Results 221 to 230 of about 18,950,887 (401)

Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?

Molecular Oncology, EarlyView.
Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley   +1 more source

Model ecosystem evaluation of the environmental impacts of the veterinary drugs phenothiazine, sulfamethazine, clopidol, and diethylstilbestrol.

, 1976
Joel R. Coats, Robert L. Metcalf, P Y Lu, Daniel D. Brown, J F Williams, Loren Hansen   +5 more
openalex   +1 more source

The Application of Enzyme Histochemistry To Drug Safety Evaluation [PDF]

, 1973
H Kief, K. Engelbart
openalex   +1 more source

Human PBMC-based humanized mice exhibit myositis features and serve as a drug evaluation model. [PDF]

Inflamm Regen
Nishidate A, Takemoto K, Imura Y, Murase M, Yamanaka R, Kikuchi M, Anan J, Kato S, Akatsuka A, Mochizuki S, Koda Y.   +10 more
europepmc   +1 more source

Generation of Angiotensin-Converting Enzyme 2/Transmembrane Protease Serine 2-Double-Positive Human Induced Pluripotent Stem Cell-Derived Spheroids for Anti-Severe Acute Respiratory Syndrome Coronavirus 2 Drug Evaluation. [PDF]

Microbiol Spectr, 2022
Higashi-Kuwata N, Yabe SG, Fukuda S, Nishida J, Tamura-Nakano M, Hattori SI, Okochi H, Mitsuya H.   +7 more
europepmc   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

Lung cancer organoid-based drug evaluation models and new drug development application trends. [PDF]

Transl Lung Cancer Res
Lee E, Lee SY, Seong YJ, Ku B, Cho HJ, Kim K, Hwang Y, Park CK, Choi JY, Kim SW, Kim SJ, Lim JU, Yeo CD, Lee DW.   +13 more
europepmc   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Studies on the pharmaceutical quality evaluation of crude drug preparations used in orient medicine "Kampoo". III. Precipitation reaction of glycyrrhizin with alkaloids or alkaloidal crude drugs in aqueous solution.

, 1978
Mamoru Noguchi, Michinori Kubo, Teruaki Hayashi, MEIZI ONO   +3 more
openalex   +2 more sources

Construction of a lung cancer 3D culture model based on alginate/gelatin micro-beads for drug evaluation. [PDF]

Transl Lung Cancer Res
Zhao Z, Feng X, Wu H, Chen S, Ma C, Guan Z, Lei L, Tang K, Chen X, Dong Y, Tang Y.   +10 more
europepmc   +1 more source