Results 91 to 100 of about 144,000 (291)

HLA-DRB1 is associated with cefaclor-induced immediate hypersensitivity

World Allergy Organization Journal
Background: Drug-induced hypersensitivity such as anaphylaxis is an important cause of drug-related morbidity and mortality. Cefaclor is a leading cause of drug induced type I hypersensitivity in Korea, but little is yet known about genetic biomarkers to
So-Young Park, MD, PhD, So Young Park, MD, PhD, Sujin Seo, BS, Hyouk-Soo Kwon, MD, PhD, Seung-Hyun Kim, PhD, Sae-Hoon Kim, MD, PhD, Hye-Kyung Park, MD, PhD, Yoon-Seok Chang, MD, PhD, Cheol-Woo Kim, MD, PhD, Byung Jae Lee, MD, PhD, Hae-Sim Park, MD, PhD, You Sook Cho, MD, PhD, Heung-Bum Oh, PhD, David A. Ostrov, PhD, Sungho Won, PhD, Tae Bum Kim, MD, PhD   +15 more
doaj   +1 more source

The Potential Role of Synovial T Cell Infiltration Following Knee Joint Injury in Symptoms and Progression to Osteoarthritis

Arthritis &Rheumatology, EarlyView.
Objective Identification of osteoarthritis (OA)–specific synovial inflammatory pathways and their temporal relevance is critical for therapeutic targeting. We compared mononuclear inflammatory/immune cell responses following joint injury that does or does not lead to OA to define bona fide OA‐associated cellular events.
Babak Moradi, Miriam T. Jackson, Cindy C. Shu, Susan M. Smith, Margaret M. Smith, Sanaa Zaki, Hadrian Platzer, Nils Rosshirt, David Giangreco, Carla R. Scanzello, Christopher B. Little   +10 more
wiley   +1 more source

Self-report prevalence and associated factors to drug hypersensitivity in Mexican young adults [PDF]

, 2017
Background: Drug hypersensitivity is defined as any unfavorable reaction that occurs after the administration of any drug. It may or may not be mediated by the involvement of the immune system.
DOMINGUEZ GARCIA, MA VICTORIA, BEDOLLA BARAJAS, MARTIN; 317804, FLORES MERINO, MIRIAM VERONICA; 178028, PUENTE FERNANDEZ, CECILIA; 544686, FLORES MERINO, MIRIAM VERONICA, BEDOLLA BARAJAS, MARTIN, PUENTE FERNANDEZ, CECILIA, DOMINGUEZ GARCIA, MA VICTORIA; 85954, MORALES ROMERO, JAIME; 210880, MORALES ROMERO, JAIME   +9 more
core  

HLA and the Pharmacogenomics of Drug Hypersensitivity

, 2014
Adverse drug reactions (ADRs) represent a tremendous source of morbidity, mortality and cost in modern medicine. The human leukocyte antigen (HLA) genes are highly polymorphic and encode proteins that are integral to T-cell-mediated immunity to ...
White, K.D., Gaudieri, S., Silvana Gaudieri, Elizabeth J. Phillips, Phillips, E.J., Katie D. White   +5 more
core   +1 more source

Nerve Growth Factor is Sufficient to Cause Multiple Osteoarthritis‐Relevant Pathologic Features in Naïve Murine Knee Joints

Arthritis &Rheumatology, EarlyView.
Objective Nerve growth factor (NGF), a key mediator of pain, is increased in osteoarthritic (OA) joints. Antibodies against NGF show analgesic effects in painful knee OA, but clinical development was stopped because of side effects in the joints. Knowledge about the biologic effects of NGF on joint tissues is limited. Therefore, we explored the effects
Alia M. Obeidat, Michael D. Newton, Jun Li, Baofeng Hu, Shingo Ishihara, Lindsey Lammlin, Lucas M. Junginger, Easton C. Farrell, Lai Wang, Frank C. Ko, Richard J. Miller, Carla R. Scanzello, Tristan Maerz, Rachel E. Miller, Anne‐Marie Malfait   +14 more
wiley   +1 more source

Pro and Contra: Provocation Tests in Drug Hypersensitivity

, 2017
Drug provocation test (DPT) is the controlled administration of a drug to diagnose immune- or non-immune-mediated drug hypersensitivity and the last step for accurate recognition of drug hypersensitivity reactions when the previous diagnostic evaluations
Soyer, O, Ozge Soyer, Soyer, Ozge, Umit Murat Sahiner, Bulent Enis Sekerel, Sahiner, Umit Murat, Sekerel, Bulent Enis   +6 more
core   +1 more source

Hypersensitivity to chemotherapeutic drugs for the treatment of neoplasms. Literature review

Infusion & Chemotherapy
BACKGROUND. Like any other drug, chemotherapy drugs can cause hypersensitivity reactions and are the third leading cause of drug-induced anaphylaxis deaths in the United States.
S.V. Zaikov, M.A. Lykova, N.A. Hritsova, L.V. Veselovsky   +3 more
doaj   +1 more source

The Value of Enzyme-linked Immunospot Assay in Identifying Causative Agents in Patients with Hypersensitivity Reactions to Antitubercular Agents [PDF]

Zhongguo quanke yixue
Background Hypersensitivity reactions of antitubercular agents are very common in clinical practice. Drug provocation test is the only effective method to find out the causative agents, but it may cause re-sensitization or even shock, which can be life ...
WU Yuqing, LIU Zhou, LIAO Yongmei
doaj   +1 more source

Expert Perspectives: Defining and Managing Progressive Pulmonary Fibrosis in Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Systemic sclerosis–associated interstitial lung disease (SSc‐ILD) is one of the leading causes of morbidity and mortality in SSc, affecting up to three‐quarters of patients. The disease course is highly heterogeneous, ranging from indolent, nonprogressive forms to rapidly progressive pulmonary fibrosis (PPF).
Devis Benfaremo, Dinesh Khanna, Corrado Campochiaro, Vincent Cottin, Fabrizio Luppi, Marco Matucci‐Cerinic, Gianluca Moroncini, Yannick Allanore   +7 more
wiley   +1 more source

Multiple drug hypersensitivity: normal Treg cell function but enhanced in vivo activation of drug-specific T cells

, 2011
Up to 10% of patients with severe immune-mediated drug hypersensitivity reactions have tendencies to develop multiple drug hypersensitivities (MDH). The reason why certain individuals develop MDH and the underlying pathomechanism are unclear.
Lerch, M, Groux-Keller, M, Park, B K, Naisbitt, D J, Wendland, T, Hausmann, O V, D. J. Naisbitt, T. Kawabata, Daubner, B, B. K. Park, M. Lerch, Pichler, W J, B. Daubner, W. J. Pichler, M. Groux-Keller, O. V. Hausmann, Kawabata, T, T. Wendland   +17 more
core   +1 more source