Results 41 to 50 of about 66,456,090 (253)

National Preclinical Sepsis Platform: developing a framework for accelerating innovation in Canadian sepsis research [PDF]

, 2021
Despite decades of preclinical research, no experimentally derived therapies for sepsis have been successfully adopted into routine clinical practice. Factors that contribute to this crisis of translation include poor representation by preclinical models
Winston, Brent W, Lalu, Manoj M, Charbonney, Emmanuel, Kowalewska, Paulina M, Lansdell, Casey, Cailhier, Jean-François, dos Santos, Claudia, Ellis, Christopher G, Lehmann, Christian, Presseau, Justin, Arora, Jaskirat, Osuchowski, Marcin, Vázquez-Grande, Gloria, Sharma, Neha, Hunniford, Victoria T, Krewulak, Karla, McDonald, Ellen, Dwivedi, Dhruva, Sohrabipour, Sahar, McDonald, Braedon, Cepinskas, Gediminas, Veldhuizen, Ruud A W, Welsh, Donald, Zarychanski, Ryan, Fiest, Kirsten, Fox-Robichaud, Alison E, Macala, Kimberly, Mawdsley, Laura, Muniz, Valdirene S, Mendelson, Asher A, Liaw, Patricia, Marshall, John C, Sunohara-Neilson, Janet, Zhou, Juan, Fergusson, Dean, Hendrick, Kathryn, Gill, Sean E, Medeiros, Sarah K, Zhang, Haibo, Sepsis Canada’s National Preclinical Sepsis Platform, Kimberly Macala, Ryan Zarychanski, Jean-François Cailhier, Victoria T. Hunniford, Gediminas Cepinskas, Neha Sharma, Dean Fergusson, Paulina M. Kowalewska, Janet Sunohara-Neilson, Sean E. Gill, Valdirene S. Muniz, Kirsten Fiest, Kathryn Hendrick, Ruud A. W. Veldhuizen, Alison E. Fox-Robichaud, Justin Presseau, null null, Sarah K. Medeiros, Casey Lansdell, Laura Mawdsley, Karla Krewulak, Christopher G. Ellis, Patricia Liaw, Ellen McDonald, Braedon McDonald, Marcin Osuchowski, Donald Welsh, Brent W. Winston, Dhruva Dwivedi, Haibo Zhang, Jaskirat Arora, Sahar Sohrabipour, Emmanuel Charbonney, Manoj M. Lalu, John C. Marshall, Juan Zhou, Christian Lehmann, Claudia dos Santos, Asher A. Mendelson, Gloria Vázquez-Grande   +79 more
core   +1 more source

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

An Overview of Investigational and Experimental Drug Treatment Strategies for Marfan Syndrome

Journal of Experimental Pharmacology, 2021
Violette Deleeuw, 1 Adelbert De Clercq, 1 Julie De Backer, 1, 2 Patrick Sips 1 1Center for Medical Genetics, Department of Biomolecular Medicine, Ghent University, Ghent, 9000, Belgium; 2Department of Internal Medicine and Pediatrics, Ghent University ...
Deleeuw V, De Clercq A, De Backer J, Sips P   +3 more
doaj  

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

The histopathological and functional consequences of microplastic exposure

Discover Applied Sciences
As the production, usage, and disposal of plastics increase, the microplastics generated—plastic particles smaller than 5 mm—increases, exacerbating environmental pollution.
Yujeong Lee, Minkyoung Sung, Soo-Eun Sung, Joo-Hee Choi, Kyung-Ku Kang, Jae Woo Park, Ye-jin Kim, Sijoon Lee   +7 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Intrinsic macroscale oscillatory modes driving long range functional connectivity in female rat brains detected by ultrafast fMRI

Nature Communications, 2023
The mechanisms which generate fMRI signal correlations across the brain are not fully understood. Here, the authors record ultrafast fMRI signals in anesthetized female rats to demonstrate intrinsic macroscale oscillatory modes which drive correlated ...
Joana Cabral, Francisca F. Fernandes, Noam Shemesh   +2 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Quality Standards of Preclinical Pharmacological Studies

Регуляторные исследования и экспертиза лекарственных средств, 2019
The quality and effectiveness of preclinical trials of medicines depend on compliance with the Good Laboratory Practice (GLP) principles. At the same time, the data of the World Health Organisation (WHO) and the analysis of the regulatory framework ...
G. N. Engalycheva, R. D. Syubaev, D. V. Goryachev   +2 more
doaj   +1 more source