Results 21 to 30 of about 13,024,078 (298)

Preclinical Studies on Pulsatile Veno-Arterial Extracorporeal Membrane Oxygenation: A Systematic Review

, 2023
Refractory cardiogenic shock is increasingly being treated with veno-arterial extracorporeal membrane oxygenation (V-A ECMO), without definitive proof of improved clinical outcomes.
Dhayananth Kanagarajan, Kanagarajan, Dhayananth, Gandini, Lucia, Suen, Jacky Y, Pauls, Jo, Heinsar, Silver, Jo Pauls, John F. Fraser, Suen, Jacky Y., Fraser, John F., Van Thanh Dau, Jacky Y. Suen, Dau, Van Thanh, Fraser, John F, Lucia Gandini, https://orcid.org/, Silver Heinsar   +16 more
core   +1 more source

Effectiveness of sacubitril-valsartan in patients with cancer therapy-related cardiac dysfunction (CTRCD): a systematic review of clinical and preclinical studies

, 2022
Cancer therapy-related cardiac dysfunction (CTRCD) is a critical problem with an impact on both oncological and cardiovascular prognosis, especially when it prevents patients from receiving cancer treatment.
Neto, Mansueto G, Tse, Gary, Biondi-Zoccai, Giuseppe, Mesquita, Evandro T, Roever, Leonardo, Chan, Jeffrey S, Duraes, Andre R, Liu, Tong, Bitar, Yasmin S, Boochi, Edimar A   +9 more
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Interregional compensatory mechanisms of motor functioning in progressing preclinical neurodegeneration. [PDF]

, 2013
Understanding brain reserve in preclinical stages of neurodegenerative disorders allows determination of which brain regions contribute to normal functioning despite accelerated neuronal loss.
Scheller, Elisa, Peter, J, Peter, Jessica, Scheller, E., Peter, J., Abdulkadir, Ahmed, Frackowiak, Richard S. J., Frackowiak, R.S., Klöppel, Stefan, Tabrizi, S.J., Frackowiak, Richard S.J., Abdulkadir, A, Tabrizi, SJ, Frackowiak, RS, Scheller, E, Klöppel, S., Tabrizi, Sarah J., Abdulkadir, A., Klöppel, S   +18 more
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Assessing the Completeness of Reporting in Preclinical Oncolytic Virus Therapy Studies [PDF]

, 2019
Irreproducibility of preclinical findings could be a significant barrier to the “bench-to-bedside” development of oncolytic viruses (OVs). A contributing factor is the incomplete and non-transparent reporting of study methodology and design.
Conic, Isidora, Leung, Garvin J, Lalu, Manoj M, Ilkow, Carolina, Wesch, Neil L, Presseau, Justin, Kimmelman, Jonathan, Cobey, Kelly D, Auer, Rebecca, Diallo, Jean-Simon, MacNeil, Jenna L, Krishnan, Ramya, Kekre, Natasha, El-Sayes, Nader, Keller, Brian A, Fergusson, Dean A   +15 more
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Experimental study of the pharmacological activity of new azaheterocycles derivatives: A literature review [PDF]

Ķazaķstannyṇ Klinikalyķ Medicinasy, 2022
Diseases associated with the pathology of the cardiovascular system are one of the key causes of death all over the world. In particular, arrhythmia may entail the most severe complications, including unexpected death.
Malika Khaiitova, Aida Seitaliyeva, Elmira Satbayeva, Daniya Serdalieva, Talgat Nurgozhin   +4 more
doaj   +1 more source

Metabolic profiling of Lantana camara L. using UPLC-MS/MS and revealing its inflammation-related targets using network pharmacology-based and molecular docking analyses

Scientific Reports, 2022
Lantana camara L. is widely used in folk medicine for alleviation of inflammatory disorders, but studies that proved this folk use and that revealed the molecular mechanism of action in inflammation mitigation are not enough.
Alaa A. El-Banna, Reham S. Darwish, Doaa A. Ghareeb, Abdelrahman M. Yassin, Shaymaa A. Abdulmalek, Hend M. Dawood   +5 more
doaj   +1 more source

Standard operating procedures (SOP) in experimental stroke research: SOP for middle cerebral artery occlusion in the mouse [PDF]

, 2012
Recently, systematic reviews have found quantitative evidence that low study quality may have introduced a bias into preclinical stroke research. Monitoring, auditing, and standard operating procedures (SOPs) are already key elements of quality control ...
Ulrich Dirnagl, Members of the MCAO-SOP Group   +1 more
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5th Internatinal TPCF Preclinical Imaging Symposium

, 2023
Preclinical imaging is the visualization of living animals for research purposes, such as drug development. Imaging modalities have long been crucial to the researcher in observing changes, either at the organ, tissue, cell, or molecular level, in ...
5th Internatinal TPCF Preclinical Imaging
core  

Dual role of complement in neuronal repair

Frontiers in Immunology
The complement system, long regarded as an arm of innate immunity, is now recognized as an important modulator of nervous system pathophysiology. Following acute injury or in chronic neurodegenerative diseases, promoting neuronal survival and axon ...
Agnieszka Lukomska, Peter Ciesielski, Mariusz Z. Ratajczak, Mariusz Z. Ratajczak, Magdalena Kucia   +4 more
doaj   +1 more source

TaqMan real-time PCR for detection of pathogenic Leptospira spp. in canine clinical samples

Journal of Veterinary Research, 2023
Canine leptospirosis has always been a differential diagnosis in dogs presenting with clinical signs and blood profiles associated with kidney and/or liver disease.
Rahman Mohammad Sabri Abdul, Khor Kuan Hua, Khairani-Bejo Siti, Lau Seng Fong, Mazlan Mazlina, Roslan Mohd Azri, Ajat Mohd Mokrish Md, Noor Mohd Akmal Mohd   +7 more
doaj   +1 more source