Preclinical progression of neurodegenerative diseases [PDF]
, 2018 2018-08Neurodegenerative diseases are disorders that are characterized by a progressive decline of the motor and/or cognitive function caused by a selective loss of neurons within the central nervous system.
Hashizume, Atsushi +3 more
core +1 more source
Results of quality assessment of preclinical studies. [PDF]
, 2021 Results showing that study design such as inclusion of proper control groups, randomization and blinding, reporting of key items on animal characteristic such as gender and strain and needs to be improved in preclinical studies on TEHVs. (DOCX)
M. Uiterwijk (11524558) +5 more
core +1 more source
Standard operating procedures (SOP) in experimental stroke research: SOP for middle cerebral artery occlusion in the mouse [PDF]
, 2009 Recently, systematic reviews have found quantitative evidence that low study quality may have introduced a bias into preclinical stroke research. Monitoring, auditing, and standard operating procedures (SOPs) are already key elements of quality control ...
Ulrich Dirnagl +1 more
core +2 more sources
Statistical considerations for preclinical studies [PDF]
Experimental Neurology, 2015 Research studies must always have proper planning, conduct, analysis and reporting in order to preserve scientific integrity. Preclinical studies, the first stage of the drug development process, are no exception to this rule. The decision to advance to clinical trials in humans relies on the results of these studies.
Inmaculada B, Aban, Brandon, George
openaire +2 more sources
Assessing the Completeness of Reporting in Preclinical Oncolytic Virus Therapy Studies [PDF]
, 2019 Irreproducibility of preclinical findings could be a significant barrier to the “bench-to-bedside” development of oncolytic viruses (OVs). A contributing factor is the incomplete and non-transparent reporting of study methodology and design.
Conic, Isidora +15 more
core +1 more source
Interregional compensatory mechanisms of motor functioning in progressing preclinical neurodegeneration. [PDF]
, 2013 Understanding brain reserve in preclinical stages of neurodegenerative disorders allows determination of which brain regions contribute to normal functioning despite accelerated neuronal loss.
Scheller, Elisa +18 more
core +1 more source
Experimental study of the pharmacological activity of new azaheterocycles derivatives: A literature review [PDF]
Ķazaķstannyṇ Klinikalyķ Medicinasy, 2022 Diseases associated with the pathology of the cardiovascular system are one of the key causes of death all over the world. In particular, arrhythmia may entail the most severe complications, including unexpected death.
Malika Khaiitova +4 more
doaj +1 more source
Standard operating procedures (SOP) in experimental stroke research: SOP for middle cerebral artery occlusion in the mouse [PDF]
, 2012 Recently, systematic reviews have found quantitative evidence that low study quality may have introduced a bias into preclinical stroke research. Monitoring, auditing, and standard operating procedures (SOPs) are already key elements of quality control ...
Ulrich Dirnagl +1 more
core +2 more sources
Scientific Reports, 2022 Lantana camara L. is widely used in folk medicine for alleviation of inflammatory disorders, but studies that proved this folk use and that revealed the molecular mechanism of action in inflammation mitigation are not enough.
Alaa A. El-Banna +5 more
doaj +1 more source
Flow and selection of preclinical studies. [PDF]
, 2018 Flow and selection of preclinical studies.
Stephanie E. W. Punt (5429711) +2 more
core +1 more source