Results 41 to 50 of about 790,668 (339)

Quality and validity of large animal experiments in stroke : a systematic review [PDF]

, 2020
An important factor for successful translational stroke research is study quality. Low-quality studies are at risk of biased results and effect overestimation, as has been intensely discussed for small animal stroke research.
Bahor, Z., Boltze, Johannes, Herrmann, A. M., Kringe, L., Meckel, S., Motschall, E., Mülling, C., Sena, E. S., Wang, Q.   +8 more
core   +4 more sources

Development and Optimization of Bifunctional Fusion Proteins to Locally Modulate Complement Activation in Diseased Tissue

Frontiers in Immunology, 2022
Sustained complement activation is an underlying pathologic driver in many inflammatory and autoimmune diseases. Currently approved anti-complement therapies are directed at the systemic blockade of complement.
Kelly C. Fahnoe, Fei Liu, Jennifer G. Morgan, Sarah T. Ryan, Michael Storek, Ellen Garber Stark, Fred R. Taylor, V. Michael Holers, Joshua M. Thurman, Stefan Wawersik, Susan L. Kalled, Shelia M. Violette   +11 more
doaj   +1 more source

Remodeling of Intrahepatic Ducts in a Model of Caroli Syndrome: Is Scar Carcinoma a Consequence of Laplace’s Law?

Medical Sciences, 2019
Caroli syndrome, characterized by saccular dilatation of intrahepatic ducts and congenital hepatic fibrosis, is without therapy in part due to its ultra-rare prevalence and the apparent lack of availability of a suitable experimental model. While the PCK
Bharvi M. Chavre, Kai Jiang, Luce G. St. Surin, Terrence Bissoondial, Ping Zhou, Jingsong Li, Satishkumar V. Gadhiya, Itzhak D. Goldberg, Prakash Narayan   +8 more
doaj   +1 more source

Predicting Alzheimer's risk: why and how? [PDF]

, 2011
Because the pathologic processes that underlie Alzheimer's disease (AD) appear to start 10 to 20 years before symptoms develop, there is currently intense interest in developing techniques to accurately predict which individuals are most likely to become
Barnes, Deborah E, Lee, Sei J
core   +2 more sources

Why clinical translation cannot succeed without failure

eLife, 2015
The high rates of attrition that occur in drug development are widely regarded as problematic, but the failure of well-designed studies benefits both researchers and healthcare systems by, for example, generating evidence about disease theories and ...
Alex John London, Jonathan Kimmelman
doaj   +1 more source

Fluoxetine: a case history of its discovery and preclinical development [PDF]

, 2014
Introduction: Depression is a multifactorial mood disorder with a high prevalence worldwide. Until now, treatments for depression have focused on the inhibition of monoaminergic reuptake sites, which augment the bioavailability of monoamines in the CNS ...
Bel N, Bergstrom RF, Bravo L, Bremner JD, Burrows GD, Chouinard G, Datla KP, Esther Berrocoso, Juan Antonio Mico, Kreiss DS, Laura Perez-Caballero, Lemberger L, Li Q, Lidia Bravo, Maj J, Nibuya M, Owens MJ, Rutter JJ, Sonia Torres-Sanchez, Stevens JC, Wong DT   +20 more
core   +2 more sources

Regular medical checkup program (in K-MEDI hub) to enhance the welfare of laboratory dogs and pigs

Laboratory Animal Research, 2023
Background The importance of animal welfare is being recognized worldwide. Recently, the increasing demand for enhanced laboratory animal welfare has led to clinically featured transformations of animal research institutes.
Gwang-Hoon Lee, Woori Jo, Joon-Suk Park, Tae-Ku Kang, Soo-Eun Sung, Taeho Oh, KilSoo Kim   +6 more
doaj   +1 more source

Neuroactive steroids in depression and anxiety disorders: Clinical studies [PDF]

, 2006
Certain neuroactive steroids modulate ligand-gated ion channels via non-genomic mechanisms. Especially 3 alpha-reduced pregnane steroids are potent positive allosteric modulators of the gamma-aminobutyric acid type A (GABA(A)) receptor.
Akwa Y, Baghai TC, Baker ER, Barrett-Connor E, Bicikova M, Bitran D, Bloch M, Brambilla F, Brambilla F, Brambilla F, Cornelius Schüle, Crawley JN, Dalton K, Daniela Eser, Dennerstein L, Dong E, Elena Romeo, Eser D, Evans RM, Fabian TJ, Freeman E, Freeman EW, Friess E, George MS, Goodyer IM, Guidotti A, Heydari B, Heydary B, Kita A, Koszycki D, Lawrie TA, Maayan R, Magill PJ, Majewska MD, Majewska MD, Majewska MD, Matsumoto K, Meieran SE, Melchior CL, Melchior CL, Mensah-Nyagan AG, Mienville JM, Monnet FP, Padberg F, Papadopoulos V, Paul SM, Purdy RH, Rainer Rupprecht, Reddy DS, Reddy DS, Reddy DS, Rodgers RJ, Romeo E, Rupprecht R, Rupprecht R, Schmidt PJ, Schule C, Schule C, Semeniuk T, Serra M, Serra M, Strohle A, Strohle A, Strohle A, Strous RD, Takebayashi M, Thomas C. Baghai, Tollefson GD, Trauger JW, Urani A, Uzunov DP, Uzunova V, Uzunova V, Uzunova V, Vanselow W, Wieland S, Wolkowitz OM, Wolkowitz OM, Wu FS, Zwanzger P   +79 more
core   +1 more source

CRIME-Q—a unifying tool for critical appraisal of methodological (technical) quality, quality of reporting and risk of bias in animal research

BMC Medical Research Methodology
Background Systematic reviews within the field of animal research are becoming more common. However, in animal translational research, issues related to methodological quality and quality of reporting continue to arise, potentially leading to ...
Mikkel Schou Andersen, Mikkel Seremet Kofoed, Asger Sand Paludan-Müller, Christian Bonde Pedersen, Tiit Mathiesen, Christian Mawrin, Birgitte Brinkmann Olsen, Bo Halle, Frantz Rom Poulsen   +8 more
doaj   +1 more source

Update and New Insights on Future Cancer Drug Candidates From Plant-Based Alkaloids

Frontiers in Pharmacology, 2021
Cancer is a complex multifactorial disease that results from alterations in many physiological and biochemical functions. Over the last few decades, it has become clear that cancer cells can acquire multidrug resistance to conventional anticancer drugs ...
Mounir Tilaoui, Hassan Ait Mouse, Abdelmajid Zyad   +2 more
doaj   +1 more source