxia Type 1
Biomolecules, 2023 Spinocerebellar ataxia type 1 (SCA1) is an autosomal dominant neurodegenerative disorder that affects one or two individuals per 100,000. The disease is caused by an extended CAG repeat in exon 8 of the ATXN1 gene and is characterized mostly by a ...
Laurie M. C. Kerkhof +3 more
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Technological advances in preclinical meta-research [PDF]
BMJ Open Science, 2021 Metaresearch is a scientific field involving the study of research itself. It has been applied to clinical trials since the 1980s,1 but has only become an emerging discipline over the last decade in the preclinical field. The primary tool of metaresearch is the systematic review, which uses predefined methods to provide a transparent and comprehensive ...
Bannach-Brown, A +5 more
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Philosophy, Theory, and Practice in Biology, 2022 This paper develops the conceptual framework of "sex contextualism" for the study of sex-related variables in biomedical research. Sex contextualism offers an alternative to binary sex essentialist approaches to the study of sex as a biological variable.
Sarah S. Richardson
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Xenotransplantation: Current Status in Preclinical Research [PDF]
Frontiers in Immunology, 2020 The increasing life expectancy of humans has led to a growing numbers of patients with chronic diseases and end-stage organ failure. Transplantation is an effective approach for the treatment of end-stage organ failure; however, the imbalance between organ supply and the demand for human organs is a bottleneck for clinical transplantation.
Tianyu Lu +11 more
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Ataxia-Telangiectasia Mutated and the Mre11-Rad50-NBS1 Complex:Promising Targets for Radiosensitization [PDF]
, 2012 Radiotherapy plays a central part in cancer treatment, and use of radiosensitizing agents can greatly enhance this modality. Although studies have shown that several chemotherapeutic agents have the potential to increase the radiosensitivity of tumor ...
Fujiwara, Toshiyoshi +2 more
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Virology Journal, 2018 Background A new promising therapeutic approach has emerged for patients chronically infected by the hepatitis B virus (HBV) with the development of a non-replicative adenovirus vector vaccine candidate (Ad-HBV).
Xuefeng Zhang +4 more
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TNFα induces Ca2+ influx to accelerate extrinsic apoptosis in hepatocellular carcinoma cells [PDF]
, 2018 BACKGROUND: Tumor necrosis factor-α has been proven an effective anticancer agent in preclinical studies. However, the translation of TNFα from research to clinic has been blocked by significant systemic toxicity and limited efficacy at maximal tolerated
Ji, Xiaoying +10 more
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