Results 161 to 170 of about 2,423,182 (300)

Clinical Significance of Acute Kidney Injury in Idiosyncratic Drug‐Induced Liver Injury: A Multicentric Propensity Scores Matched Study

Clinical Pharmacology &Therapeutics, EarlyView.
Clinical significance of acute kidney injury in idiosyncratic drug‐induced liver injury: a multicentric propensity scores matched study. Evidence about the role of acute kidney injury (AKI) in idiosyncratic drug‐induced liver injury (DILI) is still scarce.
José María Pinazo‐Bandera, Hao Niu, Juan Pedro Toro‐Ortiz, Inmaculada Medina‐Caliz, Judith Sanabria‐Cabrera, Aída Ortega‐Alonso, Mercedes Robles‐Díaz, Daniel Enrique Di Zeo‐Sanchez, Nelia Hernández, Fernando Bessone, Vinicius Nunes, Raymundo Paraná, M. Isabel Lucena, Raul J. Andrade, Ismael Alvarez‐Alvarez, Miren García‐Cortés   +15 more
wiley   +1 more source

Clinical utility of lymphocyte transformation testing for antituberculosis drug hypersensitivity. [PDF]

JAAD Int
Pornsuthirat P, Tansit T, Ud-Naen S, Tuchinda P, Angkasekwinai N, Chierakul N, Rerkpattanapipat T, Klaewsongkram J, Srinoulprasert Y.   +8 more
europepmc   +1 more source

Enhancing Evidence Generation by Linking Randomized Clinical Trials to Real‐World Data: The INVESTED‐Medicare Linkage Study

Clinical Pharmacology &Therapeutics, EarlyView.
Real‐world evidence (RWE) derived from real‐world data (RWD) can complement randomized controlled trials (RCTs), yet the validity of RWD relative to RCT data remains insufficiently characterized. We obtained post hoc consent and linked individual participant data from the US‐based INVESTED trial (2016–2019) with Medicare fee‐for‐service claims (2012 ...
Hanseul Cho, HoJin Shin, Mehdi Najafzadeh, Brian Claggett, Janinne Ortega‐Montiel, Jun Liu, Julie M. Paik, Narlina F. Lalani, Marie C. Bradley, John Concato, Scott D. Solomon, Orly Vardeny, Elisabetta Patorno   +12 more
wiley   +1 more source

Prediction of drug hypersensitivity by comprehensive modeling of HLA-peptidomes. [PDF]

Brief Bioinform
Zhong Y, Lauschke VM, Wang Y, Zhou Y.
europepmc   +1 more source

Phase I Evaluation of Siltartoxatug, a First‐in‐Class Anti‐Tetanus Monoclonal Antibody: Safety, Pharmacokinetics and Pharmacodynamics in Healthy Australian and Chinese Populations

Clinical Pharmacology &Therapeutics, EarlyView.
Siltartoxatug, a first‐in‐class monoclonal antibody targeting tetanus toxin for post‐exposure prophylaxis, was evaluated in two phase I trials in Australian and Chinese healthy adults. In these randomized, double‐blind, placebo‐controlled, dose‐escalation studies, participants received a single intramuscular injection of siltartoxatug (10–250 μg/kg) or
Xinyu Liu, Zhigang Liu, Xiaohu Kuang, Yueming Wang, Xiaoyi Liu, Jiyuan Ding, Xia Zhou, Xin Zhou, Qianyu Liang, Meizhuo Zhang, Hao Zhao, Qingqing Tan, Weihong Zheng, Huaxin Liao, Charlotte Lemech, Wanmei Wang   +15 more
wiley   +1 more source

Impact of Food and Beverage on Enlicitide Pharmacokinetics and LDL‐C Lowering

Clinical Pharmacology &Therapeutics, EarlyView.
Enlicitide decanoate is a macrocyclic peptide first‐in‐class oral PCSK9 inhibitor that lowers LDL‐C, with maximal efficacy achieved when administered on an empty stomach. This work characterizes the effects of food, pre‐dose fasting duration (2–8 hours), water volume, common beverages (black coffee and plain tea), and other real‐world scenarios on ...
Douglas G. Johns, Maja Skataric, Susan Zhou, Ferdous Gheyas, Ednan Bajwa, Puja Banka, Filippos Kesisoglou, Allen Hunt, David Bruce, Corey Anderson, Helen Manthos, Jonathan Pollock, Paul J. Donabella, Campbell Thompson, Daniel Freire, Kiet Giang, Frank Pietrantonio, Dennis Wolford, Piyali Basak, Maxwell Pistilli, Bhavna Kantesaria, Prajakti Kothare, Islam R. Younis   +22 more
wiley   +1 more source

Anxiety Before and After Drug Provocation Testing in Drug Hypersensitivity: Who Remains Anxious Despite a Reassuring Test? [PDF]

J Asthma Allergy
Kural RF, Tunakan Dalgıç C, İnan S, Özışık M, Akten S, Okan K, Gumusburun R, Mete Gökmen EN, Sin AZ.   +8 more
europepmc   +1 more source

Confirmed Multiple Drug Hypersensitivity Syndrome is Uncommon, and its Culprit Drug Spectrum Reflects Patterns of Drug Exposure

Clinical Pharmacology &Therapeutics, EarlyView.
Multiple drug hypersensitivity syndrome (MDHS) is defined as confirmed hypersensitivity to two or more chemically and pharmacologically unrelated drug entities. Few studies have characterized MDHS with systematic diagnostic confirmation. We aimed to determine the frequency, culprit drug patterns, and diagnostic findings of confirmed MDHS.
Da Woon Sim, Ji Eun Yu, Young‐Il Koh
wiley   +1 more source

Validation of the English Drug Hypersensitivity Quality of Life Questionnaire (DrHy-Q). [PDF]

Allergy
Ozyigit LP, Romero P, Baygul A, Madrigal-Burgaleta R, Savic L, Danaci S, Walshaw E, Parkes A, Baiardini I, Romano A, Bradding P, Khan N, Vazquez-Ortiz M.   +12 more
europepmc   +1 more source

The β integrin modulates serotonin sensitivity via NPxY motifs to regulate egg laying and mechanosensation behaviors in Caenorhabditis elegans

Developmental Dynamics, EarlyView.
Abstract Background Integrin is an αβ heterodimeric receptor to the extracellular matrix; its binding to the matrix recruits focal adhesions to two NPxY motifs, the tyrosine phosphorylation sites in the cytoplasmic domain. Studies found that replacing tyrosines (Y) with phenylalanines (F) in the motif of β1 integrin displayed little developmental or ...
Josh Haram Bumm, Daniel Dogeon Lee, Zhongqiang Qiu, Angela Haeun Choi, Meghana Kolluri, Michael J. Olsen, Lianzijun Wang, Myeongwoo Lee   +7 more
wiley   +1 more source