Results 91 to 100 of about 1,960,750 (298)

Successful Desensitization of a Patient with Rituximab Hypersensitivity

Case Reports in Immunology, 2015
Rituximab is a monoclonal antibody which targets CD20 in B cells that is used for the treatment of CD20 positive oncologic and hematologic malignancies. Rituximab causes hypersensitivity reactions during infusions.
Pinar Ataca, Erden Atilla, Resat Kendir, Sevim Bavbek, Muhit Ozcan   +4 more
doaj   +1 more source

Targeting CXCR2 in Nociceptive Sensory Neurons Offers Novel Therapeutic Potentials for Postoperative Pain

Advanced Science, EarlyView.
Tissue incision induces CXCL5 release, which activates neuronal CXCR2 on incision‐innervating sensory neurons. Neuronal CXCR2 couples with TRPA1 to drive mechanical pain and engages p38 MAPK signaling to upregulate TRPV1 and promote heat pain. Targeted Cxcr2 knockdown relieves incisional pain while preserving CXCR2‐dependent neutrophil responses ...
Yushuang Pan, Peiyi Li, Yufeng Chen, Zishan Dong, Yuanyuan Li, Boyu Liu, Yan Tai, Chuan Wang, Jianqiao Fang, Chengyu Yin, Boyi Liu   +10 more
wiley   +1 more source

Reações do tipo alérgico a medicamentos utilizados no consultório odontológico: uma revisão de literatura [PDF]

, 2012
TCC (graduação) - Universidade Federal de Santa Catarina. Centro de Ciências da Saúde. Odontologia.Grande parte dos pacientes que são atendidos nos consultórios odontológicos necessitam de terapia medicamentosa durante o seu tratamento.
Menegotto Filho, Guilherme Antonio
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Regulating Cells Fate and Function to Facilitate Bone Regeneration via Designing Programmable Bio‐Interactive Materials

Advanced Science, EarlyView.
This article aims to elucidate the biological mechanisms of bone repair and the evolution of material design, highlighting key cellular and molecular processes. It further proposes strategies and prospects for programmable bio‐interactive materials, which enable precisely guided bone tissue regeneration by dynamically regulating cell behavior and the ...
Qingrui Fan, Fuming Cao, Junqiang Mao, Pengbin Yin, Licheng Zhang, Jianjun Wang, Peifu Tang   +6 more
wiley   +1 more source

Immunosuppressants in dermatology on vaccine immunogenicity: a prospective cohort study of pemphigus patients in the pandemic

Frontiers in Immunology
IntroductionBoth cellular and humoral responses are important for vaccine protection, but recommendations on immunosuppressants in dermatology are largely based on pre-pandemic experiences.
Kun-Lin Lu, Kun-Lin Lu, Kun-Lin Lu, Kun-Lin Lu, Kun-Lin Lu, Hua-En Lee, Hua-En Lee, Chun-Bing Chen, Chun-Bing Chen, Chun-Bing Chen, Chun-Bing Chen, Chun-Bing Chen, Chun-Bing Chen, Chun-Bing Chen, Chun-Bing Chen, Chun-Bing Chen, Rosaline Chung-Yee Hui, Rosaline Chung-Yee Hui, Ya-Ching Chang, Ya-Ching Chang, Chun-Wei Lu, Chun-Wei Lu, Chun-Wei Lu, Chun-Wei Lu, Chun-Wei Lu, Chuang-Wei Wang, Chuang-Wei Wang, Chuang-Wei Wang, Chuang-Wei Wang, Wen-Hung Chung, Wen-Hung Chung, Wen-Hung Chung, Wen-Hung Chung, Wen-Hung Chung, Wen-Hung Chung, Wen-Hung Chung, Wen-Hung Chung, Wen-Hung Chung, Wen-Hung Chung, Wen-Hung Chung   +39 more
doaj   +1 more source

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source

Photoactivated Platinum Complexes: Targeting Membrane Proteins and Organelles for Precision Cancer Therapy

Angewandte Chemie, EarlyView.
This review highlights an emerging anticancer approach integrating platinum agents into photodynamic therapy (PDT) and photoactivated chemotherapy (PACT) systems, further augmented by cancer cell membrane‐ and organelle‐targeting. By directing photoactivated platinum complexes from nontargeted distribution to cancer cells or defined subcellular sites ...
Shu Chen, Qiyuan Zhou, Jiaqian Xu, Guangyu Zhu   +3 more
wiley   +2 more sources

Desensitization Protocols for Hypersensitivity Induced by Cytotoxic Drugs;  Platinum Salts and Taxanes

Pakistan Armed Forces Medical Journal
With the expanding use of Platins and Taxanes for cancer patients, a highly concerning threat is observed in the form of Hypersensitivity reactions. To reduce hypersensitivity reactions, different desensitization protocols are formed.
Maha Zahid, Husnain Hamid, Numra Tahir, Aqsa Amjad, Irfan Bashir, Muhammad Jamshaid   +5 more
doaj   +1 more source

Vancomycin-Induced Stevens-Johnson Syndrome in a Boy Under 2 Years Old: An Early Diagnosis by Granulysin Rapid Test

Frontiers in Pediatrics, 2018
Stevens-Johnson syndrome (SJS) is a life-threatening disease, which is mainly ascribed to drugs, such as sulfonamides and psychoepileptics. In this article, we present a pediatric case of vancomycin-induced SJS and an alternative diagnostic algorithm ...
You-Cheng Lin, You-Cheng Lin, Ji-Nan Sheu, Ji-Nan Sheu, Wen-Hung Chung, Wen-Hung Chung, Ren-You Pan, Chu-Ju Hung, Jen-Jung Cheng, Yu-Ping Hsiao, Yu-Ping Hsiao   +10 more
doaj   +1 more source

Genetic screening to prevent abacavir hypersensitivity reaction: Are we there yet? [PDF]

, 2006
Editorial ...
Phillips, E.J.
core