Results 201 to 210 of about 1,122,477 (316)

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

Rapid Processing and Drug Evaluation in Glioblastoma Patient-Derived Organoid Models with 4D Bioprinted Arrays. [PDF]

iScience, 2020
Chadwick M, Yang C, Liu L, Gamboa CM, Jara K, Lee H, Sabaawy HE.   +6 more
europepmc   +1 more source

Evaluation of drugs for elimination of leukemic cells from the bone marrow of patients with acute leukemia [PDF]

, 1988
ML Auber, LJ Horwitz, A. A. M. Blaauw, S Khorana, Stephen B. Tucker, T Woods, M Warmuth, Dicke Ka, KB McCredie, Gary Spitzer   +9 more
openalex   +1 more source

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

Studies on drug dependence Rept. 19: Quantitative evaluation of reinforcing effect on drug-seeking behavior

, 1974
Tomoji Yanagita, Nagaoki Oinuma
openalex   +1 more source

Evaluation of drug-antibody conjugates in the treatment of human myelosarcomas transplanted in nude mice [PDF]

, 1980
Zulkiflee Abd Latif, B B Lozzio, Carl J. Wust, S Krauß, Mario Carlos Aggio, Carmen B. Lozzio   +5 more
openalex   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

All-Optical Electrophysiology Refines Populations of In Silico Human iPSC-CMs for Drug Evaluation. [PDF]

Biophys J, 2020
Paci M, Passini E, Klimas A, Severi S, Hyttinen J, Rodriguez B, Entcheva E.   +6 more
europepmc   +1 more source

CLINICAL EVALUATION OF DRUG EFTICACY BY THE DOUBLE BLIND METHOD IN MEDICINE

, 1976
N Shimizu
openalex   +2 more sources

The evaluation of different types of anti‐convulsant drug activity against leptazol‐induced epileptogenic activity in the anaesthetized rat [PDF]

, 1983
Ashley Kent, R.A. Webster
openalex   +1 more source