Results 121 to 130 of about 8,240,920 (301)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Recent Advances in the Study of Traditional Chinese Medicine in Reversing Hepatic Fibrosis Through the Regulation of Hepatic Stellate Cells Apoptosis Pathways

Drug Design, Development and Therapy
Ruihan Cheng, Baolong Li Drug Safety Evaluation Center, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang Province, 150006, People’s Republic of ChinaCorrespondence: Baolong Li, Drug Safety Evaluation Center, Heilongjiang University of ...
Cheng R, Li B
doaj  

Impact of the FDA roadmap and perspectives for regulatory use of new approach methodologies in Japanese pharmaceutical companies

NAM Journal
Pharmaceutical scientists develop and apply increasingly complex technologies from an expanding toolbox to create more effective and safer drugs.
Tetsuro Araki, Hitoshi Naraoka, Yuta Asakawa, Toru Usui, Dai Kakiuchi, Seiichiro Kurashige, Tadahiro Shinozawa, Kimika Nakamura, Takumi Noda, Satomi Nishikawa, Mutsumi Suzuki   +10 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Elements of effective drug education. [PDF]

, 2011
The Drug Education Forum's paper on the learning cycle looks at each element of the cycle covering guidance on needs assessment, planning, delivery/intervention, reflection and assessment and evaluation.

core  

Evaluation and Mitigation of Time‐Dependent Confounding Effects in Conventional Exposure‐Response Analyses for Oncology Drugs

CPT: Pharmacometrics & Systems Pharmacology
Conventional exposure–response (E–R) analyses, such as logistic regression and time‐to‐event analysis using summary exposure metrics, are often conducted in oncology using data from the pivotal trial(s) with a single dose level to support dosing ...
Xuefen Yin, Ye Xiong, Youwei Bi, Xin Wei, Hong Zhao, Elimika Pfuma Fletcher, Rajanikanth Madabushi, Amal Ayyoub, Hao Zhu, Stephan Schmidt, Jiang Liu   +10 more
doaj   +1 more source

Evaluation of Drugs for Angina [PDF]

BMJ, 1963
openaire   +2 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Bioinspired microfluidic approach for cell-based drug evaluation

, 2011
Cell-based drug evaluation is critical for the process of drug screening and drug discovery ...Cell-based drug evaluation is critical for the process of drug screening and drug discovery ..
秦建华, JianhuaQin
core