Results 161 to 170 of about 8,240,920 (301)

Three-dimensional patient-derived endometriosis model for drug evaluation. [PDF]

Acta Obstet Gynecol Scand
Li Y, Shao W, Gao X, Wang Y, Li J, Zhang L, Xing Y, Su W, Cheng Y, Wang L, Liu S.   +10 more
europepmc   +1 more source

Human skin-on-a-chip for mpox pathogenesis studies and preclinical drug evaluation. [PDF]

Trends Pharmacol Sci, 2023
Zhu J, Abaci HE.
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Rucaparib - drug evaluation: a PARP inhibitor for the treatment of BRCA-mutated metastatic castration-resistant prostate cancer. [PDF]

Future Oncol
Bryce AH, Nash P, Roessler A, Mandair D.
europepmc   +1 more source

Biomimetic lung-on-a-chip to model virus infection and drug evaluation. [PDF]

Eur J Pharm Sci, 2023
Tan J, Guo Q, Tian L, Pei Z, Li D, Wu M, Zhang J, Gao X.   +7 more
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Evaluation of SWSLHD Aboriginal Outreach Drug & Alcohol Clinics in Airds and Bowral: Overarching Report

, 2018
Aboriginal people experience a disproportionate amount of the harms associated with use of substances such as alcohol, illicit drugs and pharmaceuticals. Treatment is one component of a multifaceted approach to reducing the impact of drug-related harm on
Blignault, Ilse (R18379)
core  

Survival of ethnic and racial minority patients with multiple myeloma treated with newer medications

Blood Advances, 2018
E. Dianne Pulte, Lei Nie, Nicole Gormley, Kirsten B. Goldberg, Amy McKee, Ann Farrell, Richard Pazdur   +6 more
doaj   +1 more source

Corrigendum: PKM2-Induced the Phosphorylation of Histone H3 Contributes to EGF-Mediated PD-L1 Transcription in HCC

Frontiers in Pharmacology, 2021
Xiao Wang, Chao Liang, Xin Yao, Ruo-Han Yang, Zhan-Sheng Zhang, Fan-Ye Liu, Wen-Qi Li, Shu-Hua Pei, Jing Ma, Song-Qiang Xie, Song-Qiang Xie, Dong Fang   +11 more
doaj   +1 more source

Bladder cancer precision-cut tumor slices (PCTS) preserve functional immune microenvironment enabling ex vivo drug evaluation. [PDF]

BMC Med
Richtmann S, Radak M, Sincic V, Hugoson J, Werner N, Skoryk V, Wagner D, Liedberg F, Lundberg K.   +8 more
europepmc   +1 more source