Results 11 to 20 of about 13,024,078 (298)

Quality Standards of Preclinical Pharmacological Studies [PDF]

Регуляторные исследования и экспертиза лекарственных средств, 2019
The quality and effectiveness of preclinical trials of medicines depend on compliance with the Good Laboratory Practice (GLP) principles. At the same time, the data of the World Health Organisation (WHO) and the analysis of the regulatory framework ...
G. N. Engalycheva, R. D. Syubaev, D. V. Goryachev   +2 more
doaj   +2 more sources

Vaccines with adjuvants. Preclinical studies [PDF]

Биопрепараты: Профилактика, диагностика, лечение, 2018
The paper presents the data on safety and efficacy assessment of adjuvants and vaccines with adjuvants at the stages of development and preclinical studies based on international recommendations.
Zh. I. Avdeeva, N. A. Alpatova, V. P. Bondarev, R. A. Volkova, N. I. Lonskaya, E. V. Lebedinskaya, N. V. Medunitsyn, A. N. Mironov, N. A. Ozeretskovsky, A. A. Soldatov, V. A. Shevtsov   +10 more
doaj   +1 more source

Preclinical Studies in the Pharmaceutical Development Cycle

Регуляторные исследования и экспертиза лекарственных средств
The ultimate goal of preclinical studies is to generate data that can be used to make conclusions about the potential effects of a new medicine on the human body and to properly proceed to clinical trials. In this interview, Marina N. Makarova, Doctor of
M. N. Makarova
doaj   +2 more sources

Ethical implications of preclinical studies [PDF]

Регуляторные исследования и экспертиза лекарственных средств, 2018
Animal experiments are fundamental for the biomedical science. The development of new drugs is always associated with a large number of preclinical experiments in animals.
I. N. Tyurenkov, E. M. Lomkina, D. V. Kurkin, D. A. Bakulin, E. V. Volotova   +4 more
doaj   +1 more source

Should Peak Dose Be Used to Prescribe Spatially Fractionated Radiation Therapy?—A Review of Preclinical Studies [PDF]

, 2022
SIMPLE SUMMARY: This review study analyzed preclinical studies available before 2022 on spatially fractionated radiation therapy (SFRT), a promising cancer therapy with a high therapeutic index. We intend to use the results of preclinical studies to shed
Prezado, Yolanda, Yolanda Prezado, Sha Chang, Fernandez-Palomo, Cristian, Chang, Sha, Cristian Fernandez-Palomo   +5 more
core   +2 more sources

Clinical relevance assessment of animal preclinical research (RAA) tool: development and explanation. [PDF]

, 2021
Only a small proportion of preclinical research (research performed in animal models prior to clinical trials in humans) translates into clinical benefit in humans.
Gurusamy, KS, Barron, Carly C, McHugh, TD, Moher, D., Avey, MT, Osborne, N., Gluud, C, Barron, Carly C., Jell, G, van Laarhoven, Kees, Ahmed, Irfan, Moher, D, Loizidou, Marilena, Katakam, K, Loizidou, M., Ritskes-Hoitinga, Merel, Dwek, M, Lalu, Manoj, Laarhoven, K. van, Avey, M., Ritskes-Hoitinga, M., Katakam, Kiran, Montroy, Joshua, Moher, David, Ahmed, I, Gurusamy, K.S., Avey, Marc T., Barron, CC, Gurusamy, K., Davidson, B, Vollert, J, Loizidou, M, Jell, G., van Laarhoven, K, Dwek, M., Vollert, Jan, Ritskes-Hoitinga, M, Davidson, Brian, Osborne, NJ, Gluud, C., Montroy, J, Lalu, M, McHugh, T.   +42 more
core   +1 more source

In vivo imaging enables high resolution preclinical trials on patients' leukemia cells growing in mice. [PDF]

, 2012
Xenograft mouse models represent helpful tools for preclinical studies on human tumors. For modeling the complexity of the human disease, primary tumor cells are by far superior to established cell lines.
zur Stadt, Udo, Groiss, Volker, Schneider, Katja, Renier J Brentjens, Nadia Terziyska, Harald Ehrhardt, Jeremias, I., Brentjens, Renier J., Farkasova, K., Katja Schneider, Volker Groiss (106787), Katarina Farkasova (106794), Ehrhardt, Harald, Wagner, E., Renier J. Brentjens (106801), Quintanilla-Martinez, Leticia, Martin Horstmann (45040), Ehrhardt, H., Ernst Wagner (60760), Wagner, Ernst, Leticia Quintanilla-Martinez (33277), Terziyska, N., Katja Schneider (106791), Horstmann, M., Brentjens, R.J., Catarina Castro Alves, Quintanilla-Martinez, L., Zur Stadt, U., Horstmann, Martin, Schneider, K., Ogris, M., Manfred Ogris, Alves, C.C., Nadia Terziyska (106777), Terziyska, Nadia, Jeremias, Irmela, Groiss, V., Irmela Jeremias (106806), Volker Groiss, Udo zur Stadt, Martin Horstmann, Farkasova, Katarina, Ernst Wagner, Irmela Jeremias, Ogris, Manfred, Udo zur Stadt (106803), Catarina Castro Alves (106783), Manfred Ogris (60759), Castro Alves, Catarina, Katarina Farkasova, Leticia Quintanilla-Martinez, Harald Ehrhardt (106798)   +51 more
core   +2 more sources

Preclinical progression of neurodegenerative diseases [PDF]

, 2018
2018-08Neurodegenerative diseases are disorders that are characterized by a progressive decline of the motor and/or cognitive function caused by a selective loss of neurons within the central nervous system.
Hashizume, Atsushi, Sahashi, Kentaro, Katsuno, Masahisa, Iguchi, Yohei   +3 more
core   +1 more source

Preparation, characterization and in vitro cytotoxicity evaluation of free and liposome-encapsulated tylosin

OpenNano, 2022
Liposomes are the most attractive and well-known nanoparticles due to their high biocompatibility and biodegradability features which make them display less toxic effects for employing in vivo.
Mohammad Ehsan Saddiqi, Arifah Abdul Kadir, Faez Firdaus Jesse Abdullah, Md Zuki Abu Bakar Zakaria, Idris Sherifat Banke   +4 more
doaj   +1 more source

Standard operating procedures (SOP) in experimental stroke research: SOP for middle cerebral artery occlusion in the mouse [PDF]

, 2009
Recently, systematic reviews have found quantitative evidence that low study quality may have introduced a bias into preclinical stroke research. Monitoring, auditing, and standard operating procedures (SOPs) are already key elements of quality control ...
Ulrich Dirnagl, Members of the MCAO-SOP Group   +1 more
core   +1 more source