Results 191 to 200 of about 220,353 (256)

A Non‐Antigenic Randomized Polyethylene Glycol/Poly(2‐Phenyl‐2‐Oxazine)‐Based Drug Delivery Platform

Macromolecular Rapid Communications, EarlyView.
Randomized PEG (rPEG), a conceptually new PEG alternative, is combined with poly(2‐phenyl‐2‐oxazine) (PPheOzi) to establish an rPEG‐b‐PPheOzi‐b‐rPEG micellar drug delivery platform. The PPheOzi block enables high drug loadings, while competitive ELISA reveals a drastic reduction in anti‐PEG antibody affinity of rPEG in comparison to PEG.
Julian Schmidt, Anna‐Lena Ziegler, Florian T. Kaps, Laura J. Rosenberger, Matthias Bros, Holger Frey, Robert Luxenhofer   +6 more
wiley   +1 more source

Circadian Immunity and Vascular Inflammation in Cardiovascular Disease Chronotherapy Windows: Time for a Re‐Assessment

Med Research, EarlyView.
ABSTRACT Circadian rhythms orchestrate cardiovascular physiology by regulating immune and inflammatory pathways. Disruption of these rhythms profoundly alters vascular homeostasis, thereby promoting the onset and progression of cardiovascular diseases (CVD).
Tian Zhang, Ge Zhang, Tian‐Ding Liu, Tianshu Gu, Fengyi Yu, Pengyuan Xu, Wunan Mi, Xuanjiang Zhao, Qian Guo, Honglin Zheng, Taiqi Zhao, Qiang Li, Di Lu, Mingxuan Duan, Chaoyang Yu, Ruhao Wu, Shiqian Zhang, Haonan Zhang, Zeyu Wang, Youyang Zheng, Yan Xiao, Zenglei Zhang, Ge Zhang   +22 more
wiley   +1 more source

Antituberculosis-Drugs Induced DRESS: A Multidrug Hypersensitivity or Drug Hypersensitivity Relapse? A Case Report. [PDF]

Hosp Pharm
Mansour K, Chadli Z, Ben Fadhel N, Ben Fredj N, Ben Romdhane H, Chaabane A, Toumi A, Aouam K.   +7 more
europepmc   +1 more source

Portal vein thrombosis and liver transplantation (Letter) [PDF]

, 1993
Odocha, O, Starzl, TE, Stieber, AC, Tzakis, AG, Van Thiel, DH   +4 more
core  

Diabetic Peripheral Neuropathy: Molecular Staging, Risk Factors, Therapeutics, and Emerging Trends

Med Research, EarlyView.
The heterogeneous landscape of DPN can be unified through a tripartite pathogenic model encompassing progressive stages of metabolic dysregulation, chronic inflammation, and overt neuronal damage. Within this framework, six clinical subtypes were identified, namely, hyperglycemia‐driven, dyslipidemia‐driven, inflammation‐driven, dysvascularity‐driven ...
Xiaofeng Dai, Mingze Tang
wiley   +1 more source

Toxic epidermal necrolysis-like linear IgA bullous dermatosis as a manifestation of multiple drug hypersensitivity in the setting of drug reaction with eosinophilia and systemic symptoms. [PDF]

JAAD Case Rep
Stratman S, Zhou L, Kim RH, Phelps RG, Glickman J, Mikhaylov D, Wu J, El-Kashlan N, Rivera-Oyola R, Adalsteinsson JA, Levoska MA, Gulati N.   +11 more
europepmc   +1 more source

What Role Does the Central Nervous System Play in Refractory LUTS, and What Are the Therapeutic Implications? ICI‐RS 2025

Neurourology and Urodynamics, EarlyView.
ABSTRACT Aims While many patients with lower urinary tract symptoms (LUTS) improve by treating peripheral causes, a substantial proportion continue to experience symptoms despite apparently successful interventions. Central nervous system (CNS) mechanisms could potentially contribute to persisting symptoms after the initial peripheral cause has been ...
Mathijs M. de Rijk, Michel Wyndaele, Ana Charrua, Christopher Fry, Paul Abrams, Gommert A. van Koeveringe, Anthony J. Kanai, Marcus J. Drake   +7 more
wiley   +1 more source

Investigation of the Mechanism of Cinnamaldehyde in Irritable Bowel Syndrome Based via Network Pharmacology, Molecular Docking, and Animal Experiments

Pediatric Discovery, EarlyView.
Through network pharmacology and molecular docking, it has been discovered that CA can target MAOB, among other proteins, to exert a therapeutic effect in IBS. In vivo, CA lowered visceral hypersensitivity, anxiety and depression‐like behaviors, and fecal water content, highlighting its therapeutic potential for IBS via anti‐inflammatory pathways ...
Qingyang Yu, Boqing Xu, Chunfang Dai, Yayan Pang, Zhifang Dong   +4 more
wiley   +1 more source

Deficits in burrowing behaviors are associated with mouse models of neuropathic but not inflammatory pain or migraine [PDF]

, 2018
Cao, Yu-Qing, Cloud, Megan E, Mohapatra, Durga P, Shepherd, Andrew J   +3 more
core   +1 more source

Nanoparticle polymeric micellar paclitaxel compared with paclitaxel for advanced esophageal squamous cell carcinoma

Precision Medical Sciences, EarlyView.
The nanoparticle polymeric micellar paclitaxel plus nedaplatin regimen demonstrates superior efficacy and tolerable toxicities compared to the paclitaxel–nedaplatin combination as a first‐line treatment for advanced esophageal squamous cell carcinoma.
Yu‐Qing Cao, Meng Song, Bing‐jie Xue, Fei‐Yu Wang, Xiang‐Ming Huang, Jie Cao, Ai‐Guo Cao, Xin‐En Huang   +7 more
wiley   +1 more source