Results 251 to 260 of about 18,950,887 (401)

Evaluation of drug-induced changes in myocardial repolarisation using the paced evoked response. [PDF]

, 1982
Robert M. Donaldson, A F Rickards
openalex   +1 more source

Primary biliary cholangitis drug evaluation and regulatory approval: Where do we go from here? [PDF]

Hepatology
Jones DEJ, Beuers U, Bonder A, Carbone M, Culver E, Dyson J, Gish RG, Hansen BE, Hirschfield G, Jones R, Kowdley K, Kremer AE, Lindor K, Mayo M, Mells G, Neuberger J, Prince M, Swain M, Tanaka A, Thorburn D, Trauner M, Trivedi P, Weltman M, Yeoman A, Levy C.   +24 more
europepmc   +1 more source

Dose‐dependent induction of epithelial‐mesenchymal transition in 3D melanoma models by non‐thermal plasma treatment

Molecular Oncology, EarlyView.
Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop, Edgar Cardenas De La Hoz, Hanne Verswyvel, Joey De Backer, Ho Wa Lau, Angela Privat‐Maldonado, Wim Vanden Berghe, Steve Vanlanduit, Evelien Smits, Annemie Bogaerts, Abraham Lin   +10 more
wiley   +1 more source

Evaluation of intranasal delivery route of drug administration for brain targeting

Brain Research Bulletin, 2018
F. Erdő, L. Bors, Dániel Farkas, Ágnes Bajza, S. Gizurarson   +4 more
semanticscholar   +1 more source

Suitability of external controls for drug evaluation in Duchenne muscular dystrophy. [PDF]

Neurology, 2020
Goemans N, Signorovitch J, Sajeev G, Yao Z, Gordish-Dressman H, McDonald CM, Vandenborne K, Miller D, Ward SJ, Mercuri E, investigators from PRO-DMD-01 Study, CINRG DNHS, ImagingDMD, and the DMD Italian Group.   +13 more
europepmc   +1 more source

Evaluation of Drug-Drug Interactions in Drug Development.

Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics, 2003
Dipti M. Amin, Jean-Pierre Isal
openaire   +3 more sources

Molecular imaging predicts trastuzumab‐deruxtecan (T‐DXd) response in head and neck cancer xenograft models

Molecular Oncology, EarlyView.
Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed, Lucas Mani, Muhammad Bilal Mirza, Ashtyn McAdoo, Takahito Kondo, Hidenori Tanaka, Nicole Meeks, Eben Rosenthal, Marisa Hom   +8 more
wiley   +1 more source

Strong Binding of Leupeptin with TMPRSS2 Protease May Be an Alternative to Camostat and Nafamostat for SARS-CoV-2 Repurposed Drug: Evaluation from Molecular Docking and Molecular Dynamics Simulations. [PDF]

Appl Biochem Biotechnol, 2021
Ramakrishnan J, Kandasamy S, Iruthayaraj A, Magudeeswaran S, Chinnasamy K, Poomani K.   +5 more
europepmc   +1 more source

Loss of primary cilia promotes EphA2‐mediated endothelial‐to‐mesenchymal transition in the ovarian tumor microenvironment

Molecular Oncology, EarlyView.
Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho, Yubin Hah, Eunsik Yun, Hye In Ka, Aram Lee, Sora Han, Dawn Lee, Sung Wook Kim, Jong Hoon Park, Byung Su Kwon, Young Yang, Jongmin Kim   +11 more
wiley   +1 more source

EEG brain mapping in evaluating the time‐course of the central action of DUP 996‐a new acetylcholine releasing drug. [PDF]

, 1989
B. Saletu, A. Darragh, Paul M. Salmon, Robert F. Coen   +3 more
openalex   +1 more source