Results 201 to 210 of about 138,421 (254)

Migraine Features in Patients With Sudden Sensorineural Hearing Loss

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective To investigate the prevalence of migraine features among patients with sudden sensorineural hearing loss (SSNHL) and evaluate potential clinical associations. Study Design Retrospective survey‐based study. Setting Single institution tertiary care center. Methods 168 adult patients with SSNHL were recruited.
Yalda Yazdani, Ella J. Lee, Amanda Francis, Saharnaz Nedjat, Mehdi Abouzari, Hamid R. Djalilian   +5 more
wiley   +1 more source

Design and Synthesis of Polyamine‐Proteolysis Targeting Chimera Conjugates for Histone Deacetylase (HDAC) Degradation with Enhanced Cellular Uptake

ChemistryOpen, EarlyView.
In this article, proteolysis targeting chimeras (PROTACs) bearing a polyamine linker capable of crossing cancer cell membranes via the polyamine transport system are synthesized and evaluated. The results provide valuable insights for the design of PROTACs with enhanced cellular uptake efficiency.
Yanran Liu, Wentian Chen, Yanwei Shang, Chaonan Tang, Xianming Zeng, Jun Li, Wenting Du   +6 more
wiley   +1 more source

Investigation of the Mechanism of Cinnamaldehyde in Irritable Bowel Syndrome Based via Network Pharmacology, Molecular Docking, and Animal Experiments

Pediatric Discovery, EarlyView.
Through network pharmacology and molecular docking, it has been discovered that CA can target MAOB, among other proteins, to exert a therapeutic effect in IBS. In vivo, CA lowered visceral hypersensitivity, anxiety and depression‐like behaviors, and fecal water content, highlighting its therapeutic potential for IBS via anti‐inflammatory pathways ...
Qingyang Yu, Boqing Xu, Chunfang Dai, Yayan Pang, Zhifang Dong   +4 more
wiley   +1 more source

Drug‐induced hypersensitivity syndrome followed by exacerbation of Crohn's disease

Pediatric Investigation, EarlyView.
Mei Kamidani, Ryo Tanaka, Hiroshi Oue, Risa Fukuda, Rena Hashimoto, Ichiro Takeuchi, Takako Yoshioka, Naoya Tonegawa, Akira Ishiguro, Katsuhiro Arai, Kazue Yoshida   +10 more
wiley   +1 more source

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Drug Hypersensitivity Reactions

Medical Clinics of North America, 2020
Drug hypersensitivity reactions (DHRs) may be classified based on timing (immediate vs delayed), mechanisms, and pattern of clinical manifestations. Management may include selection of alternative, non-cross reactive agents, drug allergy testing, graded challenge and/or desensitization.
Mark S, Dykewicz, Jason K, Lam
openaire   +2 more sources

Hypersensitivity drug reactions

Current Opinion in Allergy & Clinical Immunology, 2014
In this new issue of Current Opinion in Allergy and Clinical Immunology, five major areas of research in the field of hypersensitivity reactions to drugs in the past year are reviewed. The manuscript of Blanca-Lopez et al.[1] is devoted to hypersensitivity reactions to NSAIDs.
Bernard Y, Thong, Miguel, Blanca
openaire   +2 more sources

Drug Hypersensitivity Reactions

Emergency Medicine Clinics of North America, 2022
Drug hypersensitivity reactions are a diverse group of reactions mediated by the immune system after exposure to a drug. The Gell and Coombs classification divides immunologic DHRs into 4 major pathophysiologic categories based on immunologic mechanism. Anaphylaxis is a Type I hypersensitivity reaction that requires immediate recognition and treatment.
openaire   +3 more sources

Drug Hypersensitivity

Immunology and Allergy Clinics of North America, 2014
Before the arrival of modern pharmacotherapy, drug hypersensitivity reactions were virtually unknown. Toxicity from the many plant-, animal- and inorganic material-derived remedies must have been much more common. One famous example is the intoxications from mercury, which has been used in many ailments, but particularly for the treatment of syphilis ...
openaire   +3 more sources

Immediate Drug Hypersensitivity

Current Allergy and Asthma Reports, 2016
Drug allergy affects a large percentage of the general population. A listed drug allergy can also have broad implications for many aspects of patient care. Here, we will review recent advances in the arena of drug allergies with a focus on antibiotics, monoclonals, NSAIDs, and chemotherapeutics.
Paige G, Wickner, David, Hong
openaire   +2 more sources

Pediatric Drug Hypersensitivity

Current Allergy and Asthma Reports, 2019
Pediatric drug hypersensitivity is a rapidly evolving field. The purpose of this paper is to review the current state of pediatric drug hypersensitivity and highlight new developments in diagnosis and management.This paper will discuss the safety and use of risk stratification to proceed directly to oral challenge without prior skin testing for β ...
Christine R F, Rukasin, Allison E, Norton, Ana Dioun, Broyles   +2 more
openaire   +2 more sources