Results 81 to 90 of about 2,423,182 (300)

Effect of drug desensitization on drug hypersensitivity-related quality of life

, 2021
PubMed: 33186768TO THE EDITOR: Trying to avoid exposure to drugs, anxiety about recurrence of an allergic reaction, and concerns about using drugs may adversely affect quality of life (QOL) in patients with drug hypersensitivity.
Kepil Özdemir, Seçil, Işık, Sacide Rana, Dursun, Adile Berna, Öztürk A.B., Ozdemir, Secil Kpeil, DOĞANAY, BEYZA, Isik, Sacide Rana, Dursun A.B., Göksel Ö., Erdogan, Beyza Doganay, Kepil Özdemir S., Görgülü B., Doğanay Erdoğan B., Bavbek S., Görgülü, Begüm, Doğanay Erdoğan, Beyza, Bavbek, Sevim, Göksel, Özlem, Öztürk, Ayşe Bilge, Özlem Göksel, Adile Berna Dursun, Ayşe Bilge Öztürk, Begüm Görgülü, Beyza Doğanay Erdoğan, Seçil Kepil Özdemir, Sacide Rana Işık, Sevim Bavbek   +26 more
core   +1 more source

Metabolic‐Redox Remodeling of Inflammatory Synovium by Mannose‐Modified Selenium Nanoparticles for Osteoarthritis Therapy

Advanced Science, EarlyView.
Elevated GLUT1‐driven glycolysis and disrupted selenoprotein‐dependent redox homeostasis drive osteoarthritic progression. Intra‐articular mannose‐modified selenium nanoparticles (M‐SeNPs) selectively target hypermetabolic synovial cells to reprogram aberrant glycolysis and restore endogenous antioxidant defenses.
Yu‐Qing Zou, Chen‐Hao Xu, Bo‐Wei Li, Leung Chan, Yi‐Di Xu, Han‐Bo Su, Rui Peng, Fang‐Ji Luo, Ya‐Chen Peng, Zhen‐Yan Li, Vincent Kam Wai Wong, Xiao‐Fei Zheng, Xing Ma, Zhen‐Gang Zha, Tianfeng Chen, Huan‐Tian Zhang   +15 more
wiley   +1 more source

Successful Desensitization of a Patient with Rituximab Hypersensitivity

Case Reports in Immunology, 2015
Rituximab is a monoclonal antibody which targets CD20 in B cells that is used for the treatment of CD20 positive oncologic and hematologic malignancies. Rituximab causes hypersensitivity reactions during infusions.
Pinar Ataca, Erden Atilla, Resat Kendir, Sevim Bavbek, Muhit Ozcan   +4 more
doaj   +1 more source

Pharmacogenetics of hypersensitivity drug reactions

, 2017
Adverse drug reactions are a significant cause of morbidity and mortality and represent a major burden on the healthcare system. Some of those reactions are immunologically mediated (hypersensitivity reactions) and can be clinically subdivided into two ...
Becquemont, Laurent, Negrini, Simone
core   +1 more source

Drug Hypersensitivity: How Drugs Stimulate T Cells via Pharmacological Interaction with Immune Receptors. [PDF]

, 2015
Small chemicals like drugs tend to bind to proteins via noncovalent bonds, e.g. hydrogen bonds, salt bridges or electrostatic interactions. Some chemicals interact with other molecules than the actual target ligand, representing so-called 'off-target ...
Yun, James Jin Sup, Watkins, Stephen, Yerly, Daniel, Pichler, Werner Joseph, Adam, Jacqueline, Wuillemin, Natascha Andrea   +5 more
core   +2 more sources

A Dual‐Functional Nanoplatform Targeting the dsDNA–cGAS Axis to Mitigate Disc Degeneration and Aberrant Innervation

Advanced Science, EarlyView.
RU@PEI‐ZIF integrates dsDNA scavenging with local cGAS inhibition to suppress the dsDNA–cGAS–STING/Netrin‐1 axis in intervertebral disc degeneration. By attenuating nucleus pulposus cell senescence, inflammatory and matrix‐catabolic responses, and pathological sensory innervation, this dual‐functional nanoplatform preserves disc integrity and reduces ...
Zhaojun He, Tianyu Chen, Zezheng Liu, Xinlin Huang, Ruitangbin Jiang, Yihao Liu, Baojing Xu, Yuxiang Li, Kangning Zhao, Huibo Yan, Lei Zhou, Can Liu, Qingchu Li   +12 more
wiley   +1 more source

Immunosuppressants in dermatology on vaccine immunogenicity: a prospective cohort study of pemphigus patients in the pandemic

Frontiers in Immunology
IntroductionBoth cellular and humoral responses are important for vaccine protection, but recommendations on immunosuppressants in dermatology are largely based on pre-pandemic experiences.
Kun-Lin Lu, Kun-Lin Lu, Kun-Lin Lu, Kun-Lin Lu, Kun-Lin Lu, Hua-En Lee, Hua-En Lee, Chun-Bing Chen, Chun-Bing Chen, Chun-Bing Chen, Chun-Bing Chen, Chun-Bing Chen, Chun-Bing Chen, Chun-Bing Chen, Chun-Bing Chen, Chun-Bing Chen, Rosaline Chung-Yee Hui, Rosaline Chung-Yee Hui, Ya-Ching Chang, Ya-Ching Chang, Chun-Wei Lu, Chun-Wei Lu, Chun-Wei Lu, Chun-Wei Lu, Chun-Wei Lu, Chuang-Wei Wang, Chuang-Wei Wang, Chuang-Wei Wang, Chuang-Wei Wang, Wen-Hung Chung, Wen-Hung Chung, Wen-Hung Chung, Wen-Hung Chung, Wen-Hung Chung, Wen-Hung Chung, Wen-Hung Chung, Wen-Hung Chung, Wen-Hung Chung, Wen-Hung Chung, Wen-Hung Chung   +39 more
doaj   +1 more source

Drug Induced Hypersensitivity and the HLA Complex

Pharmaceuticals, 2010
Drug-induced hypersensitivity reactions are of major concern and present a burden for national healthcare systems due to their often severe nature, high rate of hospital admissions and high mortality. They manifest with a wide range of symptoms and signs,
Munir Pirmohamed, Ana Alfirevic
doaj   +1 more source

Proteomics in drug hypersensitivity [PDF]

, 2016
21 p.-4 fig.-1 tab.Drug hypersensitivity reactions result from the activation of the immune system by drugs or their metabolites. The clinical presentations of drug hypersensitivity can range from relatively mild local manifestations to severe systemic ...
Pérez-Sala, Dolores, González-Morena, Juan M., Sánchez-Gómez, Francisco J., Montañez, M. I., Aldini, Giancarlo   +4 more
core   +1 more source

Pyruvate Kinase M2‐Mediated H3K9 Lactylation and XBP1 Signaling Positive Feedback Loop Facilitates CD4+ T Cell Spinal Recruitment and Central Sensitization in Rheumatoid Arthritis

Advanced Science, EarlyView.
In collagen‐induced arthritis (CIA) mice, increased CD4+ T cell accumulation in the spinal dorsal horn induces pain hypersensitivity. Mechanistically, PKM2‐mediated H3K9 lactylation and XBP1 signaling positive feedback loop facilitates CD4+ T cell spinal migration and induces central sensitization‐like behaviors in CIA mice.
Yuepeng Jiang, Xiaoxuan Zhao, Xiao Ma, Mengjia Zheng, Junjun Wen, Yujie Li, Yue Wu, Yun Zhang, Jie Yu, Charles R. Ashby Jr, Chengping Wen   +10 more
wiley   +1 more source