Results 81 to 90 of about 1,960,750 (298)

Analysis of the Costs Associated With the Elective Evaluation of Patients Labelled as Allergic to Beta-Lactams or Nonsteroidal Antiinflamatory Agents

Frontiers in Pharmacology, 2020
Introduction: Being labelled as allergic to different drugs results in patients receiving other treatments, which are more toxic, less effective and more expensive.
Miriam Sobrino-García, Esther M. Moreno, Esther M. Moreno, Esther M. Moreno, Esther M. Moreno, Francisco J. Muñoz-Bellido, Francisco J. Muñoz-Bellido, Francisco J. Muñoz-Bellido, Maria T. Gracia-Bara, Maria T. Gracia-Bara, Elena Laffond, Elena Laffond, Elena Laffond, Inmaculada Doña, Inmaculada Doña, Inmaculada Doña, Cristina Martín, Cristina Martín, Eva M. Macías, Eva M. Macías, Eva M. Macías, Sonia de Arriba, Sonia de Arriba, Sonia de Arriba, Valle Campanón, Alicia Gallardo, Ignacio Dávila, Ignacio Dávila, Ignacio Dávila, Ignacio Dávila   +29 more
doaj   +1 more source

A simple screening approach to reduce B*5701-associated abacavir hypersensitivity on the basis of sequence variation in HIV reverse transcriptase [PDF]

, 2007
Background. Abacavir hypersensitivity is strongly associated with the human leukocyte antigen (HLA)–B*5701 allele; however, the cost of routine high-resolution HLA typing before initiation of therapy remains prohibitive.
Chui, C.K.S., Brumme, Z.L., Brumme, C.J., Yip, B., Montaner, J.S.G., Phillips, E.J., Harrigan, P.R.   +6 more
core  

Immunological mechanisms of drug hypersensitivity [PDF]

, 2016
Drug hypersensitivity reactions (DHRs) are adverse drug reactions that may be divided into several categories; namely pharmacologic intolerance, idiosyncratic reactions, pseudo-allergic reactions and allergic reactions.
Meng, X, Waddington, J, Ariza, A, Park, K, Naisbitt, D   +4 more
core   +1 more source

O‐GlcNAcylation Regulation of SNAP29‐Dependent Autophagy Activation Dictates Chemoresistance in Gastric Cancer

Advanced Science, EarlyView.
Model illustrating the proposed mechanism by which chemotherapy‐induced downregulation of OGT disrupts SNAP29 O‐GlcNAcylation, promoting STX17‐SNAP29‐VAMP8 SNARE complex assembly and protective autophagy, leading to chemoresistance, which in turn establishes a feedforward loop to perpetuate drug tolerance.
Liang Tang, Shaoji Zhao, Ziling Shao, Tao Luo, Baifu Peng, Yifan Liu, Jinning Ye, Jianjun Peng, Kaiyu Sun, Jianbo Xu   +9 more
wiley   +1 more source

Systematic Multi‐Level Analyses Decode the Arthritis‐Neurodegeneration Axis With In Vivo Validation

Advanced Science, EarlyView.
Arthritis and neurodegeneration are usually studied as separate disorders, but this study connects them through population evidence, genetic inference, transcriptomic mapping, and mouse models. It highlights RNF40 as a context‐dependent joint‐brain candidate, induced in inflammatory joints yet functionally linked to dopamine‐neuron vulnerability ...
Jinwen Wang, Wenhui Xie, Lei Yang, Zhengrong Wang, Yi Huang, Peng Huang, Yuan Liu, Jun Hu   +7 more
wiley   +1 more source

Drug Hypersensitivity: How Drugs Stimulate T Cells via Pharmacological Interaction with Immune Receptors. [PDF]

, 2015
Small chemicals like drugs tend to bind to proteins via noncovalent bonds, e.g. hydrogen bonds, salt bridges or electrostatic interactions. Some chemicals interact with other molecules than the actual target ligand, representing so-called 'off-target ...
Yun, James Jin Sup, Watkins, Stephen, Yerly, Daniel, Pichler, Werner Joseph, Adam, Jacqueline, Wuillemin, Natascha Andrea   +5 more
core   +2 more sources

Loss of SHP1 in Spinal Astrocytes Triggers T‐Lymphocyte Infiltration and Nociceptive Hypersensitivity

Advanced Science, EarlyView.
Astrocyte‐specific SHP1 deletion disrupts astrocyte–vascular interactions and compromises BBB integrity while enhancing STAT1‐dependent CXCL10 expression. These changes synergistically promote peripheral CD4+ and CD8+ T‐cell infiltration into the SDH. The infiltrating T cells secrete IFN‐γ, which in turn activates microglia.
Lan‐Xing Yi, Lin Yang, Kang‐Li Wang, Hui‐Zhu Liu, Rui‐Ying Chen, Min Su, Xiao Xiao, Yu‐Qiu Zhang   +7 more
wiley   +1 more source

Drug Induced Hypersensitivity and the HLA Complex

Pharmaceuticals, 2010
Drug-induced hypersensitivity reactions are of major concern and present a burden for national healthcare systems due to their often severe nature, high rate of hospital admissions and high mortality. They manifest with a wide range of symptoms and signs,
Munir Pirmohamed, Ana Alfirevic
doaj   +1 more source

Immune pathomechanism of drug hypersensitivity reactions

, 2011
Drug hypersensitivity research has progressed enormously in recent years, and a greater understanding of mechanisms has contributed to improved drug safety.
Dean J. Naisbitt, Pichler, Werner J, Naisbitt, Dean J, Werner J. Pichler, B. Kevin Park, Park, B Kevin   +5 more
core   +1 more source

VlPAG/DRN Microglia Drive Neuropathic Pain‐Induced Depression via a Defined Neuroimmune Axis

Advanced Science, EarlyView.
Peripheral nerve injury (SNI) induces neuropathic pain, activates midbrain microglia, and triggers an NLRP3–IL‐1β–dependent inflammatory cascade. IL‐1β signals through IL‐1R1 on vlPAG/DRN VGLUT2+ neurons (vlPAG/DRNGlu), inducing hyperexcitability and driving the vlPAG/DRNGlu→BNSTGABA circuit to produce the affective component of neuropathic pain ...
Jing Yang, Bing‐Jie Tang, Jia‐Yi Li, Shu‐Lan Xie, Shumin Duan, Junping Chen, Shengmei Zhu, Zhen‐Zhong Xu   +7 more
wiley   +1 more source