Results 11 to 20 of about 601,377 (310)

Quality Standards of Preclinical Pharmacological Studies [PDF]

Регуляторные исследования и экспертиза лекарственных средств, 2019
The quality and effectiveness of preclinical trials of medicines depend on compliance with the Good Laboratory Practice (GLP) principles. At the same time, the data of the World Health Organisation (WHO) and the analysis of the regulatory framework ...
G. N. Engalycheva, R. D. Syubaev, D. V. Goryachev   +2 more
doaj   +3 more sources

Vaccines with adjuvants. Preclinical studies [PDF]

Биопрепараты: Профилактика, диагностика, лечение, 2018
The paper presents the data on safety and efficacy assessment of adjuvants and vaccines with adjuvants at the stages of development and preclinical studies based on international recommendations.
Zh. I. Avdeeva, N. A. Alpatova, V. P. Bondarev, R. A. Volkova, N. I. Lonskaya, E. V. Lebedinskaya, N. V. Medunitsyn, A. N. Mironov, N. A. Ozeretskovsky, A. A. Soldatov, V. A. Shevtsov   +10 more
doaj   +2 more sources

Preclinical Studies in the Pharmaceutical Development Cycle [PDF]

Регуляторные исследования и экспертиза лекарственных средств
The ultimate goal of preclinical studies is to generate data that can be used to make conclusions about the potential effects of a new medicine on the human body and to properly proceed to clinical trials. In this interview, Marina N. Makarova, Doctor of
M. N. Makarova
doaj   +2 more sources

Ethical implications of preclinical studies [PDF]

Регуляторные исследования и экспертиза лекарственных средств, 2018
Animal experiments are fundamental for the biomedical science. The development of new drugs is always associated with a large number of preclinical experiments in animals.
I. N. Tyurenkov, E. M. Lomkina, D. V. Kurkin, D. A. Bakulin, E. V. Volotova   +4 more
doaj   +2 more sources

Should Peak Dose Be Used to Prescribe Spatially Fractionated Radiation Therapy?—A Review of Preclinical Studies [PDF]

, 2022
SIMPLE SUMMARY: This review study analyzed preclinical studies available before 2022 on spatially fractionated radiation therapy (SFRT), a promising cancer therapy with a high therapeutic index. We intend to use the results of preclinical studies to shed
Prezado, Yolanda, Yolanda Prezado, Sha Chang, Fernandez-Palomo, Cristian, Chang, Sha, Cristian Fernandez-Palomo   +5 more
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Preclinical Studies on Pulsatile Veno-Arterial Extracorporeal Membrane Oxygenation: A Systematic Review [PDF]

, 2023
Refractory cardiogenic shock is increasingly being treated with veno-arterial extracorporeal membrane oxygenation (V-A ECMO), without definitive proof of improved clinical outcomes.
Dhayananth Kanagarajan, Kanagarajan, Dhayananth, Gandini, Lucia, Suen, Jacky Y, Pauls, Jo, Heinsar, Silver, Jo Pauls, John F. Fraser, Suen, Jacky Y., Fraser, John F., Van Thanh Dau, Jacky Y. Suen, Dau, Van Thanh, Fraser, John F, Lucia Gandini, https://orcid.org/, Silver Heinsar   +16 more
core   +1 more source

Effectiveness of sacubitril-valsartan in patients with cancer therapy-related cardiac dysfunction (CTRCD): a systematic review of clinical and preclinical studies [PDF]

, 2022
Cancer therapy-related cardiac dysfunction (CTRCD) is a critical problem with an impact on both oncological and cardiovascular prognosis, especially when it prevents patients from receiving cancer treatment.
Neto, Mansueto G, Tse, Gary, Biondi-Zoccai, Giuseppe, Mesquita, Evandro T, Roever, Leonardo, Chan, Jeffrey S, Duraes, Andre R, Liu, Tong, Bitar, Yasmin S, Boochi, Edimar A   +9 more
core   +1 more source

Clinical relevance assessment of animal preclinical research (RAA) tool: development and explanation. [PDF]

, 2021
Only a small proportion of preclinical research (research performed in animal models prior to clinical trials in humans) translates into clinical benefit in humans.
Gurusamy, KS, Barron, Carly C, McHugh, TD, Moher, D., Avey, MT, Osborne, N., Gluud, C, Barron, Carly C., Jell, G, van Laarhoven, Kees, Ahmed, Irfan, Moher, D, Loizidou, Marilena, Katakam, K, Loizidou, M., Ritskes-Hoitinga, Merel, Dwek, M, Lalu, Manoj, Laarhoven, K. van, Avey, M., Ritskes-Hoitinga, M., Katakam, Kiran, Montroy, Joshua, Moher, David, Ahmed, I, Gurusamy, K.S., Avey, Marc T., Barron, CC, Gurusamy, K., Davidson, B, Vollert, J, Loizidou, M, Jell, G., van Laarhoven, K, Dwek, M., Vollert, Jan, Ritskes-Hoitinga, M, Davidson, Brian, Osborne, NJ, Gluud, C., Montroy, J, Lalu, M, McHugh, T.   +42 more
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Cannabinoid therapies in the management of sleep disorders: A systematic review of preclinical and clinical studies [PDF]

, 2020
Cannabinoids, including the two main phytocannabinoids Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD), are being increasingly utilised as pharmacological interventions for sleep disorders.
Suraev, Anastasia S, Hoyos, Camilla M, McCartney, Danielle, Vandrey, Ryan, Grunstein, Ronald R, Marshall, Nathaniel S, McGregor, Iain S, Benson, Melissa J   +7 more
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In vivo imaging enables high resolution preclinical trials on patients' leukemia cells growing in mice. [PDF]

, 2012
Xenograft mouse models represent helpful tools for preclinical studies on human tumors. For modeling the complexity of the human disease, primary tumor cells are by far superior to established cell lines.
zur Stadt, Udo, Groiss, Volker, Schneider, Katja, Renier J Brentjens, Nadia Terziyska, Harald Ehrhardt, Jeremias, I., Brentjens, Renier J., Farkasova, K., Katja Schneider, Volker Groiss (106787), Katarina Farkasova (106794), Ehrhardt, Harald, Wagner, E., Renier J. Brentjens (106801), Quintanilla-Martinez, Leticia, Martin Horstmann (45040), Ehrhardt, H., Ernst Wagner (60760), Wagner, Ernst, Leticia Quintanilla-Martinez (33277), Terziyska, N., Katja Schneider (106791), Horstmann, M., Brentjens, R.J., Catarina Castro Alves, Quintanilla-Martinez, L., Zur Stadt, U., Horstmann, Martin, Schneider, K., Ogris, M., Manfred Ogris, Alves, C.C., Nadia Terziyska (106777), Terziyska, Nadia, Jeremias, Irmela, Groiss, V., Irmela Jeremias (106806), Volker Groiss, Udo zur Stadt, Martin Horstmann, Farkasova, Katarina, Ernst Wagner, Irmela Jeremias, Ogris, Manfred, Udo zur Stadt (106803), Catarina Castro Alves (106783), Manfred Ogris (60759), Castro Alves, Catarina, Katarina Farkasova, Leticia Quintanilla-Martinez, Harald Ehrhardt (106798)   +51 more
core   +1 more source