Results 111 to 120 of about 1,960,750 (298)

The Value of Enzyme-linked Immunospot Assay in Identifying Causative Agents in Patients with Hypersensitivity Reactions to Antitubercular Agents [PDF]

Zhongguo quanke yixue
Background Hypersensitivity reactions of antitubercular agents are very common in clinical practice. Drug provocation test is the only effective method to find out the causative agents, but it may cause re-sensitization or even shock, which can be life ...
WU Yuqing, LIU Zhou, LIAO Yongmei
doaj   +1 more source

Multiple drug hypersensitivity: normal Treg cell function but enhanced in vivo activation of drug-specific T cells

, 2011
Up to 10% of patients with severe immune-mediated drug hypersensitivity reactions have tendencies to develop multiple drug hypersensitivities (MDH). The reason why certain individuals develop MDH and the underlying pathomechanism are unclear.
Lerch, M, Groux-Keller, M, Park, B K, Naisbitt, D J, Wendland, T, Hausmann, O V, D. J. Naisbitt, T. Kawabata, Daubner, B, B. K. Park, M. Lerch, Pichler, W J, B. Daubner, W. J. Pichler, M. Groux-Keller, O. V. Hausmann, Kawabata, T, T. Wendland   +17 more
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New approaches to investigate drug-induced hypersensitivity [PDF]

, 2016
The workshop on "New Approaches to Investigate Drug-Induced Hypersensitivity" was held on June 5, 2014 at the Foresight Center, University of Liverpool. The aims of the workshop were to (1) discuss our current understanding of the genetic, clinical, and ...
Whritenour, J, Norris, Alan, Meng, X, Park, Brian Kevin, Hirschfield, Gideon M., French, Neil, Naisbitt, DJ, Martin, SF, Gibson, Andrew, Dickinson, Anne, Musette, Philippe, Gibson, A, Spraggs, CF, Alferivic, A, Betts, CJ, Betts, Catherine J, Norris, A, Purcell, Anthony Wayne, Pirmohamed, Munir, Martin, Stefan F, Kammueller, Michael, Musette, P, Martin, Stefan F., Pirmohamed, M, Alferivic, Ana, Alfirevic, Ana, Kammüller, Michael, Kammuller, M, Naisbitt, Dean J., Spraggs, Colin F., Faulkner, L, Hirschfield, Gideon M, Purcell, AW, Park, B. Kevin, French, N, Ogese, Monday O., Spraggs, Colin F, Naisbitt, Dean John, Whritenour, Jessica, Ogese, Monday O, Park, BK, Hirschfield, GM, Kammüller, Michael Ernst, Ahmed, S, Ahmed, Shaheda, Faulkner, Lee, Purcell, Anthony W., Ogese, MO, French, Neil S, Meng, Xiaoli, Betts, Catherine J., Dickinson, A   +51 more
core   +1 more source

Navigating Asparaginase Treatment for Patients With Acute Lymphoblastic Leukemia: US Consensus Panel Recommendations on the Role of Multidisciplinary Care

American Journal of Hematology, EarlyView.
ABSTRACT Asparaginase is a critical treatment component for patients with acute lymphoblastic leukemia/lymphoblastic lymphoma (ALL/LBL). However, the successful delivery of asparaginase‐based therapy remains challenging across care settings due to its complex administration, distinct toxicity profile, prolonged treatment duration, and the need for ...
Amir Ali, Grace Elsey, Kayla Fulginiti, Zanette Kanani‐Bradley, Holly R. Kubaney, Sandra Kurtin, Theresa Nguyen, Jennifer Turchina, Charlotte B. Wagner   +8 more
wiley   +1 more source

CD69 upregulation on T cells as an in vitro marker for delayed-type drug hypersensitivity

, 2007
BACKGROUND: T cells play a key role in delayed-type drug hypersensitivity reactions. Their reactivity can be assessed by their proliferation in response to the drug in the lymphocyte transformation test (LTT).
W. J. Pichler, L. Zaccaria, B. O. Gerber, A. Beeler, Zaccaria, L, T. Kawabata, Beeler, A, Kawabata, T, Gerber, B O, Pichler, W J   +9 more
core   +1 more source

Adipose‐derived mesenchymal stem cell injection into the KI10 acupoint mitigates cartilage damage in KOA rats through PGE2‐mediated α7nAChR/NF‐κB pathway

Animal Models and Experimental Medicine, EarlyView.
In our research, KOA rat models were established and treated with ADSC injection into the KI10 acupoint. Pain relief, behavioral function, and joint structural improvements were systematically assessed using ethological tests, imaging, histopathological staining, transmission electron microscopy, and molecular analyses.
Mengwei Dong, Wenfang Li, Wanpeng Yang, Te Ba, Nan Nan, Yang Liu, Jing Han, Huiqin Hao   +7 more
wiley   +1 more source

High sensitivity of human leukocyte antigen–B*5701 as a marker for immunologically confirmed abacavir hypersensitivity in white and black patients [PDF]

, 2008
Background. Although the human leukocyte antigen (HLA)-B*5701 is highly associated with a hypersensitivity reaction (HSR) to abacavir (ABC), variable sensitivities have been reported when clinical data alone have been used to define an ABC HSR.
Stancil, B., Balu, R., Mosteller, M., Wannamaker, P., Phillips, E.J., Saag, M., Burman, W., Brothers, C., Brachman, P., Hughes, A., Sutherland‐Phillips, D., Martorell, C., Mallal, S., Shaefer, M.   +13 more
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Pharmacogenetics of hypersensitivity drug reactions

, 2017
Adverse drug reactions are a significant cause of morbidity and mortality and represent a major burden on the healthcare system. Some of those reactions are immunologically mediated (hypersensitivity reactions) and can be clinically subdivided into two ...
NEGRINI, SIMONE, Becquemont, Laurent
core   +1 more source

Safety and Feasibility of Magnetic Separation‐Based Blood Purification

Advanced NanoBiomed Research, EarlyView.
We present the preclinical biological safety and translational feasibility of a magnetic nanoparticle‐based extracorporeal blood purification platform for removal of disease‐causing blood factors. ISO 10993‐compliant studies and exaggerated worst‐case exposure models demonstrate efficient nanoparticle extraction (≥99.9%), favorable biocompatibility ...
Carlos A. Mora, Laurine Rijsbergen, Jan Waskowski, Gaelle Clermont, Florian Dingreville, Chandrashekara Vishwanath, Rajesh Karunanithi, Alexander Gogos, Jean‐Claude Metzger, Manuel Baumgartner, Joerg C. Schefold, Inge K. Herrmann   +11 more
wiley   +1 more source

Factors associated with different responses to combination antiretroviral therapy in an observational cohort study of HIV-1 infected patients [PDF]

, 2008
The introduction of combination antiretroviral therapy (cART) into clinical practice for the treatment of HIV in 1995-1996 has led to dramatic reductions in mortality and morbidity. Factors linked to a positive response to therapy include a potent and
Bannister, W.P., Bannister, W P
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