Results 191 to 200 of about 18,950,887 (401)

Inhibition of EED-mediated histone methylation alleviates neuroinflammation by suppressing WNT-mediated dendritic cell migration

Journal of Neuroinflammation
The epigenetic modification of histone H3 lysine 27 trimethylation (H3K27me3) by the embryonic ectoderm development (EED) protein is closely associated with the regulation of transcriptional programs and is implicated in autoimmune diseases. However, the
Wenxiang Hong, Hongbo Ma, Zhibin Li, Yiwen Du, Wenjing Xia, Han Yin, Han Huang, Zebing Sun, Renhua Gai, Lexian Tong, Hong Zhu, Jincheng Wang, Bo Yang, Qiaojun He, Qinjie Weng, Jiajia Wang   +15 more
doaj   +1 more source

EVALUATION OF CARDIAC DRUGS IN THE PRESENCE OF AN ELECTRICAL PACEMAKER

, 1964
P Grondin, G Lepage, Jean-Pierre Guignard, A. Karamehmet, Edouard D. Gagnon   +4 more
openalex   +1 more source

Ten-Year Experience for the Center for Drug Evaluation and Research, Part 2: FDA’s Role in Ensuring Patient Safety

Therapeutic Innovation and Regulatory Science, 2017
J. Jarow, S. Lemery, Kevin Bugin, Naomi Lowy   +3 more
semanticscholar   +1 more source

Comparison between sodium iodate and lipid peroxide murine models of age-related macular degeneration for drug evaluation-a narrative review. [PDF]

Ann Eye Sci, 2022
Kim SY, Qian H.
europepmc   +1 more source

Evaluation of Drugs for Angina [PDF]

BMJ, 1963
openaire   +3 more sources

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

THE CLINICAL EVALUATION OF NARCOTIC AND SEDATIVE DRUGS H: A RE-EVALUATION OF PETHIDINE AND PETHILORFAN

, 1965
David G. Campbell, A.H.B. MASSON, Walter Norris   +2 more
openalex   +1 more source

WHEN IS DOUBLE‐BLIND DRUG EVALUATION IMPROPER? [PDF]

, 1975
Mortimer Lorber
openalex   +1 more source

Clinical and pharmacokinetic drug evaluation of delafloxacin for the treatment of acute bacterial skin and skin structure infections

Expert Opinion on Drug Metabolism & Toxicology, 2017
M. Bassetti, D. Pecori, P. Cojutti, E. Righi, F. Pea   +4 more
semanticscholar   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source