Results 121 to 130 of about 222,974 (348)

Loss of Tripartite Motif–Containing Protein 21 and UVB‐Induced Systemic Inflammation by Regulating DNA‐Sensing Pathways

Arthritis &Rheumatology, EarlyView.
Objective Patients with systemic lupus erythematosus (SLE) experience photosensitivity, with exposure to UVB light driving lupus flares and triggering symptoms like joint pain, fatigue, and cutaneous lesions. Although the mechanism(s) linking UVB exposure to systemic effects are unclear, type I interferons (IFNs) are known to play a role.
Gantsetseg Tumurkhuu, Graziela Perri, Richard Moore, Lihong Huo, Arati Naveen Kumar, Richard Ainsworth, Trinitee Oliver, Gabriela De Los Santos, David Gibb, Jessica Carriere, Jeong Min Yu, Rachel Abuav, Lindsy Forbess, Daniel J. Wallace, Mariko Ishimori, Wonwoo Shon, Christian Stehlik, Caroline A. Jefferies   +17 more
wiley   +1 more source

Oxaliplatin-induced type II hypersensitivity in colorectal cancer: a cohort study on clinical presentation, diagnosis, and management

Frontiers in Pharmacology
BackgroundOxaliplatin (OXL) is a key treatment for colorectal cancer but can potentially induce type II hypersensitivity reactions (II-HSRs), leading to immune-mediated cytopenias.
Paula Vázquez-Revuelta, Paula Vázquez-Revuelta, Paula Vázquez-Revuelta, Paula Vázquez-Revuelta, Ricardo Madrigal-Burgaleta, Ricardo Madrigal-Burgaleta, J. Carlos Ruffinelli, Enric Casanovas, Ana Coloma, Ana Coloma, Ramon Lleonart, Ramon Lleonart   +11 more
doaj   +1 more source

Sense and sensitisation: in vitro testing for hepatotoxic drug hypersensitivity [PDF]

, 1997
Jeremy Woodward, James Neuberger
openalex   +1 more source

Plasma Proteomics Identifies TAOK3 as a Potential Biomarker of Rheumatoid Arthritis Activity and a Novel Therapeutic Target

Arthritis &Rheumatology, Accepted Article.
Objective Bone destruction associated with active rheumatoid arthritis (RA) remains a major therapeutic challenge, with a lack of reliable molecular markers reflecting bone injury. This study aims to identify novel biomarkers linked to bone destruction in active RA through proteomic analysis, providing new strategies for precise monitoring and targeted
Pengfei Xin, Wenzhen Li, Xinyu A, Jun Shen, Xiaohui Meng, Yanqin Bian, Haihui Han, Zheng Xiang, Lei Ran, Songtao Sun, Jun Xie, Tao Yue, Qi Zhu, Xiaoming Zhang, Lu Xie, Lianbo Xiao   +15 more
wiley   +1 more source

Altered Auditory Maturation in Fragile X Syndrome and Its Involvement in Audiogenic Seizure Susceptibility

Autism Research, EarlyView.
ABSTRACT Auditory hypersensitivity is a prominent symptom in Fragile X syndrome (FXS), the most prevalent monogenic cause of autism and intellectual disability. FXS arises through the loss of the protein encoded by the FMR1 (Fragile X Messenger Ribonucleoprotein 1) gene, FMRP, required for normal neural circuit excitability.
Dorit Möhrle, Demi Ma, Wenyue Xue, Jun Yan, Ning Cheng   +4 more
wiley   +1 more source

Desensitization for the Prevention of Drug Hypersensitivity [PDF]

, 2023
Jeong-Eun Yun, Ji-Ung Jeong, Hye‐Ryun Kang   +2 more
openalex   +1 more source

DRUG HYPERSENSITIVITY IN PRE-SCHOOL CHILDREN [PDF]

, 2016
Introdução: As reações de hipersensibilidade medicamen¬tosa (RHM) são reacções adversas reprodutíveis que se carac¬terizam por sintomas típicos de alergia que surgem após admi-nistração de doses terapêuticas habituais.
Abreu, Carmo, Gomes, Eva Rebelo, Viana, Jorge da Costa   +2 more
core  

Adverse immunostimulation in early phase clinical trials: Key findings and recommendations based on the investigator's clinical experience

British Journal of Clinical Pharmacology, EarlyView.
Problem setting The emergence of therapeutic proteins has coincided with an increase of acute adverse immunostimulation (AIS). AIS has occured in clinical trials despite compliance with regulatory guidelines on preclinical evaluation and its incidence is anticipated to increase even further.
Juliette A. van den Noort, Marella C. E. van Ruissen, Lisanne C. A. Smidt, Naomi B. Klarenbeek, Philip H. K. Kremer, Manon A. A. Jansen, Jacobus Burggraaf, Joop M. A. van Gerven, Matthijs Moerland   +8 more
wiley   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Altered microbiome of serum exosomes in patients with acute and chronic cholecystitis

BMC Microbiology
Background This study aimed to investigate the differences in the microbiota composition of serum exosomes from patients with acute and chronic cholecystitis.
Qing Zhu, Min-Xian Li, Ming-Chin Yu, Qi-Wen Ma, Ming-Jie Huang, Chun-Wei Lu, Chun-Bing Chen, Wen-Hung Chung, Chih-Jung Chang   +8 more
doaj   +1 more source