Results 211 to 220 of about 18,950,887 (401)

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Evaluation of Antianginal Drugs on Rabbits by Electrocardiographic Technique

, 1969
RIICHIRO IWAKI, TOSHITAKA KUDO, Jun-ichi Ishiko, Tsutomu Irikura   +3 more
openalex   +2 more sources

Drug therapeutic evaluation in acute myocardial infarction. [PDF]

, 1972
A P Fletcher
openalex   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Manufacturing Uniform Cerebral Organoids for Neurological Disease Modeling and Drug Evaluation. [PDF]

Biomater Res
Hong H, Jun Y, Yoon SB, Park S, Lee J, Jang JW, Nam HJ, Cho H.   +7 more
europepmc   +1 more source

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

Formulation and Evaluation of Vanishing Herbal Cream of Crude Drugs

, 1970
Shinde Prajakta, Khule Shahu
openalex   +2 more sources

Three-dimensional in vitro tumor models for cancer research and drug evaluation.

Biotechnology Advances, 2014
Xian Xu, M. Farach-Carson, Xinqiao Jia
semanticscholar   +1 more source

Bioprinting of a multi-composition array to mimic intra-tumor heterogeneity of glioblastoma for drug evaluation. [PDF]

Microsyst Nanoeng
Lee G, Kim SJ, Choi Y, Park J, Park JK.
europepmc   +1 more source

The Evaluation of New Drugs

Journal of Pharmacy and Pharmacology, 1958
Leonard G Goodwin, Frank L Rose
openaire   +3 more sources